ID   A0A1W4WF15_AGRPL        Unreviewed;       977 AA.
AC   A0A1W4WF15;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Vacuolar protein sorting-associated protein 18 homolog {ECO:0000256|ARBA:ARBA00017338};
GN   Name=LOC108732640 {ECO:0000313|RefSeq:XP_018319047.1};
OS   Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC   Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX   NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018319047.1};
RN   [1] {ECO:0000313|RefSeq:XP_018319047.1}
RP   IDENTIFICATION.
RC   TISSUE=Entire body {ECO:0000313|RefSeq:XP_018319047.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004492}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}.
CC   -!- SIMILARITY: Belongs to the VPS18 family.
CC       {ECO:0000256|ARBA:ARBA00010454}.
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DR   RefSeq; XP_018319047.1; XM_018463545.1.
DR   AlphaFoldDB; A0A1W4WF15; -.
DR   EnsemblMetazoa; XM_018463545.1; XP_018319047.1; LOC108732640.
DR   GeneID; 108732640; -.
DR   OrthoDB; 22879at2759; -.
DR   Proteomes; UP000192223; Unplaced.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR   InterPro; IPR007810; Pep3_Vps18.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR   PANTHER; PTHR23323:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR   Pfam; PF00637; Clathrin; 1.
DR   Pfam; PF05131; Pep3_Vps18; 1.
DR   SMART; SM00299; CLH; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50236; CHCR; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          38..445
FT                   /note="Pep3/Vps18/deep orange beta-propeller"
FT                   /evidence="ECO:0000259|Pfam:PF05131"
FT   COILED          811..845
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   977 AA;  112552 MW;  D2E97ED9A182CFD2 CRC64;
     MTSMFDQFEQ ASQKLDSNND LTDISSGYIN MKMEKELPIF TKSKMCFNPS AKITHVAISN
     KNLAVAMANG MLFRMNIHQP EQQNEISLHK YTALCPLTNL FLDPSGNHLL ISFGSKSPEL
     LYLSRKSVKL KVSTKFKGHE ITEVAWNNLN ESESTTGPIL LGTSKGLIFE TEIALDGDKF
     LTSGFSSSIE QYWRQVFDIG KGTDTPITGL HFDRITGTDK YFIFVATPNK LYFFARNINC
     EEKPLLQQVF NKYLNIPEKD TFYKVESKLR YSRLRFWSEN LTVPDSLAWM TEGEILYSKF
     DLPTQENINS ILANAETILF PKPLYQDYSV SQKPPIACVL TEFHVLLAYT DAIKGISLLN
     RDVVYEDNYN EAFGKLINII KDPMTGTIWA VTENAVFRFK ITKEERNIWQ IYCEKQQFDL
     AKKYSRQNPV HYDQVLKKEA DMLFEKKVYE ASAQRYAETQ TSFEEVCLKF IQVDQKNALK
     IFLKKKMERL SPQDKTQITL IVIWVVELYL DQLEEMRITG KEQTATYFDL QKEFQAFLAL
     PQVSDCIKNN KSTIYDLMAS HGDKTNLIQL TIVNKDFEKL IRQHIYKNNF HEALDVLKSQ
     NNRELFYQFA PILMQEIPKF TVKALIDKGA HLSPVKLLPA LVSCDSEEHS REIVKYLEFC
     VGKLKCSEKA IHNLLLTLFA KYDPQKLMEY LNSQGQDIGM VNYDVHFALR LCTEKKLTAA
     CVQLSGLLGL WETAVDQALT INVELAKQIA NMPSQEDEEL RKKLWLKIAQ HVVSGKDNIE
     QAMEFIQQCE LLKIEDILPF FSDFVTIDHF RDAICKSLKD YNQQIQALKD EMREATQSSE
     LVRKEIQSFR NSFTYVSSSD VCEVCNLTLM IRPFYLFPCR HKFHNDCLLK ELNPMLGPIK
     KNKLADLHRQ LNAVGTLSAQ SDNISTCSGL STREAIKADI DSIVASECLY CGENMIRNID
     MPFIDESDYE KIMKDWE
//