ID A0A1W2TEP1_ROSNE Unreviewed; 4928 AA.
AC A0A1W2TEP1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=SAMD00023353_1900700 {ECO:0000313|EMBL:GAP86507.1};
OS Rosellinia necatrix (White root-rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Xylariaceae; Rosellinia.
OX NCBI_TaxID=77044 {ECO:0000313|EMBL:GAP86507.1};
RN [1] {ECO:0000313|EMBL:GAP86507.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W97 {ECO:0000313|EMBL:GAP86507.1};
RA Kanematsu S.;
RT "Draft genome sequence of Rosellinia necatrix.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; DF977464; GAP86507.1; -; Genomic_DNA.
DR STRING; 77044.A0A1W2TEP1; -.
DR OMA; ILEQWHR; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000054516; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 9.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000054516}.
FT DOMAIN 4715..4916
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 4082..4604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4082..4096
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4107..4140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4141..4156
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4164..4187
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4188..4240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4255..4269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4280..4308
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4319..4335
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4351..4373
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4401..4435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4436..4450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4494..4511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4561..4588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4928 AA; 553160 MW; C1D2C21F4A25984C CRC64;
MADVDVSLQR AQLLDDEALL GQLPPELLEI IRNQTAANFL DAIAAAALIP QTTSPVFIYF
EHVFADICAR WLLKPRNFGQ EDQIIAAFAR ILPFAPHLSV FLEQYISETS VAQFPGARPF
TLNSLNSLYT GHLSGPDLSR ALVAFWRLVN FDRETYGPLV QPSQVQALFK HELASVRYLA
VKVLCCQLNA SDLKEEELMQ IHVNHESIPA ESLCSDLDGM HVDYAFLSLF EHKRAMEMDK
FRSEVKKSCA ARSTVARIPL QRLTDQVIQY GNVILPRPAG SPSSQSSLVH TPTTLANLES
LAGNLQKPGP ILLHGLPGSG KTSVVQELAR ELGMESSMVT LHLNEQTDAK MLIGLYSTDS
KPGSFSWRPG VLTTAVREGR WVLIEDLDRA PNELMSTLLP LVEHERLLIP SRGETIRATS
TFRLFATVRT TKGAHGQENI PNFLGQRFWN LSSMKIPSYE ELEQIALGSY PLLHKYIPTI
MSVYKRLCSI LSMSFARTIE RPVTPRDLLK WCRRLKEILI AANCKTGEEP ISERTRDWMF
