ID   A0A1W2DIX7_9SPHI        Unreviewed;       443 AA.
AC   A0A1W2DIX7;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Zinc metalloprotease {ECO:0000256|RuleBase:RU362031};
DE            EC=3.4.24.- {ECO:0000256|RuleBase:RU362031};
GN   ORFNames=SAMN04488101_1079 {ECO:0000313|EMBL:SMC96896.1};
OS   Pedobacter nyackensis.
OC   Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC   Sphingobacteriaceae; Pedobacter.
OX   NCBI_TaxID=475255 {ECO:0000313|EMBL:SMC96896.1, ECO:0000313|Proteomes:UP000192678};
RN   [1] {ECO:0000313|EMBL:SMC96896.1, ECO:0000313|Proteomes:UP000192678}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19625 {ECO:0000313|EMBL:SMC96896.1,
RC   ECO:0000313|Proteomes:UP000192678};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU362031};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family.
CC       {ECO:0000256|ARBA:ARBA00007931, ECO:0000256|RuleBase:RU362031}.
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DR   EMBL; FWYB01000007; SMC96896.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W2DIX7; -.
DR   STRING; 475255.SAMN04488101_1079; -.
DR   OrthoDB; 9782003at2; -.
DR   Proteomes; UP000192678; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00989; PDZ_metalloprotease; 1.
DR   CDD; cd06163; S2P-M50_PDZ_RseP-like; 2.
DR   Gene3D; 2.30.42.10; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   NCBIfam; TIGR00054; RIP metalloprotease RseP; 1.
DR   PANTHER; PTHR42837:SF2; MEMBRANE METALLOPROTEASE ARASP2, CHLOROPLASTIC-RELATED; 1.
DR   PANTHER; PTHR42837; REGULATOR OF SIGMA-E PROTEASE RSEP; 1.
DR   Pfam; PF13180; PDZ_2; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362031};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362031};
KW   Metal-binding {ECO:0000256|RuleBase:RU362031};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU362031};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SMC96896.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192678};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362031};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362031};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU362031}.
FT   TRANSMEM        104..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362031"
FT   TRANSMEM        365..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362031"
FT   TRANSMEM        419..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362031"
FT   DOMAIN          121..192
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
FT   DOMAIN          210..280
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
SQ   SEQUENCE   443 AA;  48645 MW;  C7269ECB63A6E507 CRC64;
     MSGLIMAAQL LLGLSILVIL HELGHFLAAR AFGIKVEKFY LFFDAWGFKL FSFKKGDCEY
     GIGWLPLGGY VKIAGMIDES MDTEQMNQPA QPWEFRSKPA WQRLIVMLGG VVVNIIVGIF
     IFWMLTFKYG ETYIANSSVQ NGINPGSIGK EIGLQKGDRV IAVNGNKVIR FEELMSSKVL
     LGNTSLTIVR GDKTMDIKVP DNILNKVSDL GIEAFISRAP LLTSTVDSII AGKAAFKAGL
     QKGDRITAIN SVPVKYDADV RELIPKFKGK SVTFDVNRGA QHLTYTVPVD TAGTIGIGFN
     INEIKEETIK YGLIAALPIG ANQAWKTFSD NAKGIWKVLT GKIQANKAFS GPVEIARKVY
     GGEWIWARFW ASTGFISIAL AFMNLLPIPA LDGGHVVFLL VEMVKGKPLG DKFMERAQIA
     GFVILLSLMV FVLGNDIFKA FFK
//