ID A0A1W2P7B9_MOUSE Unreviewed; 240 AA.
AC A0A1W2P7B9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Potassium voltage gated channel, Shaw-related subfamily, member 2 {ECO:0000313|Ensembl:ENSMUSP00000151560.2};
GN Name=Kcnc2 {ECO:0000313|Ensembl:ENSMUSP00000151560.2,
GN ECO:0000313|MGI:MGI:96668};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000151560.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000151560.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000151560.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000151560.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000151560.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A1W2P7B9; -.
DR SMR; A0A1W2P7B9; -.
DR ProteomicsDB; 338991; -.
DR Antibodypedia; 17155; 294 antibodies from 30 providers.
DR Ensembl; ENSMUST00000218445.2; ENSMUSP00000151560.2; ENSMUSG00000035681.8.
DR AGR; MGI:96668; -.
DR MGI; MGI:96668; Kcnc2.
DR VEuPathDB; HostDB:ENSMUSG00000035681; -.
DR GeneTree; ENSGT00940000157371; -.
DR ChiTaRS; Kcnc2; mouse.
DR Proteomes; UP000000589; Chromosome 10.
DR Bgee; ENSMUSG00000035681; Expressed in lateral geniculate body and 114 other cell types or tissues.
DR ExpressionAtlas; A0A1W2P7B9; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR PANTHER; PTHR11537:SF172; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY C MEMBER 2; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 1: Evidence at protein level;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Proteomics identification {ECO:0007829|MaxQB:A0A1W2P7B9,
KW ECO:0007829|ProteomicsDB:A0A1W2P7B9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 54..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..83
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 140..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 240 AA; 26255 MW; FED5CC764CBE40F2 CRC64;
MIYYAERVGA QPNDPSASEH TQFKNIPIGF WWAVVTMTTL GYGDMYPQTW SGMLVGALCA
LAGVLTIAMP VPVIVNNFGM YYSLAMAKQK LPRKRKKHIP PAPLASSPTF CKTELNMACN
STQSDTCLGK ENRLLEHNRS VLSGDDSTGS EPPLSPPERL PIRRSSTRDK NRRGETCFLL
TTGDYTCASD GGIRKGYEKS RSLNNIAGLA GNALRLSPVT SPYNSPCPLR RSRSPIPSIL
//
