ID A0A1W2P757_MOUSE Unreviewed; 74 AA.
AC A0A1W2P757;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=TLE family member 5, transcriptional modulator {ECO:0000313|Ensembl:ENSMUSP00000151523.2};
DE Flags: Fragment;
GN Name=Tle5 {ECO:0000313|Ensembl:ENSMUSP00000151523.2,
GN ECO:0000313|MGI:MGI:95806}; Synonyms=Aes {ECO:0000313|MGI:MGI:95806};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000151523.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000151523.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000151523.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000151523.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000151523.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR ProteomicsDB; 345315; -.
DR Antibodypedia; 10920; 428 antibodies from 36 providers.
DR Ensembl; ENSMUST00000220348.2; ENSMUSP00000151523.2; ENSMUSG00000054452.11.
DR AGR; MGI:95806; -.
DR MGI; MGI:95806; Tle5.
DR VEuPathDB; HostDB:ENSMUSG00000054452; -.
DR GeneTree; ENSGT01030000234519; -.
DR ChiTaRS; Aes; mouse.
DR Proteomes; UP000000589; Chromosome 10.
DR Bgee; ENSMUSG00000054452; Expressed in embryonic brain and 273 other cell types or tissues.
DR ExpressionAtlas; A0A1W2P757; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF4; TRANSDUCIN-LIKE ENHANCER PROTEIN 2; 1.
DR Pfam; PF03920; TLE_N; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|EPD:A0A1W2P757,
KW ECO:0007829|MaxQB:A0A1W2P757};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 10..71
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT COILED 18..45
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000151523.2"
SQ SEQUENCE 74 AA; 8849 MW; 0D94F8128E846136 CRC64;
XGSSHLPQQL KFTTSDSCDR IKDEFQLLQA QYHSLKLECD KLASEKSEMQ RHYVMYYEMS
YGLNIEMHKQ CPRY
//
