ID A0A1W2CKY8_9PSEU Unreviewed; 6022 AA.
AC A0A1W2CKY8;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Non-ribosomal peptide synthase domain TIGR01720/amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SMC85686.1};
GN ORFNames=SAMN05660733_02148 {ECO:0000313|EMBL:SMC85686.1};
OS Lentzea albidocapillata.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Lentzea.
OX NCBI_TaxID=40571 {ECO:0000313|EMBL:SMC85686.1, ECO:0000313|Proteomes:UP000192840};
RN [1] {ECO:0000313|Proteomes:UP000192840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44073 {ECO:0000313|Proteomes:UP000192840};
RA Varghese N., Submissions S.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FWYC01000005; SMC85686.1; -; Genomic_DNA.
DR RefSeq; WP_030475093.1; NZ_JOEA01000003.1.
DR STRING; 40571.SAMN05660733_02148; -.
DR eggNOG; COG1020; Bacteria.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000192840; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 3.
DR CDD; cd17652; A_NRPS_CmdD_like; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 10.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 4.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 8.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF13193; AMP-binding_C; 5.
DR Pfam; PF00668; Condensation; 8.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 16.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 934..1008
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2246..2321
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3210..3284
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4543..4618
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5536..5610
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 6022 AA; 656845 MW; 41F16794266CD512 CRC64;
MTTSKQDRAS ALPAHLRDQL RKRLAGAVPA TPVIPAVPRT GPLPTSPAQH RLWLLDRLRP
GGNDHNSGRA LRFRGPLDVP KLVRSVQNLV ARHEALRTTF SERDGAAVQV VHPARDVDVP
VVGECDLTAE FARPYDLEHG PLFRALIVRF GPQDHVLLLG AHHIVTDGWS LGVLTDELAA
LYRGERLPEP SIQYADFAAW HREQRWDDAL GRWKDRLAGL SPLELPTDRP RPAERTGAGA
AHRFVVPAAI TGGLEQIARV HDTTLFGTLM AACQVLFARY SGQSDVVLGT VTSGRTRPEL
