ID A0A1W4WPC3_AGRPL Unreviewed; 207 AA.
AC A0A1W4WPC3;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 20 {ECO:0000256|ARBA:ARBA00019690, ECO:0000256|RuleBase:RU364152};
DE AltName: Full=Mediator complex subunit 20 {ECO:0000256|ARBA:ARBA00031954, ECO:0000256|RuleBase:RU364152};
GN Name=LOC108737430 {ECO:0000313|RefSeq:XP_018325771.1};
GN Synonyms=MED20 {ECO:0000256|RuleBase:RU364152};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018325771.1};
RN [1] {ECO:0000313|RefSeq:XP_018325771.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018325771.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364152}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364152}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364152}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 20 family.
CC {ECO:0000256|ARBA:ARBA00010743, ECO:0000256|RuleBase:RU364152}.
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DR RefSeq; XP_018325771.1; XM_018470269.2.
DR AlphaFoldDB; A0A1W4WPC3; -.
DR STRING; 224129.A0A1W4WPC3; -.
DR EnsemblMetazoa; XM_018470269.2; XP_018325771.1; LOC108737430.
DR GeneID; 108737430; -.
DR KEGG; apln:108737430; -.
DR InParanoid; A0A1W4WPC3; -.
DR OrthoDB; 2896803at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR013921; Mediator_Med20.
DR PANTHER; PTHR12465:SF0; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20; 1.
DR PANTHER; PTHR12465; UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49; 1.
DR Pfam; PF08612; Med20; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364152};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364152};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Transcription {ECO:0000256|RuleBase:RU364152};
KW Transcription regulation {ECO:0000256|RuleBase:RU364152}.
SQ SEQUENCE 207 AA; 23291 MW; 3A0F9812633EFDEA CRC64;
MGVTVVQNFP ITENRTGPST IELLTKRISA LGAIQQGHFL VDCETYTSVP QLGNPRTVHI
LHNSEQPATV FSILETENKT IPLATDGLFD LLMIKMANFY TSKKQTKAES KGPRYEIGDF
LVKLGTVTVS QNFKGVLVEV EYRPCVVPAM CWELMREFLQ GFLGSTAQSA PPLYLQNRMQ
DIYSPIDTIH QYLEQFTIYR KAPGLRT
//
