ID A0A1W4WIX3_AGRPL Unreviewed; 1819 AA.
AC A0A1W4WIX3;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=MAP kinase-activating death domain protein {ECO:0000256|ARBA:ARBA00017868};
GN Name=LOC108733349 {ECO:0000313|RefSeq:XP_018319970.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018319970.1};
RN [1] {ECO:0000313|RefSeq:XP_018319970.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018319970.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the MADD family.
CC {ECO:0000256|ARBA:ARBA00005978}.
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DR RefSeq; XP_018319970.1; XM_018464468.1.
DR EnsemblMetazoa; XM_018464468.1; XP_018319970.1; LOC108733349.
DR GeneID; 108733349; -.
DR OrthoDB; 24616at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR039980; MADD.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR13008:SF7; MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR13008; MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000313|RefSeq:XP_018319970.1};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Transferase {ECO:0000313|RefSeq:XP_018319970.1}.
FT DOMAIN 19..641
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 136..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1092..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1293..1355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1036..1054
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1293..1329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1819 AA; 201989 MW; 71338472E0BB1534 CRC64;
MSSESERQFL CPRLIDYLTI VGVKSCNNTK SSSSTSVQAP ELLRRYPVQD HKDFPMPLDM
VYFCQPEGCS TVGPKRSALR EAQSFVFALT DKDSGKTRYG ICVNFYRPVE KTSAGGGGGR
GNSYLRRDSW RKSMEKSSDS AFSSDYRSSN IGPSDSERDF PSRRDSDAVG QPVPNTTQSC
VRLGITPIPN DSESGGSHSP SPRASRRRQK VRNNSLTSLC LLSHHPFFSM FRECLYVLRK
IIDACNESSS SKRVGASRQA GRDTVWSVLT GQATDTTPSI ILHDVREIET WILRLLSAPV
PIPGKTKVEV EIISSNIQEP LCFALPDHTR FSLVDFPLHL PLELLGVETC LKVLTLILLE
YKVILQSRDY NALSMSVMAF VTMIYPLEYM FPVIPLLPTC MSYAEQLLLA PTPYVIGLPA
TFLMYKKNFR LPEDIWVVDL DSNKLSNVGS SMEIPSLPEP ESTILKNHLK QALSGLTATT
SPTFQSLPVN REVQPVGNTL SVSMSKSKSP ETSPIMRNKP FKSLPSPFSQ PATPQQRSNA
VSPVSPIPFN PIIYGNDVDS VDVATRVAMV RFFNSQNLLA NFTEHTRTLR LYPRPVVAFQ
INSFLRSRPR SSQFINRFAR TQAVEFFAEW SLTPSNVAFQ RVQTGVLDPS QIGDKPKWYI
QTLETIKFVV WDEGSSLNSA LKCMQNQESQ PTDESGSDSE GAESTSSSFS SLSDFMSEMV
SSDISPGASN YEAKHSAAQK MTLSSNLDPQ SVYNPPSELR YPENFVPEKS SRPSSPQSTS
SSQSDLSSPS FNRDSESEMD QRRKNDIPTA KEEKEEVGSI ENESDSNSTA TPRTVISGGA
AKPGSSSSTT SESTEKSPIS RKSRYVPPIT PTLQKQPSIG NVLARTSSFG SSGSGSPALS
SGGSVDKVQR QSSQGSLFEQ FASQAKELML ETTRQSSQDG ILAQMDKFKT QARGKLSEAE
ESSLFAPFDK LASHAKKAAE EATKSVQEAG KTAIEASKSA ADASKTTFED LTYVGKSTLG
DLTKGAREVS KKALKRTDSG SQSGSDSRRG SSNSLVHAST GLIAGTSRDF FSNISSDLTD
IAQTTSSMFS DLFGSNKSTS RAQAQQQQQQ QQQQHSQTSQ QQKITKDTKS GIFGPFPRGP
KGLVEKSPLI KHTPRRQDDF QRIQSVERST TNIENQTFLK EVVNQVLEGE GVGWLKLNRL
KKLMEDESYR NFVLSKLNKT LERRIAPDDH IDDVCVSKSV WKGMLKVLLA SVHGLEYTYS
NFGLGGMASA FQLQEIAHTH YWSKDLSDSL YSDNPSHLLS SQGSSPRGSK ENLSSPQSPR
NSMSPDWDSS RKSSHAEPPQ VRLPQSDEAD VEQQQSTAEI FKDMLNQKKN LLLSKLTSFD
SDAENTMHGS GGTLSPGGSI TTGPACNLNR GGFQSSYRST VSDTEVETLQ FPKPTKQRTA
SVWSSKSSLS TGFRYHGGHM VNTLTSPSPE VARTYLFEGL IGKERSSLWD QMQFWEDAFL
DAVSQERDMI GMDQGPREMM ERYKSLSETE RKRLEHEEDR LLSTMLYNLT AVLVMLKCNK
AEIKKKIRRL LGKCHIGLVY SQEVNQLLDQ IEHLNGNDID LKPSLSRLLH RQSFTVHQGV
NGEGELRFME VRDDGLVLRS VSGVIIERWW YERLVNMTYS PKNKVLCLWR RSGQQTQLHK
YYTKKCKELY YCIKEAMERG GVAGKAPELG GEFPVQDMST GEGGLLQVCM EGVGLLFANS
KDFEFFVRID HIRKCFTQKG GIFVLEEFNP KTRQVIQRKY KSSMANDMLL SIHRIFSICM
TQRLSELYGV NDDNPSLPA
//
