ID A0A1W4WDE6_AGRPL Unreviewed; 1441 AA.
AC A0A1W4WDE6;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Mediator of DNA damage checkpoint protein 1 {ECO:0000256|ARBA:ARBA00015014};
GN Name=LOC108734791 {ECO:0000313|RefSeq:XP_018321969.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018321969.1};
RN [1] {ECO:0000313|RefSeq:XP_018321969.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018321969.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
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DR RefSeq; XP_018321969.1; XM_018466467.2.
DR STRING; 224129.A0A1W4WDE6; -.
DR EnsemblMetazoa; XM_018466467.2; XP_018321969.1; LOC108734791.
DR GeneID; 108734791; -.
DR KEGG; apln:108734791; -.
DR InParanoid; A0A1W4WDE6; -.
DR OrthoDB; 19990at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR CDD; cd17744; BRCT_MDC1_rpt1; 1.
DR CDD; cd18432; BRCT_PAXIP1_rpt6_like; 1.
DR CDD; cd00060; FHA; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR23196:SF1; MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1; 1.
DR PANTHER; PTHR23196; PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF00498; FHA; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223}.
FT DOMAIN 25..75
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1263..1329
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 235..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1441 AA; 161476 MW; 07DE0F2208481459 CRC64;
MTEGRERVGY LRVSGHNYPV FKGLNIIGRN KLATVIMKSP TISHQHSMII VVEKGKYFLS
DLNSANGTFL NEEKLTPLLL YEIPNMCKMK FARISAIFIE CPGRIGSSTF RREQFSQATQ
NTENLFMTAT QKLDVIEEVS IHDLATQPID DLIIRTMNTT EKTNITKTQL SNEIHELPTQ
ILCPDVAMEV SVQDVQIQVN TTLTNQTNLE EDMVNVISDE CIDDSVLPTI SFHNTSDLNK
SNNYTQNKQV NDHVPSKIKN TSSQTASYDS DYKKKLNKSN STTIDEIESN RNIPTDANNL
QHKVESKTEH LEKGSQTPNV SQGNSSQSQI HVSQIKRKVR KRISSDSDTP SSLDILSNPA
SPVPQLKTKK RNPLSSDESG GDSGTGVVLP NKVGPRKKLV KRRISSENSS SDTDIERLSP
NKILSKKIKS RAVSRKLESN SDTDIEKEPG NRHKVAHNKE NSNIKTTMNQ SQNTINSQCM
ENSFKLALSN TMDALNTDSE SDYVFGNPTQ NVSGSQTDSS KQMKTNVENP SDTEMLEEDI
DIFMQPTQRS VLPKSTKNAT VEDSNKRSKK MNRNDDSGSE TDDDLLAQKS QEINNSKTTK
KSNSQNQTTN EPCETENVKV RTNCLNEKSK IHENEESSVS SLQNFNIAKE IQKLKNMDNI
FLASIRDLKN AEAALNDEHK FQSQKQSQSV KDAKTQAKVI DLCDNEDDIF LQPTQKFAAS
TSVTINTFGS KIPSQDDEDD IYLEPTQKFK IPYKNQPYKN ELTQNEDDDV YLQPTQKFAT
SCIPMNDKLF NRKESQNEDD AIFLQPTQKL QNKESSQDEE DDDIYLQPTQ KFSLPLPAII
ESSDANEFSQ NENDLQPTQK FLAPRKSKLG YLECSENDNY GNDVCLQSSQ KLSVPSKSEN
DVSSDIPKRC AENSKASLPS VESQLEVMFS SQNISADNDR PSNPLANVLD EEQSQTNEEQ
NSEEIKQTSS YSKRSDVNTD EKENLSSVEK LRQKSVIDRK TASLQTIDDR TDAATASEIR
NFVDRGVGNL QTRQPELNVY SATVASISPS QRLRRRASSN RSVSVPVAKL SSKTKGPSCV
EVSLENKRTI LKPHSLTVCD ALTSGKRTRK TALVKDDDSD NQADIKDELI EKRVTRRTTS
EYTIARKKKS MHLDSFKPNT SIPVSEIADE DFLNMPKSSS SRRTEKSEAS TSKRAPETLS
PPVTPQKRKK TVKVSPANDS MLFSTSNQSK FEKSNVESRL MDITPERRNQ RTKVVFTMLD
SPQLSLIVRQ CGGIVVDTVE AATVLVTTSI KRTQKLLTAV GLGKPVCSVK WLEDSKVARN
FLDPWDYILT DDEAQQKWNF SLMESLNRSN KKKLLEEYVF QLCVTTATDV LKSAIEACGG
KCISRAPAKT DKKFIVVSSP DNRNKYKKFL QKVPPVPVVT PEAIFHGVLV QKFEVAPFLL
S
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