ID   A0A1W2TLJ5_ROSNE        Unreviewed;       853 AA.
AC   A0A1W2TLJ5;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Putative rho-gtpase-activating protein 8 protein {ECO:0000313|EMBL:GAP89176.1};
GN   ORFNames=SAMD00023353_0901650 {ECO:0000313|EMBL:GAP89176.1};
OS   Rosellinia necatrix (White root-rot fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Xylariaceae; Rosellinia.
OX   NCBI_TaxID=77044 {ECO:0000313|EMBL:GAP89176.1};
RN   [1] {ECO:0000313|EMBL:GAP89176.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W97 {ECO:0000313|EMBL:GAP89176.1};
RA   Kanematsu S.;
RT   "Draft genome sequence of Rosellinia necatrix.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DF977454; GAP89176.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W2TLJ5; -.
DR   STRING; 77044.A0A1W2TLJ5; -.
DR   OMA; RKTWIYE; -.
DR   OrthoDB; 1328399at2759; -.
DR   Proteomes; UP000054516; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04399; RhoGAP_fRGD2; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054516};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          2..434
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          213..290
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          468..666
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          337..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          675..853
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        675..689
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        690..710
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        738..784
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        815..842
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   853 AA;  95551 MW;  01E926EC4EE0F236 CRC64;
     MPGFTDSFWT PDYAAGLGVL FTKLQQGVQE NRQILTIARM RAEAEELYGQ RLGDIAPAAD
     KVTGGFSRDD GASVRKAYDG MRTEMEDASR NHRKIAQSIR DLVVNPFARW CDAHESRIQD
     SQDELQARIK AHDRQVEIVK KLRSAYFNKC RLAEDIEEEN KLAFQDPETS PKINKNIPEI
     KVSPQKEEPE DEIYEIGDET YQPEQVKQIL LHMMNTIKMG ETKVPILGTY ANTSCGSDIV
     EYLQRHMGTT SVSYAERIGQ DLVTNGFLRL VGNVGNNFAN SSKLFYQWRP KAFQMSGLPD
     KKAAMSRTFS MPASSDSGSE SPVVGAVSEY LSGWNVLNNQ HPNETQPERM RREARETDEK
     YKAGVKKLDE LRCDLEEAIF MHLRFLERCE LDRLKAIKTV VLDFSGTISN VIPSLQSTVD
     HMILYQETIQ PGGDLRYLLE NYRTGRFAPK VVTYENYYNK VDEQTFGVDL EARARADKKR
     VPVIVTTILT YLDHHYPDLE GDEARRGIWL ADVQLPQVHK LRAKVNDGKP FTSEVLAEFD
     IPTVAHLLKL YLLELPDSLV SSHVYEIIRT IYSTPTTDNT DDARVAVLQQ TLSQLRLTNI
     ATLDACMNHF TRLIDLTSAD EDYVQNVAAT LAPCILRPRV ETSLTMEEKH ACRLIRDLFA
     HKSAIFGELK RMSSLTHSGS VNNSRPRAIS TDESNRRAHM EERQRALLEK AAPRSRATSP
     APGPRHRRDR STGGPETRFP IASPTSTTER HRGSLGLTTR KRQSLEVPDG PSQPPTTEVN
     GGANGDSPKN DGDGIVSKRD SLGRTGARFV GGRRVTQGST PSTPRSGATD ARAGNETPTQ
     DRGVTLVDAP MND
//