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Database: UniProt
Entry: A0A1W2GYI4_9BACT
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ID   A0A1W2GYI4_9BACT        Unreviewed;       963 AA.
AC   A0A1W2GYI4;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Glycine dehydrogenase (decarboxylating) {ECO:0000256|HAMAP-Rule:MF_00711};
DE            EC=1.4.4.2 {ECO:0000256|HAMAP-Rule:MF_00711};
DE   AltName: Full=Glycine cleavage system P-protein {ECO:0000256|HAMAP-Rule:MF_00711};
DE   AltName: Full=Glycine decarboxylase {ECO:0000256|HAMAP-Rule:MF_00711};
DE   AltName: Full=Glycine dehydrogenase (aminomethyl-transferring) {ECO:0000256|HAMAP-Rule:MF_00711};
GN   Name=gcvP {ECO:0000256|HAMAP-Rule:MF_00711};
GN   ORFNames=SAMN00777080_0298 {ECO:0000313|EMBL:SMD41767.1};
OS   Aquiflexum balticum DSM 16537.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC   Aquiflexum.
OX   NCBI_TaxID=758820 {ECO:0000313|EMBL:SMD41767.1, ECO:0000313|Proteomes:UP000192333};
RN   [1] {ECO:0000313|EMBL:SMD41767.1, ECO:0000313|Proteomes:UP000192333}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16537 {ECO:0000313|EMBL:SMD41767.1,
RC   ECO:0000313|Proteomes:UP000192333};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC       glycine. The P protein binds the alpha-amino group of glycine through
CC       its pyridoxal phosphate cofactor; CO(2) is released and the remaining
CC       methylamine moiety is then transferred to the lipoamide cofactor of the
CC       H protein. {ECO:0000256|ARBA:ARBA00003788, ECO:0000256|HAMAP-
CC       Rule:MF_00711}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage
CC         complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-
CC         L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304,
CC         Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099,
CC         ChEBI:CHEBI:83143; EC=1.4.4.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00033655, ECO:0000256|HAMAP-
CC         Rule:MF_00711};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|HAMAP-Rule:MF_00711, ECO:0000256|PIRSR:PIRSR603437-50};
CC   -!- SUBUNIT: The glycine cleavage system is composed of four proteins: P,
CC       T, L and H. {ECO:0000256|ARBA:ARBA00011690, ECO:0000256|HAMAP-
CC       Rule:MF_00711}.
CC   -!- SIMILARITY: Belongs to the GcvP family. {ECO:0000256|ARBA:ARBA00010756,
CC       ECO:0000256|HAMAP-Rule:MF_00711}.
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DR   EMBL; LT838813; SMD41767.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W2GYI4; -.
DR   STRING; 758820.SAMN00777080_0298; -.
DR   OrthoDB; 9801272at2; -.
DR   Proteomes; UP000192333; Chromosome i.
DR   GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:UniProtKB-UniRule.
DR   CDD; cd00613; GDC-P; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 2.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 2.
DR   HAMAP; MF_00711; GcvP; 1.
DR   InterPro; IPR003437; GcvP.
DR   InterPro; IPR049316; GDC-P_C.
DR   InterPro; IPR049315; GDC-P_N.
DR   InterPro; IPR020581; GDC_P.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR00461; gcvP; 1.
DR   PANTHER; PTHR11773:SF1; GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11773; GLYCINE DEHYDROGENASE, DECARBOXYLATING; 1.
DR   Pfam; PF21478; GcvP2_C; 1.
DR   Pfam; PF02347; GDC-P; 2.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 2.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, ECO:0000256|HAMAP-
KW   Rule:MF_00711};
KW   Pyridoxal phosphate {ECO:0000256|HAMAP-Rule:MF_00711,
KW   ECO:0000256|PIRSR:PIRSR603437-50};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192333}.
FT   DOMAIN          13..441
FT                   /note="Glycine cleavage system P-protein N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02347"
FT   DOMAIN          478..737
FT                   /note="Glycine cleavage system P-protein N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02347"
FT   DOMAIN          781..901
FT                   /note="Glycine dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21478"
FT   MOD_RES         709
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00711,
FT                   ECO:0000256|PIRSR:PIRSR603437-50"
SQ   SEQUENCE   963 AA;  105853 MW;  00EEA8AB1A7EEF60 CRC64;
     MKIKLDPSTK FEQRHNGPSP KEVQLMLQSI GAASLDELID QTIPKAIQLV KPLDLPKSKT
     EASFLRDFKK LALKNKIFKS FIGLGYYDTI VPGVILRNIL ENPGWYTAYT PYQAEIAQGR
     LEALINYQTM VMDLTGMEMA NASLLDEATA AAEAMTMLYA SKPREKKNAN KFFVDEKIFP
     QTKDLLITRA EPIGIELVIA PLSSLDLTEA NLFGMLLQYP NLDGAVIDHS QLVAAAKENN
     VLTAFATDLL SLTLLTPPGE IGADVVVGTS QRFGVPMGYG GPHAAFFATK EAYKRQVPGR
     IIGVSVDRDG NKAYRMALQT REQHIKREKA TSNICTAQVL LAVMAGMFAV YHGPKSLKEI
     AARTHGLAQL TAKALALLGY KQLNENFFDT IKIKTDAVQQ SKIKAFALSS EMNFRYEEGA
     VVLAFDQAKT ISDVKAVVEV FSKSINNKVQ FDWNTMIAEL ELNYPTGLSR TSEYLTHPVF
     NLYHSEHEML RYIKRLENKD LSLVHSMISL GSCTMKLNAT AEMVPVTWPE FGQLHPFCPQ
     DQAAGYYELF QNLRNWLSEI TGFSDTSLQP NSGAQGEYAG LMVIRAYHMS RGDHHRNIAL
     IPTSAHGTNP ASAVMAGMKV VLVKCDESGN IDVEDLKSKA EAHKDELASL MVTYPSTHGV
     FEEAIQEICQ IIHDNGGQVY MDGANMNAQV GLTSPGRIGA DVCHLNLHKT FCIPHGGGGP
     GMGPICVAEH LVPFLPGNPL IETGGTSAIT AISAAPYGSA SILPISYAYI AMMGGDGLTN
     ATKIAILNAN YIKSRLEKHY PILYTGKGGR AAHEMILDCR AFKEVGVEVE DIAKRLMDYG
     FHAPTVSFPV AGTLMIEPTE SETMAELDRF CDAMIGIREE IQEVYDGKAD KENNVLKNAP
     HTAVLALSDN WDFPYSREKA VYPLPFVKGN KFWPSVRRVD SAYGDRNLVC SCIPVEEYAE
     TEV
//
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