ID A0A1W2TFI6_ROSNE Unreviewed; 1096 AA.
AC A0A1W2TFI6;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=SAMD00023353_2100620 {ECO:0000313|EMBL:GAP86811.2};
OS Rosellinia necatrix (White root-rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Xylariaceae; Rosellinia.
OX NCBI_TaxID=77044 {ECO:0000313|EMBL:GAP86811.2};
RN [1] {ECO:0000313|EMBL:GAP86811.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W97 {ECO:0000313|EMBL:GAP86811.2};
RA Kanematsu S.;
RT "Draft genome sequence of Rosellinia necatrix.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. STE20 subfamily.
CC {ECO:0000256|ARBA:ARBA00008874}.
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DR EMBL; DF977466; GAP86811.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W2TFI6; -.
DR STRING; 77044.A0A1W2TFI6; -.
DR OMA; PRRAMHY; -.
DR OrthoDB; 460351at2759; -.
DR Proteomes; UP000054516; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06614; STKc_PAK; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF35; SERINE_THREONINE-PROTEIN KINASE PAK; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:GAP86811.2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Pheromone response {ECO:0000256|ARBA:ARBA00022507};
KW Reference proteome {ECO:0000313|Proteomes:UP000054516};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000313|EMBL:GAP86811.2}.
FT DOMAIN 476..489
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 816..1067
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..42
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..154
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..401
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 845
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1096 AA; 119770 MW; 032ACC2FE5794E00 CRC64;
MDRDMDNSNP NPNQQHLPHH HFHQQPPPLA PPLLPPLPLP SQEQQPLQEQ EQEQQQQQSS
QRRKLTKKPP SQHHHHQHTH SYSVTGDGRF DAQSLQSKRS SSSLKRAPSA PLQNTTGGGR
SSNASNSPPR YPPPPPPPSS QTLPHQPPPP TAPSLSSNSQ NSSNNSSNYY NTVSTHSSPA
LHPGESFPSV PFAPSYQIAA PASALASNTH TSPPTSPHTT FPAASASAGG ATAASGAGVG
VGSGFGIGIG IGIGVGIDFG TAAPSMSTHH NPNPNNTHNF NYHYQQQQQQ QQQQQQQQQQ
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QPQQQQRLSG SQQIPLRPLR SQASEDFVGA
PFDGDTILSQ FDKAAARAPV PYQAAPQAVR PPPPPPTTSD PRMMSPLLRR SASFSVTNAT
MSEKSLATRI NEVPVITSKR YSDESKESKG SSSLRKKTGF SSLVSNLVGS PKKPVISAPE
NPVHVTHVGY DSSTGQFTGL PKEWQRLINE SGIPENAQRE NPQMIADLVT LYKEITERPH
EDQVLEKFHD VRAPEFRTPS GGTVTSAGIY SPNLAGMSPI TSPPASPRFP IVNNEGTFEN
PRAPPPVPVP GKSPVPHTAR DHPNLQPSRP APKPPISMQT RMQPQPQLQY PAKDSGIGLS
QPGEDLPALA YAPSPKDNGV PMLPEELRSR SNSRANGSSP YNPHAPQGPT SQPSPAMQAA
YQQQLMQQQQ EQAMSQAQAA MKGQLGRSQS TRQAPAQSMG TRTQHPRPPD ANGGGGPGGP
QGQVQPRSRR TRQSNTMDIA AALKRICSEG DPREIYRGFS KIGQGASGGV YTGNERGSNR
LVAIKQMNLE QQPKKDLIIN EILVMKDSIH PNIVNFIDSY LCGGELWVIM EYMEGGSLTD
VVTFNIMTEG QIASVCRETL KGLQHLHSKG VIHRDIKSDN ILLSLEGSIK LTDFGFCAQI
NEAHNKRTTM VGTPYWMAPE VVTRKEYGRK VDIWSLGIMA IEMIEGEPPY LTESPLRALW
LIATNGTPQI KEEHNLSTVF RDFLYFALKV DPEKRASAHD LLRHDFMKLC VDLGSLSPLV
RAAREARQQE KAQKGN
//
