ID A0A1W4WHJ9_AGRPL Unreviewed; 1125 AA.
AC A0A1W4WHJ9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Regulating synaptic membrane exocytosis protein 2 isoform X6 {ECO:0000313|RefSeq:XP_018323421.1};
GN Name=LOC108735773 {ECO:0000313|RefSeq:XP_018323421.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018323421.1};
RN [1] {ECO:0000313|RefSeq:XP_018323421.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018323421.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_018323421.1; XM_018467919.2.
DR AlphaFoldDB; A0A1W4WHJ9; -.
DR EnsemblMetazoa; XM_018467919.2; XP_018323421.1; LOC108735773.
DR GeneID; 108735773; -.
DR OrthoDB; 2891597at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd04028; C2B_RIM1alpha; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR039032; Rim-like.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12157:SF21; RAB3 INTERACTING MOLECULE, ISOFORM F; 1.
DR PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50916; RABBD; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 4..130
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 62..118
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 348..470
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 962..1081
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 140..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..542
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..795
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1125 AA; 127050 MW; 15A19AACEE5F2CD1 CRC64;
MEDGPDLSHL TPEERAIIES VMVRQKQEEE REKEIMRRKA TEVQLLEETI RARNEQFKKA
GNELDATCQI CLKTKFADGV GHLCNYCNIR CCARCGGKVT LRSNKVVWVC ILCRKKQELL
GKTGQWMIGG GGQLEIALDR SSHVHQQSQQ YMHHQQPPSD KRPKLERAHS AAEKENQPLQ
RSGSTLRRQF SEQDSNRGPS CERYQHQGYN EDDPRYYQGE IEGLMRQHPH LVPRRYPDSS
EPETSPMDVP SQRVSSVTSS NKKHKRTGST KKHQPHPPQP QIQKSFSSSE DDLRSTPECS
DDRDSEKGQM AQWPGSNSES YERPHVLVTS PGSPERPRQG NPPLAPSIGG RIQVRLSFDP
ATLQLLVTVV CAAGLVSRSP HQSRNPYCKL FLLPDRSEKS KRRTRTLAGT NDPMWNQTFV
YSGLRRNDLR QRALEITVWD YVRYGANDFL GEAIIELWPL EEQPLWRTLG PHEEIALTPS
EHLSPPSTGS RFSDSDTPSE CEIDGSRERR GADGASVSSV GSSISPPRET ERRSRRDQEP
LNPYNYRRNG MSGQRSHSAA PCESPSVHLS RSRSKSPRRS ATDHRSLSPP DVRIQDYQNY
TYPIPRFQSR SATATPTGSP KKRQLPQVPH ALARALQERV SQDLEERAFR QRGRYNTYRS
SGTGVWEKRY GGLSDSDLAN HSRLRRSYSP ERDRDTLGLV DFDSDMESVA SVTSSSFSTQ
SERPRGTRMI SASRPDSTEY SGGSDRYPYS GYRERERDRP YHNVNREQGI REPMEQHSNQ
EHHHHHHHRS YDHHHREGSV KRGQFTRSMS NTEVPADEKT DGSLSDTAVG QFHGLEANQN
EPARKENHGR ERDRDRANQF MGLSKKSNST SQLSATGRKR RMGFGRRGKT SFTVHRSEEV
LPGDVRISKQ GSSASSDGEG SVDGDRWSPS LRLAGESGQL ADFIDGLGPG QLVGRQVLGA
PALGDIQLSL CYQKGFLEVE VIRARGLQAR PGSKVLPAPY VKVYLVNGKK CIAKAKTSTA
RRTLDPLYQQ QLHFREPFQG CVLQVTVWGD YGRIEGKKVF MGVAQIMLDD LNLSNIVIGW
YKLFGTTSLV SGPPSLGLSR RSSIASLDSL KFEKLSRLLL WKRRR
//