ID A0A1W2D8M2_9FIRM Unreviewed; 3315 AA.
AC A0A1W2D8M2;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=LPXTG-motif cell wall anchor domain-containing protein {ECO:0000313|EMBL:SMC93850.1};
GN ORFNames=SAMN06297397_0111 {ECO:0000313|EMBL:SMC93850.1};
OS Clostridiales bacterium.
OC Bacteria; Bacillota; Clostridia; Eubacteriales.
OX NCBI_TaxID=1898207 {ECO:0000313|EMBL:SMC93850.1, ECO:0000313|Proteomes:UP000192328};
RN [1] {ECO:0000313|Proteomes:UP000192328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WTE2008 {ECO:0000313|Proteomes:UP000192328};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:SMC93850.1}.
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DR EMBL; FWXZ01000011; SMC93850.1; -; Genomic_DNA.
DR OrthoDB; 2237794at2; -.
DR Proteomes; UP000192328; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1140; Collagen-binding surface protein Cna, B-type domain; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR008454; Collagen-bd_Cna-like_B-typ_dom.
DR InterPro; IPR046022; DUF5979.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR041033; Prealbumin-like.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR Pfam; PF05738; Cna_B; 3.
DR Pfam; PF19407; DUF5979; 3.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF17802; SpaA; 1.
DR SUPFAM; SSF49478; Cna protein B-type domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Secreted {ECO:0000256|ARBA:ARBA00022512}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..40
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 41..3315
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012868066"
FT TRANSMEM 3286..3305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1863..1926
FT /note="CNA-B"
FT /evidence="ECO:0000259|Pfam:PF05738"
FT DOMAIN 1937..2040
FT /note="DUF5979"
FT /evidence="ECO:0000259|Pfam:PF19407"
FT DOMAIN 2046..2154
FT /note="DUF5979"
FT /evidence="ECO:0000259|Pfam:PF19407"
FT DOMAIN 2300..2377
FT /note="CNA-B"
FT /evidence="ECO:0000259|Pfam:PF05738"
FT DOMAIN 2916..3034
FT /note="DUF5979"
FT /evidence="ECO:0000259|Pfam:PF19407"
FT DOMAIN 3040..3135
FT /note="CNA-B"
FT /evidence="ECO:0000259|Pfam:PF05738"
FT DOMAIN 3174..3247
FT /note="Prealbumin-like fold"
FT /evidence="ECO:0000259|Pfam:PF17802"
FT DOMAIN 3277..3309
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|Pfam:PF00746"
FT REGION 50..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..91
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3315 AA; 365780 MW; 230B2190875C8FAB CRC64;
MFNRNDPERK IRQVKGWRRL TAFLCAFMLL FSSCGLNAFA QTIYSDPVTV PAQNTESPEE
TPAPADAAVT GEDAEPVIDE SAAEDAAEVP GTDEPGEPAG ETPAEDVPAS GTDVEQPEGP
DEEETAAEAG DNTNNDQTEE IGAEPGIEYF PGTLTLETAE GSVRIEYPAE ARLPENTVLS
LMPVKGTELY AALKSAAKLI RNEENDTWQR QVADEGNRFW MPALKDTDGN ELRPQAGVTL
SFTTHEAPKG AEWFRAGDNA GILEVQDGTV TITDYGMEPF GYALLERVQI GTVTQEYSAG
DYTVTASYGP DAGFPEDTEM KVREIRPGTP EYALYSGMTE ETLGEEWSEI TLERYFDITF
VSGGEEVEPQ ADVDVQILFR DIIELTEEHD VQAVHIENHE AVVIESETDS NEDSAKRNSE
AIDTVSFTAD SFSVFGVVQR KKITQKVLAA DGNTYEISVI YGPDAEIPAD AELAVTELQP
GDPQYAEHLR KAVKAALEQS DRISGDEPVY INEDQYGRFF DIEIRSGGQK IEPDGNVSVK
