ID A0A1W4WEU7_AGRPL Unreviewed; 565 AA.
AC A0A1W4WEU7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=E3 ubiquitin-protein ligase CHFR {ECO:0000256|ARBA:ARBA00017908};
GN Name=LOC108732370 {ECO:0000313|RefSeq:XP_018318638.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018318638.1};
RN [1] {ECO:0000313|RefSeq:XP_018318638.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018318638.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CHFR family.
CC {ECO:0000256|ARBA:ARBA00005797}.
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DR RefSeq; XP_018318638.1; XM_018463136.1.
DR AlphaFoldDB; A0A1W4WEU7; -.
DR STRING; 224129.A0A1W4WEU7; -.
DR EnsemblMetazoa; XM_018463136.1; XP_018318638.1; LOC108732370.
DR GeneID; 108732370; -.
DR KEGG; apln:108732370; -.
DR InParanoid; A0A1W4WEU7; -.
DR OrthoDB; 337585at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:UniProt.
DR GO; GO:0051716; P:cellular response to stimulus; IEA:UniProt.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR CDD; cd00060; FHA; 1.
DR CDD; cd16535; RING-HC_RNF8; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR15067; E3 UBIQUITIN-PROTEIN LIGASE RNF8; 1.
DR PANTHER; PTHR15067:SF8; E3 UBIQUITIN-PROTEIN LIGASE RNF8; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 26..74
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 391..429
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 274..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 62692 MW; 11710407F72F7C5E CRC64;
MEKAILTNYG TSKAFSTPIV LSNEKYGLGR GLQNDCVFDD VSISRNHCTI EKSGKEWIVI
DRSSNGTLVN GILVGRLKAH VLQNGDVVTL GSNTQFQFIK RNSAPEPVTE SNKSSLSEEE
IINITDATLT KVEQPNLRLS PSLEDEFNIP MDVEGNSNID KHITNENNSS VKSGTVNESN
HKSQLPHCIE HKVNMTSTSD VPKTTLISIN PTSYKGFFSS FVINSNVNKK SITLPSISQP
SFAQNTLPGA TATTSTAIPS WLIGVVSQKV NQQSQKSKCS ITKSPKSARL KSSITSPPKT
YSNTKKGSKK KSTEANDQPS CSKDFPQAKV ESRNAEGIKE NIPKDLPQAK DELKNVNDIK
EKITKEDTEP KPGCSKSSET KLHAVQDELQ CIICTEMFIK AVTLSCSHTF CKFCIDEWKK
KKTACPICRA PICSILPTLV IDSFIEKILE NADEETKLQR SKLIADRESQ QASGSKDYRG
KEKSATDVFD EAFAHDAIIL SSDSDMNSYD SDAETMSYYD DDSDNGRILR MQRLRNNFVD
RVKEHLERSL YNQIQLISIL NDTLY
//