NRVVGFFVTT AVVRSVVDGR FTDLLRQDHA LHDEVPFEKL VDATGTSRDA SRNPLFDVMV
LLQNTERGLP AFPGLTVEDV PVERWAADFD LTVEFTPRGD ELECVLEYST DLFDAVTVQR
LGEHLLVLLG GVVDDPSRPV HALPLVTRGE LDRMREWNST ALDAPTTTFT AIFEEQARRT
PQATALVCGT EALTYAELDA RANRLAHWLI GEGVRPEQVV GVSLPRTADA IVALLAALKS
GAVYLPIDPD LPRDRQEHLR ADAGAVRVFD ALPDTDDLPA TGPAVRILPS QAAYVIYTSG
STGTPKGVVV EHRNLVNLLH SHVADFAGGE RMRVALTAVF SFDTSWEGPV LMAAGHELHL
LGDDVRLDAD ALVSYVGRHR IDFLDLTPSY LQQLIPAGLL DHHPRVLMLG GEALGERLWR
DLAGTNAHNF YGPTECTVDA VSCRVEGDRP VIGRPLRNLQ AHVLDADLRP VPVGVAGELY
LAGAQVGRGY LGQPGLTASR FLANPFGDDD SSGVRMYRTG DRVRWTAEGH LDYLGRVDDQ
VKIRGFRIEP GEVEAALLRH PDVTDAVVVA RDDRLVGYVV GTRADLRPWL KNSLPDYMVP
AAFVTLDRVP LTGNGKVDRK ALPAPVLARE EFQAPRTPAE ETLAGIWSEV LGVERVGVDD
NFFGLGGDSI LAIQLVSRAR RGGLQLSSRD VFRHQTVAEL ALAAAPAVEV EIAHVEGPAP
LTPIQRWFFE HDGDTGYAMS LAVDVPSGVD VQQALDAVVA HHEALRLRFV DGRMELGARW
PALEVADSFE HRDFDLAIGP LLRAVLVGSR LYLSAHHLII DGVSWRILLE DLAKAWRGEP
LDPPTMPFTQ WAHHLTRQDF RDALPHWRRQ PTGDVAVGER HSFTVSLDAE TTAALLHDVP
GVYHTQINDV LLAALGRREL TLEGHGRDVL DADVSRTIGW FTTQFPVSLD FPGGDWGAVL
KSVKEQLRAI PHKGLSYEAL RYLTPDSGLS GELPDLCFNY HGHWEGGHEV PGPDLARHPV
EVNGMVADGC LRFTWSYAGE SPRAEAERML VSLRAIVEHC RTSPGGHTPS DFPLARLTQE
LLDALPADVE DVYPLTPLQA GMLFHNLLDP AAYVDRLELV LDGVEDPEAL RASWRRVIAR
TPVLRTSIVW EGVDEPVQVV HREASPLLRI DITPSSGSRV RLVWESHHVL LDGWSTAQVF
AEVVAEYRRE PVFARRPFRD YLRWLAEQDT SAAQRYWSEV LDGAEPTPLP YDRKPAEAHQ
AESTESIRVS LSTEDSEALR TAVREHGITV NTVVQGAWAV LLARHSGTRD VVFGTTVSGR
PAELPGVESM IGMFINTVPT RVAVDDDQPA ASWLRDLQQA QSEARTFEHV SLARLGGGLF
DSVVVFENYP FDRESTAAPR VVEVTATDTT TLPITLTAHL GDRLSFDLAY DPRLFDAATA
QRLSERLHVL LSGIATDPRR PVGALPWTVP GELDALLGQT GLETTGGLYH EVFARQAAAT
PDAAAVWPHT FAEVDAAANR LAHRLIADGA GPERLVGLAL PRHDMVVALL AVMKAGAAYL
PIDRDLPPGR REFLLADAKP VLVLDELPDA SAFPAHTPDV EVLPAHPAYV IYTSGSTGTP
KGVVIEHAQL ANLYADHRAT LIPDAPLRVA LTAAFSFDTS WEGLLFLAAG HELHVIGEDL
RLDPPALVGY VREHGIGVMD VTPTYARQLL PAGLLDAGLR TLMLGGEAVD ESLWQEVREI
GLNYYGPTEF AVDATYCALA DHDRPVIGRP GHNVRAYVLD DGLRPVPVGV PGELFLAGAQ
VARGYLGRAG LTAERFVANP FETGSRMYAT GDRVRWLSGG VLDYLGRTDD QVKIRGIRIE
PGEIVAALLD VPGVRQAAVV AVDDRLVAYL VGTPEVEVRE ALSRVLPAHL VPAAFMELAE
