ID A0A1W2DHV5_9SPHI Unreviewed; 1058 AA.
AC A0A1W2DHV5;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Error-prone DNA polymerase {ECO:0000256|ARBA:ARBA00017273};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=SAMN04488524_3830 {ECO:0000313|EMBL:SMC96984.1};
OS Pedobacter africanus.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=151894 {ECO:0000313|EMBL:SMC96984.1, ECO:0000313|Proteomes:UP000192756};
RN [1] {ECO:0000313|Proteomes:UP000192756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12126 {ECO:0000313|Proteomes:UP000192756};
RA Varghese N., Submissions S.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC subfamily. {ECO:0000256|ARBA:ARBA00007391}.
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DR EMBL; FWXT01000003; SMC96984.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W2DHV5; -.
DR STRING; 151894.SAMN04488524_3830; -.
DR Proteomes; UP000192756; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07434; PHP_PolIIIA_DnaE2; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR HAMAP; MF_01902; DNApol_error_prone; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR023073; DnaE2.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000192756};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 17..84
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1058 AA; 119898 MW; 47439A4353A91361 CRC64;
MVYTWIFCLE EPLMQYTELQ VTTNFSFLRG GSHPEELVKQ AAALGHKEIA ITDRNTLAGI
VRAHVAARGK NIRVIPACHL ELLDGPPLLA YPTDRAAYSR LSTLLSEGNL RAEKGQCHLY
KADVYRYAEG IKFIAIAPIN LNSGFDFDPE FKQALKTYRW ALGTHLYLAA SRSYQANDGK
RLFRLSQLSD ELRIPLIAVN DVHYHIPQRR ELQDILTCIR EKCTIYNAGF RLHQNAERYL
KPIAEMHRLF SQYPQALERT QEIAEACQFS LDSLEYVYPE ELTTEGRNPQ QELVHLTWQG
AKEKFGNKIP PEICETIRYE LDFMERKNYA AYFLTVYDFV RFARSQNILC QGRGSAANSV
VCYCLGITSV DPSKFKVLFA RFMSDARDEP PDIDVDFEHE RREEVMQYIY SKYGRDRSAI
VATVTQVHYR GAVRDVAKVM GLSVDTINRL ASSAWEFTDE WHNGRTVSSE GFDASDPHLK
KVLELTQQYI GFPRQLGQHT GGFVMTRGKI TDLCPILNAR MENRTCLEWN KDDIEALGFL
KVDVLALGML TCIRKAFDLA KQHYGLNLTL ANVPQDDPEV YEMISHADTL GVFQIESRAQ
MSMLPRLRPK CFYDLVIEVA IVRPGPIQGD MVHPYLRRRN GEEPIEYPSK ELETILGRTL
GVPLFQEQAM EIAIVAAGFT PAEADGLRRS MATFKSHGKV SEWRNKLVSG MVAKGYKEEF
AQRVFKQLEG FGSYGFPESH AASFALLVYI SSWIKCHYPD VFATALLNSM PMGFYQPAQI
VIDARKHGVE VRPADVNHSS WDNLLETKSG RYHPIRLGFR QIKGLNEEEM QVLLAARQSP
FTSIHALLNA GVSLAALERL ADADAFRSLG LDRRQALWEV SALSDSPVGM FEGQVQESRH
EKEVGLPVMS LSEHVVQDYN STTLSLKAHP LSFVREKLNL LKVLPIRELD QHADGDIVKV
SGLVLVRQRP GTATGVCFIT IEDETGFANL VVFKKWFDKY RKEILRAKLL MVEGKLQREG
EVTHVVVTCC SDQSAYLNAL TEVENNGSGI FHEGRNFK
//