MEAADCFCGG LAKQDTKRLL LSCIAEEMHL PKQLMEHYLD AYVPQMDDSS SNFKIGRVML
MKKHQGNRVV KSKKPFANTS HAKRLLEQIA VAVKLREPVL LVGETGIGKT TVVQQLADTL
GHRLVAVNLS QQSEIGDLIG GFKPVNARSL AVPLREEFED LFASTGISAT KNQKYLEQIG
KCTAKGQWSR VSKLWREAPK MFGRIVDELQ AKSATRSGDL NDVPAMKRRK TESKLQSLLD
LRPRWDMFSK NLDQFDVQVS GGSGNFAFAF VEGNIVKAAR NGDWVLLDEI NLASPDTLES
IADLLASGPN DQPSILLSET GEIERVKAHP SFRLFGAMNP ATDIGKRDLP LGLRSRFTEL
YVGSPDKDLK DLLTIIRAYL SGRSAKDDQA ADDIAKLYMN TKRRAEEKRL VDGANEVPHF
SLRTLTRVLT YVNDVSPFYG LRRSLFEGFS MGFLTLLDKA SEELLVPLIH HHLLDKHGNA
RSLLSQPPKH PSDGKEYVKF LNKNKDRHYW LLQGAETPVE HSDYIITPYI ERNLLNLVRA
TSTRRFPILI QGPTSAGKTS MIEYLANYSG NKFVRINNHE HTDLQEYLGT YVSDASGKLR
FQEGLLVQAL RQGHWIVLDE LNLAPTDVLE ALNRLLDDNR ELLIPETQEF VRPHENFMLF
ATQNPAGLYG GRKALSRAFR NRFLELHFDD IPEDELETIL QKRSIYTAPS DCKRIVNVYK
ELSRLRQTSR LFENKDSFAT LRDLFRWALR GAESREEIAA NGFMLLAERV RNGEERLAVK
QVIEAVFKVQ IDQDQLYDLQ RSPYLRTQPP DNSQGIVWTQ AMRRLYVLVA SALRHNEPVL
LVGETGCGKT TVCQILAESM GKQLHIVNAH QNTETGDLIG SQRPVRNRGA IIDTLTNDVV
QALQTLQRNA NGDTGILLSE YHALGSTLLS NLPEDIRQRI FDNEIKSKAL FEWADGSLVQ
AMRNGQYFLL DEISLADDSV LERLNSVLEP QRTILLAEKG VDNSFVRADP SFQFLATMNP
GGDFGKRELS PALRNRFTEI WVPPLSDNDD ILCIVLSKLD KEYEPFARVI VDFSQWFGQT
FRTTASTAFS IRDILVWVNF INKSNNGNGP LSVIQGAATV FIDTLGANPS ALIAIDPKSL
DEQRQRCLDK LSDLIGCDAT AVYRAPLHLA IEPTELRIGE YFIKRNANEN FEVGFALNAP
TTKLNAMRVI RALLVEKPIL LEGSPGVGKT TLISALARAC GQPLTRINLS DQTDLMDLFG
TDIPVEGAEA GHFAWRDAPF LRAMQDGEWV LLDEMNLASQ SVLEGLNACL DHRGEVYISE
LDQVFKRHPN FRLFAAQNPH HQGGGRKGLP SSFVNRFIVV YAEVFSDEDL LLIASHNFPG
ISPDIVNQMI RFISNLETRI VVEKAFGSQG SPWEFNLRDT LRWLHLLTSA DPLLSTGAVD
DFLNITIQQR FRSDRDRSEV NKLYAEVFGS LPKDHQLYYD ISASAFQVGL AHTVRNNLLK
PLRPPGIDPV SRLRELESLL ICVKHNIPCI LVGPSGCGKS VLLRQIASQA GKSLVTFPMN
ADIDTMDLIG GFEQSDPLRE VNVALRRLSL ALELSTVGAL PQSVPDVAVD LLYALKSRNQ
QANDLTYVLN LIDRLHAQTS SGSNLELALK EAQDLLQRPT SVADPRFEWL DGVIIRALQM
GEWLVLDNAN LCNASVLDRL NSLLEPEGSL IINEHCEADG EPRIIKPHPD FRIFLTVDPR
YGELSRAMRN RAVEIYVEPR SLIASSWAGK ITDVEADLER YKAMLAAMSH DSANETHLHR
LAIDSLSLDD LRLGPRISRL TNCSIGISSL YGGNLISEQV ASSIRPIAPS QLTSDILYST
RKLCKLSAEQ SSCGITEFLP LHPLQNSPII PLLHESSSPL LFGMAVCYEL SWHLSEAWGA
LELQRSQAVN VQISGLNRLQ RSYIADEVPA VQKDSTARSS RFLVGILQAL ETYVRSELQT
PTWENQNKSV FRDLIHSWKR TFHFLTQPTF EEATFQAHLG HMSTNFNDHL ENVSNTSTRQ
LVTTIGNGLN ECFISGFKLS TGLSMERLWG VLRPIPIQDE RVFEQLVHME GLAVQFDQVK
WKSTAAPTDL AKIMDSFVQA YRLVRLGEAN MDTLFQPLQT EIERMHTRFA NESPLTPPLF
