ID A0A1W4WPE7_AGRPL Unreviewed; 1318 AA.
AC A0A1W4WPE7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN Name=LOC108734801 {ECO:0000313|RefSeq:XP_018321983.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018321983.1};
RN [1] {ECO:0000313|RefSeq:XP_018321983.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018321983.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
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DR RefSeq; XP_018321983.1; XM_018466481.1.
DR STRING; 224129.A0A1W4WPE7; -.
DR EnsemblMetazoa; XM_018466481.1; XP_018321983.1; LOC108734801.
DR GeneID; 108734801; -.
DR KEGG; apln:108734801; -.
DR InParanoid; A0A1W4WPE7; -.
DR OrthoDB; 2875749at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50156; SSD; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 305..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 304..462
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REPEAT 1154..1196
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1318 AA; 148923 MW; 9A286B3E2A2FA11D CRC64;
MNALAQDTRP SRGATNSAKA AAAAKTSHTR GKHPTGLQDK VAQLYYSHGL FCSTYPATVI
SIAISVVLLC CYPLLNLPLP GNSSIQIWNT INESTKVVSH GGDPPWCYVQ QIVVRSSVVP
WDQTLHLGDA FRAPLYEAFK LLEVVRNYED PKSLKTFDHV CLHVESLKKT KDERNYVFPE
YGCLILSPAN LWHQDVQQFM QDSSILSTIF NHQDLQKGKI SHAELLFGMH MSDTGIKRYP
LRNRQRVLQY AITLFLRDYN EAFVSGLKNK LQKLYPLNQN VENSTTTNNE IVSIYYPDEL
NYSEFIPLGT SFCLLFVYYY FSVRKIELIK SKCGMAFTAV MTVLGSLTMT LGLCFFFGLT
LSLRVKEIFP YLVILVGLEN VLVLTKSVTS APLHLDIKIR VAQGLSKEGW SITKTLLIEI
TILTIGLFTF VPAIQELCIF AIVGLLTDFF LQMLFFSTIL SVDIKRKENL VEKNNISFRN
ALYQGHFYPE KTLNTGMNRS KSHPKLSSAH TDVVASQSHQ LDRRIPKRVK LVNIWARTRF
FQRAFMFLMV VWIGRILYDS GIVENYFLDS RVAENRTNDR SSEERSLKFR PQLNRTLNVN
FLTDTVSESD IMKQKNHTEE LRKLRHPEFS TSRRLSAQHW PTILKKYNIS VSGRSVVILP
SIKLSHAISP EQAALLRNSE EVYGQKFQWQ ALAAALDPID FTDSESDSSS DHLLSLSERP
FYPNSPMEIF LTTILCFISI IVMAYTFVVL YRCICSRNYA EWRASWFNNG DKTEENDVPV
LLEAVPIVLK GHPQEIECIV TDGFSAASSC LGGQIKVWDT NTGDLLAKID RNSLHNNGPC
SRSPELSMDN GDDCNLSDYE SGSPASHDDL LPTFPSLQHK ININFSGLRL RADRTNTLYD
FGNDYRELYA EFQRLQRLKR RNNDTARWVH VQRQYSRSGD FEIDNNGGMT SYDCLEKDEA
LKKSPRNYKC EFFNDSRATN GGINSNDCVN KPSPIWCMDY VDNLIAIGCA DGTLEFWEGT
TGKFKCLYND NSGVAITSIK IIGSRAVVVR LLGTVDFLQL QTFNHGRPVD WNFTSAYRRT
HTRTASAGSL SEIKNATLQD ESLEEMVCLK VMSLKAHQQP ITCLDSEGGR VVTGSQDHTL
KVFRLDNGSA LYTLHGHYGP ITSLFIDRVC PATSGSGSQD GTLCVWDLLT GACMYSNKAH
DGAITSLTYS ASYVISLGMD ERLCIWERFQ GHLLNTINVS NSFPTKVMML TPHLVLTTRQ
GGLVVWDVRT GECVRTIVLG RSALVFVNQM IMLRDSVLCD FGNELRIVRF PLITHKCD
//