LPMTSSGKLD RKALPTPEFA SREFVAPCTG AERVVAAAWA EVLGVERVGA HDNFFALGGD
SILSIRVVAR LRAAFGVQVS PRVLFQHSTV AQLAEGLREG DSATIPVVSR VEVPQSFAQG
RLWFLDQFES GGTEYITPTA LRLRGPLDVP TLSRALTALV ARHESLRTTF TDGLQIIGEP
YEVRLCPEHG DLDAILLEET TAPFNLRTGP LLRTRLVRLG ADEHVLVLTL HHIVTDGWST
AVLTDELAAL YEGRELPALP VQYADFAVWQ RNLDLDAQLR YWGEQLAGVA PLELPTDRPR
PAVRTTSGAM HEFELPVAGL RDGDTTLFMT LVAACQLLFS RYSGQSDVAV GTVTSGRERA
ELENVVGFFV NTVVLRSTVV GRPFGEFLSQ VRQTVLDAFE HQDVPFERVV DAVGPDRDPS
RNPLFDVMVL LQNTADEVPS ITGLAVEEVR LPVVTSTCDL TFEFQQRGDV LLGAVEYNPD
LFDAPTIERM ARHLVVLLGE IAAGREPFLT DDGTLQAGPA LEVSDPPFSH LFERQALLTP
DATALVAAES FTFAELNERA NRLAHRLISL GAGPERLVAL RLPRSADFVV AVLAVLKSGA
AYLPVDRALP AERVELLLRD AQPVVVLDEI GDLDAFPGTD PVVGIDPAST AYVIYTSGST
GTPKGVAVEH RNLTNLVAHH RELFGSRVLR VAHTALFSFD TALEGLALLA CGHELHLVSD
DVRLDAVALV EHVRSQGIDV LDATPAHMRA LIASGLLERA PEIITIGGEA VPPDLWDQLG
DVRAYNFYGP TECTVDATWC RIAGPRPVIG GPLTNQRAYV LDGDLRPVPV GVPGELYVAG
AQVARGYLGR PGLTAERFLA DPFAPKKDFG ARMYRTGDRV RWTDDGQLEF LGRADDQLKI
RGFRVEPGEV EAVLLRHPDV SAAVVVGRDT RLVAYVVGTP ELDDWARRFL PAHLVPSAFV
GLESLPLTPS GKVDRRALPE PHFASREFVA PRTEREVLLA QTWAEVLGLG TVGAEDNFFA
LGGDSILSMQ VVARARVHGL MISSKDVFVH QTVAALAAAA QEAPAPVSHD LVTGPAPLTP
IQHWFFEKVG RDDYTMSLRL ELAPGTDVDA LARAVRVVAE HHEALRLRFT GGRQEARAPV
PQIESTVDGF DLARGPLFRA TLVDGTLLLV AHHLVIDAVS WRILLEDLDT AYRGDPLPPA
TLPFTQWAHQ LNRLAPEFAD ALPYWQSIPL GTATVPAERH HFTVELDEAT TAALLRDVPG
VYRTRINDVL LSALGKAVSP VFALEGHGRD DSVSRTIGWF TSQFPVALEL PDGDWGVVLK
SVKEQLRAIP HDGLSYEVLR YLTPGSGLTG DLPEVCFNYL GQWDDGESDG VFRGRPDTGI
PEVPTHLVEI TAAVDGGRLV LDWDHGLPEA EARGQADDML RALREIVEHC RTSPGGRTPS
DFPLVRLTQE QLDALGEVED VYPLTPLQSG MVFHSIDDAD AYVDRMELLL DVDLDRFRGA
WQRVIARTPA LRADVVWQGV DEPVQVVRPE QSPLLRLDFS QDGDRVRLVW STHHVLLDGW
STAQVFSDVI AEYRGDQPVT RRPFRDHLRW LSGQDTAAAE EYWRRVLDGF TTPTPLPFDR
ELQGPAESSA VLALDLPPAD LREHGLTVNT VVQGAWALLL ARLSGERDVV FGTTVSGRPA
ELPGSDSMIG MFINTVPSRV VVDLRRPVVE WLRDLQAAQS EARAYDHVSL ARLGGELFHS
LLAFENYPVG ADDDLRVDVV ESRDTTTLPL AVRAHADDGA LHFEFTYDPR LFDASTITSL
AGRMALVLRE FTERPDQSLA DVRWTTSKED HRVLVEWNGT ATGRPTATLP ELFESQVSRT
PDRVAVGDLS YTELNARANR LAHRLIADGA GPERFVGLRL PRGTDLVVAI LGVLKSGAAY
