ID A0A1W4WA04_AGRPL Unreviewed; 979 AA.
AC A0A1W4WA04;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Glutamate receptor ionotropic, kainate 2-like isoform X4 {ECO:0000313|RefSeq:XP_018320854.1};
GN Name=LOC108733787 {ECO:0000313|RefSeq:XP_018320854.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018320854.1};
RN [1] {ECO:0000313|RefSeq:XP_018320854.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018320854.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR RefSeq; XP_018320854.1; XM_018465352.2.
DR AlphaFoldDB; A0A1W4WA04; -.
DR EnsemblMetazoa; XM_018465352.2; XP_018320854.1; LOC108733787.
DR GeneID; 108733787; -.
DR OrthoDB; 1011589at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF598; EYE-ENRICHED KAINATE RECEPTOR, ISOFORM B; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_018320854.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..979
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010715410"
FT TRANSMEM 541..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 803..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 411..779
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 421..485
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 954..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..970
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 979 AA; 110727 MW; EF0F07873FA7DAB3 CRC64;
MQFGICWAIF GFAHTILAAL ALPPIIKIGA IFTEEERNGS VEIAFKYAVH KINKDRSLLP
KTNLVYDIQY VKKDDSFHAC KKACSQVRMG VHAVFGPSDP LLASHIHSIC DALDIPHLEV
RLDPEADSRE FSINLYPAQK LLNLAFQDIM SFLNWTRFAI IYEEDFGLIK LRELVKSSQS
SKIEVYLRQA DVTSYRRVLK EIKSKEINNF IVDTKPENLQ DFLKGILQLQ MNDYKYHYLF
TTFDLETFDL EDFKYNFVNM TAFRIIDTKD LTVQEILRDM ARFQPHHLRP SSLNSSFVKT
EAALIYDSVF VFAVGLQTLD QSHTLRIQNA SCDREEPWDG GLSLINYINS VEMKGLSGPI
ELKESQRVQF TLDLLKLKHH SVKKVGEWRP STGLNITDRA AFFDTGTTNV TLVVTTILEP
PYVMMHHEQN YTGNGRFYGF CMDVLELVSK EVGFEYLLEL VPDKKYGAQD PETGNWNGMV
AQLILHKADL AVGSMTINYA RESVIDFTKP FMNLGISILF KVPSSQQARL FSFMNPLAMD
IWLYVLSAYL LVSVTMFVVA RFSPHEWHNP HPCQTDNDII ENQFSLPNSF WFTIGTLMQQ
GSDLNPKATS TRIVGGIWWF FTLIMISSYT ANLAAFLTVE RMITPIENAE DLASQTEITY
GTLESGSTMT FFRDSMIETY KKMWRFMENK KPSVFVPTYE EGIKRVLEGN YAFLMESTML
DYIVQRNCNL TQIGGLLDSK GYGIATPMGS PWRDKISLAI LDLQEKGEIQ MLYDKWWKNT
GETCSRDDKG KESKANSLGV DNIGGVFVVL LCGLAFAVIV AICEFCYNSR KGNGYSKRNM
ALLPQQSLCT EMASELCFAM RCRASRQRPA LRRQCSKCLA KIANHDATGV GDGAGGGVAT
NPILPPPSAP RSSAKVPAPA TSLVLLPHQF NFSPILGNEN RQCFEDLKER LQKPETIKVN
SSTNTVEPPP KTKRETLVN
//