ID   A0A1W4WIZ5_AGRPL        Unreviewed;      1706 AA.
AC   A0A1W4WIZ5;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Fascin domain-containing protein {ECO:0000259|Pfam:PF06268};
GN   Name=LOC108736104 {ECO:0000313|RefSeq:XP_018323899.1};
OS   Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC   Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX   NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018323899.1};
RN   [1] {ECO:0000313|RefSeq:XP_018323899.1}
RP   IDENTIFICATION.
RC   TISSUE=Entire body {ECO:0000313|RefSeq:XP_018323899.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   -!- SIMILARITY: Belongs to the FRG1 family.
CC       {ECO:0000256|ARBA:ARBA00010878}.
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DR   RefSeq; XP_018323899.1; XM_018468397.2.
DR   EnsemblMetazoa; XM_018468397.2; XP_018323899.1; LOC108736104.
DR   GeneID; 108736104; -.
DR   KEGG; apln:108736104; -.
DR   OrthoDB; 5484756at2759; -.
DR   Proteomes; UP000192223; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR   CDD; cd00257; Fascin; 4.
DR   Gene3D; 2.80.10.50; -; 4.
DR   InterPro; IPR008999; Actin-crosslinking.
DR   InterPro; IPR022768; Fascin-domain.
DR   InterPro; IPR010414; FRG1.
DR   PANTHER; PTHR12928; FRG1 PROTEIN; 1.
DR   PANTHER; PTHR12928:SF0; FSHD REGION GENE 1; 1.
DR   Pfam; PF06268; Fascin; 4.
DR   SUPFAM; SSF50405; Actin-crosslinking proteins; 4.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192223}.
FT   DOMAIN          1228..1341
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
FT   DOMAIN          1351..1465
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
FT   DOMAIN          1479..1587
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
FT   DOMAIN          1614..1706
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
FT   REGION          19..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          851..878
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        19..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..259
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1706 AA;  194639 MW;  6D5031C40958AFEB CRC64;
     MCNETYQCSS TRVERQNQTE TTFKSCKRNE PSSTSVKDNG NKNGLVVSTK SSSRQNIQKM
     FLELNKSRSD LDTKRNSSSS SSKNFKKKQQ HTLLKMLLQN AEYPWKKIKD KLNFYDTCNG
     NNCSSNTSNN VKKSRTPFTS HNLRKIEKED VTSIPLEANY VGHLSNNTGH LLLDKSTPLH
     CNCEYHQNAV TSEEIKCKRY IKNGLNRRET SLFHKPSQTF DYSKRVKTKP ADPARRSNSY
     PNQKYNEHPA GCNNNPPKHS ESFVNISKVK SANRDVNSEL LLHKSYKNYL VNPVFVHCNN
     PQFPNFDNQI TLHRTVSNHN LKSFDQTQDN GTITEEKPHT TVNIKINLEN KGQSQNSIIY
     CSQDDLYCNL LVDPSSPLCS HNADKQNGCH LRWYQCQKMA PFHKPASHCD NTTSYHETNN
     TGVKNVNVTS TQKPERINKM IQNDIHVKKD AYVQNPYREN KNIQTEKSGL MTGNKNTPCS
     SSRQRIKTNK NIYLVSVNNN RLGAESTSSV RRTSDNGLLS STNDADKCCY QNLSSQCDNK
     EQECVECPKL VPYSISSSDD INETEEQVEI IEKLQSQNKP NEITKCDRPY TKLSIDKNID
     KNTSKCVDIF YNFENKCNVF QCKVSKTKFV KPKRDTEKTF LNRYNCNRSQ LYKDIDKSEM
     ASSLSRISST QIEENAKVFL NGLEEAPWIC IFDGISNFKS GSDTSLNKKC EYTGNNSNNN
     FRAMLEVTNN GPKTENVENL PIMVLLNSEQ NGNTVSNLSL RSTVEEERNQ SKYLDVDKCC
     SIKNKPDMYK NITKNYGAID NETGHCDIKK GTGTRSRSIC SIMDYIKPLN KSVQFSSDYI
     TKDNLKIGYI ISRIEDLLNV LNDNIAEKLN NVKKKEHQTT NRNHIPKSFI NLTKTMENSD
     SRTDSVSSWE EPVKSSSKYI DFQKDANNNC NKEESVKKIK TRERNVKQPN STCNNTVVSL
     SFYNGAEQKN IDIVQEDTWK TRWLKRLCKN CESNKHLTYP TDSKIEIKNN LRKSTPNKQN
     SRVLNKDIKN DLWDKCNSTK TFYCNHCGSR WNEKIKIKNI TNLKSRNSEY GNSKIMLKKC
     PKCRKYTYII NKRQPKSARY NVSKKKCVSK TSVTSSSCLN VADNTSCHEI ILSMMNPKRQ
     EIQKSTKEDF YNAQYVADLR EETFLKMMEP KRRPATRDFP TMQKLTKQVS IMNGLNGHTN
     GDLNGCDIIT QNQQKGCWTI GLINSKFKYL TAETFGFKIN ANGASLKKKQ IWTLEPDLAT
     SGESYIYLKS HLDKYLAVDS FGNVTCENEE KDPGSKFLIS VAEDGTGRWA FRNVVRGYFL
     GASQDKLTCT AKIPGDAEFW LVHLAARPQI NLRSVGRKRF AHLSENQEEI YVDANIPWGE
     DTLFTLEFRA DESGKYALHT CNNKYLSLGG KLVDKCSSDC LFTAEYHSGY LALRDKNGSY
     LSPIGSKAVL KTRSNTVTKD ELFSLEDSLP QASFVAALNA KYVSVKQGVD VTANQDEISD
     HETFQLEFDW STKRWYIRTM QDRYWTLETG GGIQAAGDKR SSNALFDLIW QGDGSVAFRA
     NNGRYVTTKR SGHLYANSDA VDENSKYFFY LINRPILVLK SEQGFVGYKS GNNTKLECNR
     AMYETIQVER AEKGVVYFKG QNGKYWHCDN EGVTADSDIP EGFYLELREP TRLSIKSVNG
     SYLTASKNGV FRLGDSSYEN ATQWEY
//