ID A0A1W2CSY1_9PSEU Unreviewed; 416 AA.
AC A0A1W2CSY1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=SAMN05660733_02264 {ECO:0000313|EMBL:SMC88046.1};
OS Lentzea albidocapillata.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Lentzea.
OX NCBI_TaxID=40571 {ECO:0000313|EMBL:SMC88046.1, ECO:0000313|Proteomes:UP000192840};
RN [1] {ECO:0000313|Proteomes:UP000192840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44073 {ECO:0000313|Proteomes:UP000192840};
RA Varghese N., Submissions S.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
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DR EMBL; FWYC01000006; SMC88046.1; -; Genomic_DNA.
DR RefSeq; WP_030479056.1; NZ_JOEA01000014.1.
DR AlphaFoldDB; A0A1W2CSY1; -.
DR STRING; 40571.SAMN05660733_02264; -.
DR eggNOG; COG3486; Bacteria.
DR OrthoDB; 7527071at2; -.
DR Proteomes; UP000192840; Unassembled WGS sequence.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
SQ SEQUENCE 416 AA; 46405 MW; EC77374EED8E1E58 CRC64;
MEPVLDLAGI GFGPSNLALA IAVEEHALPV RARFFERQPC FGWHRGMLLE DATMQVSFLK
DLVTLRNPTS GFSFLCYLRD RGRLIDFVNH KNLFPLRKEF HDYFEWAAER VGHHVSYGAE
VSQVRAVDDG FEFTAAGQQV RTRNLVLATG LEANLPDGIE PSDRIWHNKD LLTRVDTLKD
PRQVVVVGAG QSAAEAVAFF HDRFPQAEVH GVFARYGYSP ADDSSFANRI FDPAAVDDFY
AAPEEVKRRL MGYHANTNYG VVDGDLIEEL YRRVYREKVV GRQRLLLHNT SKLTDVTTDG
KCVVESLADG GRLPIDADVI VYATGYRPAN PLRLLGDLAG HCERDDIGRL KVTRDYRVVT
DDGLRGGIYL QGGTEHTHGI TSSLLSNTAV RVGEILDSVL RRVAQQQAEP KLQAVK
//
