ID A0A1W4WE02_AGRPL Unreviewed; 416 AA.
AC A0A1W4WE02;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Hydroxysteroid dehydrogenase-like protein 2 {ECO:0000256|ARBA:ARBA00040243};
GN Name=LOC108734926 {ECO:0000313|RefSeq:XP_018322196.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018322196.1};
RN [1] {ECO:0000313|RefSeq:XP_018322196.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018322196.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Has apparently no steroid dehydrogenase activity.
CC {ECO:0000256|ARBA:ARBA00037788}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR RefSeq; XP_018322196.1; XM_018466694.2.
DR AlphaFoldDB; A0A1W4WE02; -.
DR STRING; 224129.A0A1W4WE02; -.
DR EnsemblMetazoa; XM_018466694.2; XP_018322196.1; LOC108734926.
DR GeneID; 108734926; -.
DR KEGG; apln:108734926; -.
DR InParanoid; A0A1W4WE02; -.
DR OrthoDB; 4594at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd09762; HSDL2_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR42808; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR42808:SF3; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF02036; SCP2; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223}.
FT DOMAIN 318..409
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
SQ SEQUENCE 416 AA; 45676 MW; EC75BA6F9F229FE0 CRC64;
MNTGKLKGLT IFITGASRGI GKSIALKAAK DGANIVIAAK TATPHPKLPG TIYTACEEVE
KLGGKGLACI LDVRDEAQVQ AAVNETVNKF GGIDILVNNA SAISLTNTSD TDMKRYDLMH
GVNTRGTFLV SKTCLPYLKK SPHAHILNIS PPLNMQAHWF ANHVAYTMAK YGMSLCVLGM
HEEFRPSKIG VNALWPRTAI HTAAIEMLSG KDSANYCRKP EIMADAAYYI LCQDPKTTTG
NFFIDDEVLQ KAGVNDFDQY CVNPEYRDKL MLDFFLDATP VSEFKEQIKE IQKKPKESNT
STSSSGQVAN LFKSIENNLN PQLVEKVQAV YQFEVTGEDA GKWFIDLKSG DGKCGQGEAP
DKPDATLRMD SKYFFEIFSG KQKPAMAFMT GKLKITGNLQ KAMKLEKLMG SLKAKL
//
