ID A0A1W4WAL0_AGRPL Unreviewed; 2240 AA.
AC A0A1W4WAL0;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Uncharacterized protein LOC108734135 {ECO:0000313|RefSeq:XP_018321049.1};
GN Name=LOC108734135 {ECO:0000313|RefSeq:XP_018321049.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018321049.1};
RN [1] {ECO:0000313|RefSeq:XP_018321049.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018321049.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR RefSeq; XP_018321049.1; XM_018465547.1.
DR STRING; 224129.A0A1W4WAL0; -.
DR EnsemblMetazoa; XM_018465547.1; XP_018321049.1; LOC108734135.
DR GeneID; 108734135; -.
DR KEGG; apln:108734135; -.
DR InParanoid; A0A1W4WAL0; -.
DR OrthoDB; 3090466at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00112; LDLa; 5.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR PANTHER; PTHR24270:SF66; CUB AND LDLA DOMAIN, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR Pfam; PF00057; Ldl_recept_a; 5.
DR Pfam; PF01390; SEA; 1.
DR Pfam; PF15494; SRCR_2; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 5.
DR SMART; SM00202; SR; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF82671; SEA domain; 1.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 5.
DR PROSITE; PS50024; SEA; 1.
DR PROSITE; PS50287; SRCR_2; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 380..505
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 1872..1921
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 1970..2229
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1227..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1374..1399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1466..1494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..375
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..711
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1477..1491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1701..1716
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1727..1745
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1739..1754
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1779..1794
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1819..1834
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1856..1871
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 2240 AA; 248889 MW; 05729A71AD5AE22F CRC64;
MDADSSYGGS DTAHDGTLGQ DSNSMDTSHS NPSHDPTNTN SRSSPDSSNY YKNEISLPVN
CDEGDFQKNG KTPTLPQYLS TANFNIDATL ENHNNLEELN KKYRSSQRLN ETPKSSKKDK
AGLDNPAYLD DENVKVNNDD TMGYRNGNLN SSPKLGHEDE PQAEAVNLEL INLKPNGKDV
TGPYENGKGI SGIPVKKDNF ESGTPYDEYF VPVNEHRKYM SYFPFDTTTR NKGRNSVTFA
ETTVSSTTGV DDFGLSVTTP ERGIVEYPDW LNVQENSRYQ HSFISPLIGS GFSTYFKTDS
NVLVLVGIIG NPEAHPIEEG RHFGGSSSTD SIKTAGGLFG SNSDGRTMEA EKAPITPSPP
SSTVPSLPPT TPKPLSEVTV PRTIQSQFKI DNLQYEPELG NKNSSEFKEL AEAIEEELKS
ILFSRDVLNY GSAEIQLKVL EFSPGSVVVK FRVGWVMKDG VHNAKDPIDR DALEKKLRDA
LAYNHGYIAN YRIADDSVTV ETVIDLCKTN NNNGCEYNCS FSYKIEDFIC ECPEGEYIQE
DGKKCGQQHH LTTEHIDHNH GFEHSNEGDD KEHEQVAATF ETSSVPHTEK EVKAETTVSP
ATQPYATSSH EPEGVSEEHE HQEEHEQHEH VTPIITLIST QTHTTIQEPV QETSAHEDDN
IQEEYHPLQL PVTTTTTTET PVTYGNVNEV IPLSTEKDLK EEEEQSTEIK DVNEPEQATT
GLVDSHSHSE EDTGLQTSVH VITTTAQSIS ETTTHSQSPM YWENETNQPI QETSLPSRTE
SVNEHQEEEE QEEENTSTHV LYTTSTPIHE ESEEEEEKHV ATEVHLPVAN ESYSSERTEP
ANVSHALEET ESAVETTTEP RIQTPKPFET EESEHGNNET SVSHATSFEQ ITTASSVAES
VTVNPTTTEN LISIHSSLPH QLIENYTTTS PVVTVSESVS VTNTYNEMDN ASDSDRQPKF
DITLGHTPVE PEMEYHTHDH EDEDERETIP FMHQEVQLVT TDRIKTEEAT ISSVEEQSSH
TENSSLPFGL VHKEENNSMM AINETDGVLT TTFTPYTSEE SLFVHHTSPP SFLESSEEED
ETQSTLMEDS NESSSTALSA SSEEMKVEPT QTTTSSEMEL TSFQETSTST EYTFSGRSFE
SNHPALFAND HNNVTYLEDN STMSKQININ ETLHRPLSTF ENDNLNGEDE RQEFTTSTVA
PRLDNDEKNV TNPLDPNVTD VALGVLPLEE DKSGRSQNSS RSTDNTEINT TTNTNETENT
SVPEMIADDH NTISSTTYSI AAVENSTQES TNNTSPTEKP LNDTDIEVHK WEDTTTTVSN
VSEEYNQKNE SSTVSFENLT TENDINDEEQ STSLSLFNAV EPITLKYEQS TNLSSNENAV
NESAAEPSHL METSNGTNEN NDTTISQLES YVNGTNEIHT NNATSNSDED LIAMETTTTS
LQKPKMFSNV PVEESTMNNN ETVANYSSIS EAPDSSKTIP EPKENETSTE SHSFGDDMLI
TTASHNETSH LYEVHEVTDD ITTPTPTRTF NYSPLPVIPL TDSEPIENEK INIESDNLYS
SNLNDISDEK EKYSSKYYYS DKKKEFSKTV DAPTTESIQG SNNTDQEEDH LIATDFVSHI
TITDKPNNAT IAPINNLSST QTTNTIIEST EPVYNVTSEV KPVVEGYTLS SFSRCSAGQF
QCVNGTSTKG GSYCVSNSDR CDSVKDCTDG SDEVGCDQEN CKDNFQCKSG QCLKRHLVCD
GIFNCDDNSD EENCESWKCN FDELSCGDGK RCIPLSWKCD GKSHCFDGRD EQNCHSQPCE
SNHFYCSEQD SCIPASWRCD GVDDCKSGED EKLCECGIDQ FKCQTGGGCI QAENRCDGIE
QCPDLSDEWN CLRLRETNDT SSYLEALVSN NSWQPICADF WNTTYSDLAC QSMGYAKATS
TNYKLLEKSS SGSQFLKLNP SERYGASLSA QLIKTDSCDN VVTLTCQENV CGNNNGLDTS
SFGSKNENGN EKGWPSIALL FNRRYQIQCT ANIVTPNWVI ASYACLYSVS GQPPSSNPYD
WELLAGGNHF FDSSAENSSI QSLSVKNIIP YPQAKYSQFI YRNNIALVQL MKPLDFEKNI
SAVCLPPQNE EPNQYCITVG WSMKKPGESS LKEYLRYLPD LNQNKRDCNS SDHYNGRFTT
DLLCVDHLTT DEPCEDDQGA PLMCFSESSQ NWELRGLLSL DGNCQKFHRP SLFTSTSGEI
GTWIENTIGT KPKPFNNKLQ
//
