UniProt: A0A1W4W338

Database: UniProt
Entry: A0A1W4W338_AGRPL

LinkDB:  A0A1W4W338_AGRPL 
Original site:  A0A1W4W338_AGRPL

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
Protein domain (6)   
   InterPro (4)   
   Pfam (2)   
All databases (16)   

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ID   A0A1W4W338_AGRPL        Unreviewed;       513 AA.
AC   A0A1W4W338;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Fatty acyl-CoA reductase {ECO:0000256|RuleBase:RU363097};
DE            EC=1.2.1.84 {ECO:0000256|RuleBase:RU363097};
GN   Name=LOC108732337 {ECO:0000313|RefSeq:XP_018318580.1,
GN   ECO:0000313|RefSeq:XP_018318581.1, ECO:0000313|RefSeq:XP_018318582.1};
OS   Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC   Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX   NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018318581.1};
RN   [1] {ECO:0000313|RefSeq:XP_018318580.1, ECO:0000313|RefSeq:XP_018318581.1}
RP   IDENTIFICATION.
RC   TISSUE=Entire body {ECO:0000313|RefSeq:XP_018318580.1,
RC   ECO:0000313|RefSeq:XP_018318581.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
CC       {ECO:0000256|RuleBase:RU363097}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain
CC         primary fatty alcohol + CoA + 2 NADP(+); Xref=Rhea:RHEA:52716,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:77396, ChEBI:CHEBI:83139; EC=1.2.1.84;
CC         Evidence={ECO:0000256|RuleBase:RU363097};
CC   -!- SIMILARITY: Belongs to the fatty acyl-CoA reductase family.
CC       {ECO:0000256|ARBA:ARBA00005928, ECO:0000256|RuleBase:RU363097}.
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DR   RefSeq; XP_018318580.1; XM_018463078.2.
DR   RefSeq; XP_018318581.1; XM_018463079.1.
DR   RefSeq; XP_018318582.1; XM_018463080.2.
DR   STRING; 224129.A0A1W4W338; -.
DR   EnsemblMetazoa; XM_018463078.2; XP_018318580.1; LOC108732337.
DR   EnsemblMetazoa; XM_018463079.1; XP_018318581.1; LOC108732337.
DR   EnsemblMetazoa; XM_018463080.2; XP_018318582.1; LOC108732337.
DR   GeneID; 108732337; -.
DR   KEGG; apln:108732337; -.
DR   OrthoDB; 1434498at2759; -.
DR   Proteomes; UP000192223; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0102965; F:alcohol-forming long-chain fatty acyl-CoA reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0080019; F:alcohol-forming very long-chain fatty acyl-CoA reductase activity; IEA:InterPro.
DR   GO; GO:1901568; P:fatty acid derivative metabolic process; IEA:UniProt.
DR   CDD; cd05236; FAR-N_SDR_e; 1.
DR   CDD; cd09071; FAR_C; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR026055; FAR.
DR   InterPro; IPR033640; FAR_C.
DR   InterPro; IPR013120; Far_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11011:SF60; FATTY ACYL-COA REDUCTASE-RELATED; 1.
DR   PANTHER; PTHR11011; MALE STERILITY PROTEIN 2-RELATED; 1.
DR   Pfam; PF07993; NAD_binding_4; 1.
DR   Pfam; PF03015; Sterile; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516,
KW   ECO:0000256|RuleBase:RU363097};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW   ECO:0000256|RuleBase:RU363097}; Membrane {ECO:0000256|RuleBase:RU363097};
KW   NADP {ECO:0000256|RuleBase:RU363097};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU363097};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW   Transmembrane {ECO:0000256|RuleBase:RU363097};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363097}.
FT   TRANSMEM        373..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363097"
FT   TRANSMEM        491..512
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363097"
FT   DOMAIN          26..295
FT                   /note="Thioester reductase (TE)"
FT                   /evidence="ECO:0000259|Pfam:PF07993"
FT   DOMAIN          378..468
FT                   /note="Fatty acyl-CoA reductase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03015"
SQ   SEQUENCE   513 AA;  58799 MW;  372E72CA9ADDA779 CRC64;
     MTDLIENISV EATPIQKFYA GANIFVTGAT GFLGRILVEK LLRSCPDVAS IYILIRNKKG
     KTAHDRLDEM FDDVVFKRLK DEQPKFRHKV VAVAGDCCLP DLGMSMQDRQ MLINEINIVF
     HVAATVRFDE KLKVAVAINV RSVQDVLKMS KEMLNLKAVV HVSTAFAYCH LNSIEERFYP
     PPMSYKKLLT FVDVSTETLL EKITPEVLDK WPNTYTYTKA VGEDVVNCEG VGLPVAVFRP
     SIVISTYKEP IKAWINNMYG PTGVVMGAGI GLLHSLHCNP KVNANIVPVD MCVNALIASA
     WETNKNFEES QKLNKQPPSP PVPIYHFESS NENPIAWGSF MDKCSKYGMR TPTVKAVWYY
     YLSLQTTLIG HNLLILFMHF LPAFLCDMAL TLFGKQPRLI KVYKKIHKFC AVISYFSTRS
     FEFGSKRVRS MIRNMTEQDQ KIFFCDLRKL DWDEFFLEYT EGIRVYLIGD PIETLEAAKI
     RWRKLYYLHQ GLKLLLLFFV VRILWAVLKI IFF
//

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