ISLADAPEER TDELLVVHFA EAEPDILTAD IGTETGIQFE ADSFSVYGVI TMPSSTPQND
LGDLDSRRFT MSHNGQYVTS TVDLGTTNQL HKTRNANEAT VWTFEATDTA GIYNIFTTDA
QGNKLYMNLN RRDPSRAHGA VSSTPQGFGV TRDSNGKYLI SASIGSDTYW LNEFNAGTGF
AGWYQRSAGY DLLDLQFADP VMENGKEYMV LAKYDGNYYI VNNDATLTPV DYDPVANRVA
VDNPMLWTVD GTNPNRHIYF RSEAAGYTSD QLPSDYYRRY LDPSQANALS EENSGNVTLD
PHSNQAWRDD EGHINYPNTI IRPTDAERSS NVNYYSQQVY TQPWNGNNHL GVELNSHGVP
VRLVGQQSAD NGVEILFADP TKVGDPIARN HSVNHIDISI AGESRVNVPL AYGTYYYRDP
DTGAMIEYNV TTNTTLNLST KVSIDPEDMK HATIKAYDKN NNELDDAFVI TGYSSNAHND
VSAVQVRVEG RFKVAEVSTA YNWWEDTNSD RMKRERLNNQ ITYVVSAVKN EDFNMVDPDR
GQLYEKMADG TYKPLSLNMD VDMTASFTYY DKLNECPPVR WNYDLWQSGG IIDGSGMDFV
LGGDTEAAST SVVALEVTKQ IVDENGMLVH PAEKIIHSVD IYGNTAKDAN GLVANPNIVA
EVNVNQYGTE FVPSGYTKYH SKNIAVGPNG MTVVYDYAIK PGMYYVTEDK STIAQTFVDT
SGDTWEYKET YIATEYVRRG NKYDDKEAYP DPRHLSKIYT MDDPVYAAVP EVVGTFKTLN
NVEKKNGIVE FYVYNVYVNT SHTSLEVEKL WADGTPVPAN AVVTFDLYYA KRQKTNNGEP
VANLAPWPDY EEYLPVDGDP IFDPTIQKVL TMSTNEAAED WTGTFTGMPA NWRDADGNEW
ELDYFAKEAA LTVDGENIIS QYNQTAEKEE PAPEEVDFSD GKVIITNAAA RTETTVKKNW
SDDAAHYDDE SITLKLVRYR KEAPPEPEEG VLHISHITSG IPASPELPAG FTATYSYVGP
VSASGVPAGS YSVPPGRYTV TATVTNGGAP FGYTYSFTSD PVTVNVHENG VVTTEFTSFY
SQNAGTLNIT HASAGLSNSP ALPAGFAVTY SCTGNGSTYQ LQPGENTLPA GTYVVTANVS
NGAPPSGYSY ASTTEPMTVT VYSNGTTNAA FTSYYGRFVK VTAKHIQQRG VSWNIITDVY
EKEFAVGTII EIAYSTNYLD SELYINGQRV TTFHGDGRHT YSYTIQREGD ILIEALDPWF
PNGFTTKITV EAIGVSGRTD ERHGLTAGLR AARYTASAGF TSGGSRLRAS GLPEGYSRDE
DWSETVTVSL SEDWTKVVSE LDVYDEHGQP YYYAVEEENI PAGYDSEAGA PVSAVDIEDA
VLTVTNTYIN PTTGNLIVSK KITGNAADLT EEFTFTVTVT DAEGQPIPDG DYGAMTFSGG
TATFTLTNGE MKKALELPEG AIFTVTEDPK GYTAVQAGGE DGDNVIEAGG TKHVDFTNTL
DTFADLKISK TVTGEEINED QVFVFTVTLP GHTGEETFDT VMASGGEDRE GSLTFTDGTA
TVELKHNESL TIKNLPNGTD YVITEDNYTP EYYEPQIENA SGTIEGGENV TVDASFINPK
VPVVDITANK DWGTADYILE ATAVQFVLKR TAGDGEPEVV DTVTLKAEDN WQVYWEGLDK
YVNGELPEEE RTAYTYSVEE TGVYFGELVD GEVPEDGWVT DGETLAAMYK TEGGAVTMTG
DYLNHGMATI TNETETATVI VEKNWPDFAD DDSFTWEAAF QLLADETPTG DHLIIRKDTP
AEERTFANLP KFAVDENGEA KLIDYTVRET SYSVYENGEL QFSYDGTNYI PDDRYKRYLS
SYDSEFNEDG EEVITVTNVT TKVKSIRVTK EWMGVPIEET KDLPAASFAL AYIPATGWGN
PQPYEDDTGF DYTRIWLSYK NNWTWECPVD LPEEYRYFVI ETPLTKPNWD SADEHVRTDP
LIDEFPIMIE GYKCRDVIDT GNWSSLVHFQ QPRNANIGNH GEIKILNKLP GYMQMDLKKK
FLEYRDNGNG GQSLYTTTGE DQAQSNMIIE LQMMRRTIDY SSGEDVYITG WQNYGKPIKL
GYDAAGNDYV DNPNPFSVSS RGSWNFNVED NNIYHGLPTK GLYRKADNSI IVVRYQYIYK
EVQVYDGNLN PIGGQWTSWL PYAWDANGNK VRVSELQTAQ DQDRMLNAPG TSLDIEKGWA
DNRVAANVEE VYVRVERREY GSNGPYEDYL SVISTETELG SLGQNHFITS GPDVYNPVTN
RIVLNRNNDW KATIDKVQIF PNGNGAKQYE YRIIETGYMD LAGNVYLNTE AFEPITYYKH
GHNEGDWVKQ GSGVLLSREG PNKLKVENTS HFGPLQLTKQ VPEASTEAAE EQTFEFHVEM
LLPPGMELKP LDLVVENGTI SDFTCEGEVA EFTVSIQGQG TVFIDGIPFG TTYEVTEPSV
PEGWKQDGET VYSDEEGKQI ALGDDPFDSV IITNIEVTSI SAEKTWKQNG VTVDWPAEVT
EITAGLYGSV NGGEPEPVED EEGNPRRLTF GQNAKIADRT FTELPVYDEE GNPITYSIRE
ESISGGQETA DITDGVVTLA GKTWQALAGE PDEDNHVVIT NSRTEIHLLK TDANTNEALA
DAEFRLMKLN GDSWEVFMDG ITVGSEGEEK GRAAVDGLTE GSYTLMEMKA PAGYIALGMP
VGFRVRNGEI LFDNTGHVTY DADTATFTVR NKPGLALPST GGEGTLVYTA CGLGMILLAV
ILLMVRRKKW KNNCM
//
