ID A0A1W4WGI4_AGRPL Unreviewed; 283 AA.
AC A0A1W4WGI4;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=SPRY domain-containing SOCS box protein 3 {ECO:0000256|ARBA:ARBA00014684};
GN Name=LOC108733044 {ECO:0000313|RefSeq:XP_018319572.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018319572.1};
RN [1] {ECO:0000313|RefSeq:XP_018319572.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018319572.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be a substrate recognition component of a SCF-like ECS
CC (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase
CC complex which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000256|ARBA:ARBA00004094}.
CC -!- SIMILARITY: Belongs to the SPSB family.
CC {ECO:0000256|ARBA:ARBA00010910}.
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DR RefSeq; XP_018319572.1; XM_018464070.1.
DR AlphaFoldDB; A0A1W4WGI4; -.
DR STRING; 224129.A0A1W4WGI4; -.
DR EnsemblMetazoa; XM_018464070.1; XP_018319572.1; LOC108733044.
DR GeneID; 108733044; -.
DR KEGG; apln:108733044; -.
DR InParanoid; A0A1W4WGI4; -.
DR OrthoDB; 4057255at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd12876; SPRY_SOCS3; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035754; SPRY_SPSB3.
DR PANTHER; PTHR12245; SPRY DOMAIN CONTAINING SOCS BOX PROTEIN; 1.
DR PANTHER; PTHR12245:SF12; SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000192223}.
FT DOMAIN 25..227
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 229..267
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 283 AA; 32570 MW; 930BCAE8BE44826A CRC64;
MATIQQTRRN MHELPIDRLP IVNCWEGPSE WELDSSDMNT ESTERPLRHG CDDLWSWSLW
EKSPEVKLYG SYLRIAHFHP NWSNGTAGVM GTRILNNGRY FWELEISRRL FGTSMMMGIG
TKKTRLHAGG FINILGEDNN SWGLSHKGLL WHGGRSYFYT KPFRENRRTI IGVLFDGIAG
TLTYYKDGKC LGVAFRGLNE IEEPLYPAVS STAAKTEMSL VTMKRDFVNL QDRCRDVIVK
RIKDKKHLKQ LYVPPKIRHY LSESILEESQ SLQLVIENGL STV
//
