ID A0A1W4WFC9_AGRPL Unreviewed; 455 AA.
AC A0A1W4WFC9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Beta-chimaerin isoform X1 {ECO:0000313|RefSeq:XP_018318710.1};
GN Name=LOC108732417 {ECO:0000313|RefSeq:XP_018318710.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018318710.1};
RN [1] {ECO:0000313|RefSeq:XP_018318710.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018318710.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_018318710.1; XM_018463208.2.
DR AlphaFoldDB; A0A1W4WFC9; -.
DR STRING; 224129.A0A1W4WFC9; -.
DR EnsemblMetazoa; XM_018463208.2; XP_018318710.1; LOC108732417.
DR GeneID; 108732417; -.
DR KEGG; apln:108732417; -.
DR InParanoid; A0A1W4WFC9; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20806; C1_CHN; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR46075; CHIMERIN FAMILY MEMBER; 1.
DR PANTHER; PTHR46075:SF2; RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 47..111
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 194..244
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 257..447
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 455 AA; 51516 MW; A3397A6A4F7125A1 CRC64;
MECLYNQLYP PACFFVKLYR MQLDAPVPIP IICNEAPPDL PNYFGRDYHG NISHIEANNL
LSCRPNGAYL VRKSKSANGE FHTLSLKFND KIHHYKLFYD KSGIYVREKR YDCVRSLVAD
GLVTMYLELK APSFLQKLPS ANYHESPYMT LNKKKLQTLT RERSKLIRNN SFLNAISNIE
NQQLTTNGEK YEKNHVFKIT TFKGLNWCEM CGNFLWGFTA QGVKCDDCGI IAHGRCSEKF
PNDCIPDIKY LRGVFGIELT TLLTAHNAKL PFVVTKCVSE VEARGLTVEG IYRLSGFAEE
IEAIKLGFDT DGEKADLSQD KYPNVNVITG ALKLYLRLLP IPLITFLVHP MLIDAMQQKS
FEKRLSSVKQ ALLSLPKPHY CTLHFMMDHL NRVSLHAAIN KMNPHNLATV FAPTLIGPPE
SGSLMLPDMT TDILLIETLI LHCEKIFGTI SIAAL
//