AGEFETIRQL ITIDYICRQD GYLPAVNEVT SLSDTSLVTL LRVNSSTNTS KSLQSIQTLT
QDDRQLPQWG ESLSTKVVRK LNSIGSESLS RLVSLETELP LIGGQISQHS GSITANQSKK
LNEVLWHLML NILSVCDSHL VEIFLAARNS LVTDQILESI WYTGEGLSFR LEIFFPQSVA
HHLDGSSSTI NKHFALTFVS LIAHQTSGFM DDIYLASAWI QFSLALVKLY IPDKVFDPQL
RPLVELRSYD ELFRDLKDQL QALEDYSKFQ TGQTTSLRCD IIKEDILSIG TRPTVAQVTY
RPKTSKLTKI QTEFNNILKV LLGCDLNSIL FQHFIGSDAA TQELQVIYEN ISRVSSRLMH
SFRAYEDIML PTVNILHCLN LGISLGREAK LRSALQKLPS TKLLGLVPFL GGKPGTPIPR
EATSMGTELL QYAAAVRSID GLQGIGHIQQ AIFEVIHDLY GQWTQKLEED KKAEEAKNNL
FRYRGGQEEE EAAEQAAFNE LFPSFHDEEE DLPKPPKINN ARGTAIKLAQ MHRKIFLTPQ
NTQESLKILI NHVINKICQT TDHGLGDRDL LSATLLALEG EATNLTATTT PTDYNFYIDT
NITEARRLVS LVSEIRERFH QLQRVDEIGH LQPLADVVAA CDTIFELSHI DPLAKVISKV
EQLHAFVYEW QFGGWASKTY GALPLYTRLT DMLVSWRRLE LSTWNKLFDM EIAKCNDDAA
SWWFIAYQAI ISATINLSQN TQGFHSYALS LMKELENYFS SAPVGQFTGR LSLLKQLHIQ
LTLLVSEAPE LTVIRDSLRN FIDFYMRYEK PVNDLIRSGR IPIEKQMKDV VLLASWKDTN
IVALRESARK SHQKLFRIVR KFRDVLNQPM KLIIDKELPD VILDEMVVLN KPRSLPSFDL
NAFDECDKNI PDWVDKYRRL ANVQRTVQLM SKLSQLPESA IDAPGIIGDF LSNLNAQIVE
LRKETPSVLN DENKNIVKHL KSRKRKLFAE TLKAVRQMGF PYNLGLDTLA KQGTLSTVLA
STSPLTGSNL TILDGIDHYF YRILDLAPRV RNTAQTHSED LTAAEINRSV GLFEGIMYSI
LRRRTELQAS LNDLAALRES SDLLQSLAKA RNGSKIQVGD IANSYRRSPA WLVEILGVGI
QLVELHGKLG GLDNSKVLDL LGLWKERVVS LSTRLESLPV LPAGLITAEH SQVTKDLDSS
FSELRKCLND SCQERPDLAF LIEQIQHWAI IPGRVSSASD DTRQSIETLT QNIKTLCDSM
LVAIEQFNKT TRNLCGSPDE PSWLLKHDEQ LGISIQTLHM TRIRGNICNV LEICKQIDWD
DQIVRVLGPS LVATVAPIVY QYESICNQFI QLLASSHQII CKLGSTLGKH FNHLASEGFC
TPQEKTEESA GQSENLEGGT GLGDGEGAED ISKDIQPDED LTELAQEKNA DSNRDMEDEK
DAVDMADEDL EGDNNSVDGR DDENGSNSDD DEARDEMDEE RGDVDDLDPT AVDEKMWDGA
DEEEAEKDQK GDKPKGQKKK DEPIAAGEQP EAQDLRPDEG EQTDEGQDEE AGAEMEEDIQ
HHEEPNQQDP NVQDQDTLAL PDDMEIDGND NESLSSIDDD ELDELSNADQ QEKEEKASGD
QENDEEEETE MDAGPIEDGK DDNMDQGPED DSTQVQDDET MEQDQEEVPE EKDETEEASK
SDPNGNNDHV VPSDARGGGQ DQDVDQGEEH DNSQDSTAQR EVGREGEDAL DQDKSEGQKG
SLSQPHDQPM ETDPNDGIET MESNPFKALG NALEKWHRQQ QDIKAAQENK AQQPNEEQDT
KIKEFQHLEN DEAAAEAQAM GTATEEQTQH MDDAMAIDDD EDQPPSNQIL PEDNDANGDK
DADEMDTSKA EEQQSKKDEQ REERDTGVTT HQGTYNRDGI LPPNGVPISE DIEDTIQETS
TQLSSTHLEP GLLLRDYEES MRQWTNFQTK THPLSLSLTS QLRLILTPSQ STKLSGSYRT
GKRLNIKRII PYIASSYKRD KIWMRRAIPT KRSYQILLCV DDSKSMGESS SGELALESLV
MVSRALTMLE VGQIGVLGFG ANAFMAHEFS EPFASHDAGA KVLQQFAFQQ DYTNIQFLIR
RTIDRFRLAR QQSTTRGSED LWQLALILSD GLTPSSEHEN IQVLLREAIE ERIMIVFIIM
DDTTKKKEQS VLKLKKVKFL PNDEIRTEYY LDTFPFQYYL VVHNLEDLPG ALAGLLRTWF
AEVNSQNS
//
