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Database: UniProt
Entry: A0A1W4V2Z9_DROFC
LinkDB: A0A1W4V2Z9_DROFC
Original site: A0A1W4V2Z9_DROFC 
ID   A0A1W4V2Z9_DROFC        Unreviewed;      1226 AA.
AC   A0A1W4V2Z9;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   05-JUN-2019, entry version 15.
DE   SubName: Full=disintegrin and metalloproteinase domain-containing protein 12 isoform X7 {ECO:0000313|RefSeq:XP_017050720.1};
GN   Name=LOC108094593 {ECO:0000313|RefSeq:XP_017050720.1};
OS   Drosophila ficusphila (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=30025 {ECO:0000313|Proteomes:UP000192221, ECO:0000313|RefSeq:XP_017050720.1};
RN   [1] {ECO:0000313|RefSeq:XP_017050720.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (APR-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   RefSeq; XP_017050720.1; XM_017195231.1.
DR   SMR; A0A1W4V2Z9; -.
DR   GeneID; 108094593; -.
DR   OrthoDB; 162519at2759; -.
DR   Proteomes; UP000192221; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000192221};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00117091};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Integrin {ECO:0000313|RefSeq:XP_017050720.1};
KW   Membrane {ECO:0000256|SAAS:SAAS01078504, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192221};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01078486,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01078482,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   1226       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010707112.
FT   TRANSMEM    794    818       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      270    473       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      479    566       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   DOMAIN      718    755       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   REGION       82    107       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1W4V2Z9}.
FT   REGION     1071   1136       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1W4V2Z9}.
FT   COMPBIAS     91    106       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A1W4V2Z9}.
FT   COMPBIAS   1094   1129       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1W4V2Z9}.
FT   DISULFID    538    558       {ECO:0000256|PROSITE-ProRule:PRU00068}.
FT   DISULFID    745    754       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   1226 AA;  134569 MW;  4ED1CDF3774D5EDB CRC64;
     MWIQIAYLIL IIAQLCALVT SAGEADYTLD DSFWNEESPV GEVERLLKEY RQNQELVRRI
     GGHYYQIIYP VQLRHHEKMG ISTREVSPPK PGQRPRPHDD SGFNRGRTKK HFHRTSLLIK
     AFNHKFRLDL ELNSQLLSPN VQQKHYHVGG YLVDGNRHDI EHCYYHGTVK DYPGASAAFH
     TCNGVSGVIH IGNETFVIHP FYGGDLSKHP HVIFEARTKA NKGCANSGNL DSWRLSRRTK
     HLSAGVAGVV EEILQTGAGR NKRDVREATK YIETAIIVDK AMFDKRNGST RAEVVHDAIQ
     VANIADLYFR TLNTRVSVVY IETWGKNQAV IDGSKDISKA ISSFNDYTSR NLFQIERDTT
     QLLTGETFAG GEAGMAVPET VCTPRAVGIS VDVNVYEPHL LAGTMAHMIG HNIGMGHDDG
     REECFCRDWH GCIMAQSIVG QENVQPYKFS ECSKKDYIDA LRTGHGLCLL NKPNEIELRR
     NCGNKVVEED EECDCGTFED CALDPCCDGI TCKLKSEAQC ASGACCDQCR LRPKDYICRD
     SNNECDLPEY CDGEIGQCPS DVFKKNGSPC GLSKSGISGY CFQGYCPTLS LQCEAIWGYG
     GSAADRQCYE QFNSKGSING HCGRDANEHY IKCDPENVQC GTLQCKEGER QPVNDGIDQL
     YSRTIISIKG QEYECKATSG QVGSNSYPEH GLVKDGTPCG DNLICLNQTC VSLFPHVDQT
     KCPANSQGQE CSEHGVCTNT NRCFCDMGWG GQDCSSVVLL TTAQPTEAPS TPENTIKMEK
     KETPYENYHG SNTVFLVGVL MSVVGFVFIT FTLMALCYRS VVVHRNFSLC LRRKTTTLKY
     DPPYSKKPIA KTYGGAATAP NHHSVEEVSL DGSSKLVYAN QTGFRDKGIH GRRYTTCGED
     DQSHAEKGIL KKHGYGLVHG EQLKDKWGDD NQSDNLELIT QDGTLASTSG GAAASEVERT
     LKSLNGYHED ILEALRNAAT HRGTGTGNTP VGSGSLSEEM LRKTLQDCSS SQLGYAAEQY
     KRNIGSKSSS RENICDNAAV HAIILDGGGL GLASSVGGGG LGGLGGGGGG STSISGGIPH
     GSSMLHHHRS QHQLHQPSSV GLQSVGQQQQ QQQQQQQQQQ QQQQLDDDDA PSTGPLRIRN
     LEDLIRQLEH HSSRHMSPSG SEDIRMSETE ADRHYRLESS AACSESSQGL QAGIPCVIKL
     QSANTTISEN RYNSCVLQQK LSSPFR
//
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