LPIDLSYPEE RVARMISDTA PVAVLESLPD LNGFPDTDPV TALGADNPAY VIYTSGSTGA
PKGVVVPHAN VVRLFEQTSD WFSFGEDDVW TLFHSFAFDF SVWELWGPLL HGGRLVVVPH
EVSRSPRTFL RLLHDEQVTV LNQTPSAFYQ LMAEEQVPLA LRYVIFGGEA LDLSRLSAWY
THHDARLVNM YGITETTVHV SYLALDPALA ASAPGSLIGT GIPDLRIYLL DEHLRPVPPG
VTGEMYVGGE GLARGYLDRP GLTASRFVAN PFGSDDSSGA RMYRTGDLAR WRADGDLEYL
GRADQQVKVR GFRIEPGEIE AVLHPAVDQV AVIAKDQRLV AYVVGDTPVD ELRARAAAVL
PEHMVPSAFV RLDRLPLNNN GKLDVRALPE PGRESATTQE FVPPRTDAER AIADIWADVL
GVDRVGVTDR FVELGGDSIS SIRVISRLRA KFGVDLTPRD LFGHPTVEGL ARVLPGRGMT
TIPVVSRKGE LELSFAQQRL WFLDQLTPGG TEYVTPLAVR LTGELDVAAL SAAMSALVAR
HESLRTTFRE VDGRAVQVVH PPAPVEIPVA IGDVEKVLGR EAHTPFDLTT GPLLRPLLIR
VSAREHVLAL TMHHIVTDGW SGGLIMEELS ALYAGQPLPP LAVQYADFAA WQRSLPLDEQ
LGYWRTQLAG VPALELPTDR PRPPTHTTNG ATVEVALPAH GLRELARGQD TTLFTALVAA
CTLLLRRWTG QDDIAVGTVS SGREHPELER LVGFFVNTVT LRSTVDESAS FRELLGAVHG
TVREAFAHQD VPFERVVDAV QPDRDPSRTP LFQVLVALQN APSRAGALPG LVGEDVDLPV
HTASFDVAFE FTEADDELHG TITYNTDLFD HATVELLARH LRVLVDGAVA APALPMAGLL
MLTPAELDQL ESWNEATQEV TPCSFAQLVE RQVARTPDAP ALIHAEGEIS FAELDARANR
LARVLVERGA GPERIVAVQL PRSVDIIVTE LAVLKTGAAF LPIDPDYPAE RVEFMLRDAD
PVVVVDGPLD ASGYDASPLG VPVDLAQPAY VIYTSGSTGR PKGVVVTHAG LASFSAAELE
HFEVRPGDRV LEFSSPSFDA SVLELCMSLP AGAALVVPPE GPLLGDQLAD VLRENKVTHA
LIPPVAMATV PDVPLPDFRT LIVGGDACTA ELVARWAPGR RMINAYGPTE STVVTSWSGP
LVPGGVPPIG RPLPGTRVHV LDSLLRPVPV GVPGELYVSG PQLARGYLGR PGLTAERFLA
NPFDSDDSSG VRMYRTGDVV RWNRDGELEF VGRADDQVKI RGFRVELGEV ESALLRHPSV
REAVVVAQDF GGHKRLVAYV VGLTGELREF LAQTLPDYLV PSAFVAIDEV PMSPNGKVDR
KALPVPEFTA TTTHVAPRND VERALCSLWA DVLAVPEVGV EDNFFALGGD SILSIQVVAR
GRRAGLHFTA KDLFTHQTIA GLAPHVTAES DTGDRADVVG DVPLLPIQRW FFAGDRTAPH
HFNQSHLVEL TSDVDVAALR RALEALVRHH DALRMRFTSG ESGWQQHNPP FEPADVLSEH
PLDDLERVAD ELHAGFDLAR GPLLRAALFG SRRLFLVAHH LVVDGVSWRI LLDDLGTAYH
QALRSEPIDL GRKSTSVRDW AVRLEPFVDS GALDHEIEHW RSITAEPLDA SEEESASSFE
LSAEETDALL RGAPTAYRTG INDVLLAALA WALARWTGTP SVTIDLEGHG REEVLDDVDL
SRTVGWFTTM FPVGLEVSDV TDSSWRDRVK SARKQLRRVP GNGFGYGPLR WAGRVPGVEA
PVSFNYLGQF DARAEDESLF GEVLPAVGRD HVDQDPHVVQ VVGEVADGRM TFGVVHRVPV
AGLVGDFAAA LRAIAADCRE AR
//
