ID A0A1W2PQ54_HUMAN Unreviewed; 480 AA.
AC A0A1W2PQ54;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Zinc finger protein 577 {ECO:0000313|Ensembl:ENSP00000491936};
DE Flags: Fragment;
GN Name=ZNF577 {ECO:0000313|Ensembl:ENSP00000491936};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000491936, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000491936, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000491936}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (APR-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AC005946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC011460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC074141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1W2PQ54; -.
DR SMR; A0A1W2PQ54; -.
DR MassIVE; A0A1W2PQ54; -.
DR PeptideAtlas; A0A1W2PQ54; -.
DR Antibodypedia; 19054; 73 antibodies from 21 providers.
DR Ensembl; ENST00000638348; ENSP00000491936; ENSG00000161551.
DR HGNC; HGNC:28673; ZNF577.
DR OpenTargets; ENSG00000161551; -.
DR VEuPathDB; HostDB:ENSG00000161551; -.
DR OMA; EFAQGIS; -.
DR ChiTaRS; ZNF577; human.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000161551; Expressed in left testis and 132 other cell types or tissues.
DR ExpressionAtlas; A0A1W2PQ54; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23226:SF398; ZINC FINGER PROTEIN 715; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 23..94
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 158..185
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 186..213
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 214..241
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 242..269
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 270..297
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 298..325
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 326..353
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 354..381
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 480
FT /evidence="ECO:0000313|Ensembl:ENSP00000491936"
SQ SEQUENCE 480 AA; 54395 MW; ABF8D5F084255D36 CRC64;
MKNATIVMSV RREQGSSSGE GSLSFEDVAV GFTREEWQFL DQSQKVLYKE VMLENYINLV
SIGYRGTKPD SLFKLEQGEP PGIAEGAAHS QICPGFVIQS RRYAGKDSDA FGGYGRSCLH
IKRDKTLTGV KYHRCVKPSS PKSQLNDLQK ICAGGKPHEC SVCGRAFSRK AQLIQHQRTE
RGEKPHGCGE CGKTFMRKIQ LTEHQRTHTG EKPHECSECG KAFSRKSQLM VHQRTHTGEK
PYRCSKCGKA FSRKCRLNRH QRSHTGEKLY GCSVCGKAFS QKAYLTAHQR LHTGDKPYKC
SDCGRTFYFK SDLTRHQRIH TGEKPYECSE CEKAFRSKSK LIQHQRTHTG ERPYSCRECG
KAFAHMSVLI KHEKTHIRET AINSLTVEKP SSRSHTSLYM SELIQEQKTV NTVPIEMPSS
GTPPLLNKSE RLVGRNVVIV EQPFPRNQAF VVNQEFEQRI SLTNEVNVAP SVINYILYLT
//
