GenomeNet

Database: UniProt
Entry: A0A1W4WPE7_AGRPL
LinkDB: A0A1W4WPE7_AGRPL
Original site: A0A1W4WPE7_AGRPL 
ID   A0A1W4WPE7_AGRPL        Unreviewed;      1318 AA.
AC   A0A1W4WPE7;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN   Name=LOC108734801 {ECO:0000313|RefSeq:XP_018321983.1};
OS   Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC   Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX   NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018321983.1};
RN   [1] {ECO:0000313|RefSeq:XP_018321983.1}
RP   IDENTIFICATION.
RC   TISSUE=Entire body {ECO:0000313|RefSeq:XP_018321983.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC       membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC       {ECO:0000256|ARBA:ARBA00007410}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_018321983.1; XM_018466481.1.
DR   STRING; 224129.A0A1W4WPE7; -.
DR   EnsemblMetazoa; XM_018466481.1; XP_018321983.1; LOC108734801.
DR   GeneID; 108734801; -.
DR   KEGG; apln:108734801; -.
DR   InParanoid; A0A1W4WPE7; -.
DR   OrthoDB; 2875749at2759; -.
DR   Proteomes; UP000192223; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR030225; SCAP.
DR   InterPro; IPR000731; SSD.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR   Pfam; PF12349; Sterol-sensing; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50156; SSD; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
PE   3: Inferred from homology;
KW   Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW   Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   TRANSMEM        305..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        371..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        416..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        440..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        729..751
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          304..462
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REPEAT          1154..1196
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          838..867
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        838..862
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1318 AA;  148923 MW;  9A286B3E2A2FA11D CRC64;
     MNALAQDTRP SRGATNSAKA AAAAKTSHTR GKHPTGLQDK VAQLYYSHGL FCSTYPATVI
     SIAISVVLLC CYPLLNLPLP GNSSIQIWNT INESTKVVSH GGDPPWCYVQ QIVVRSSVVP
     WDQTLHLGDA FRAPLYEAFK LLEVVRNYED PKSLKTFDHV CLHVESLKKT KDERNYVFPE
     YGCLILSPAN LWHQDVQQFM QDSSILSTIF NHQDLQKGKI SHAELLFGMH MSDTGIKRYP
     LRNRQRVLQY AITLFLRDYN EAFVSGLKNK LQKLYPLNQN VENSTTTNNE IVSIYYPDEL
     NYSEFIPLGT SFCLLFVYYY FSVRKIELIK SKCGMAFTAV MTVLGSLTMT LGLCFFFGLT
     LSLRVKEIFP YLVILVGLEN VLVLTKSVTS APLHLDIKIR VAQGLSKEGW SITKTLLIEI
     TILTIGLFTF VPAIQELCIF AIVGLLTDFF LQMLFFSTIL SVDIKRKENL VEKNNISFRN
     ALYQGHFYPE KTLNTGMNRS KSHPKLSSAH TDVVASQSHQ LDRRIPKRVK LVNIWARTRF
     FQRAFMFLMV VWIGRILYDS GIVENYFLDS RVAENRTNDR SSEERSLKFR PQLNRTLNVN
     FLTDTVSESD IMKQKNHTEE LRKLRHPEFS TSRRLSAQHW PTILKKYNIS VSGRSVVILP
     SIKLSHAISP EQAALLRNSE EVYGQKFQWQ ALAAALDPID FTDSESDSSS DHLLSLSERP
     FYPNSPMEIF LTTILCFISI IVMAYTFVVL YRCICSRNYA EWRASWFNNG DKTEENDVPV
     LLEAVPIVLK GHPQEIECIV TDGFSAASSC LGGQIKVWDT NTGDLLAKID RNSLHNNGPC
     SRSPELSMDN GDDCNLSDYE SGSPASHDDL LPTFPSLQHK ININFSGLRL RADRTNTLYD
     FGNDYRELYA EFQRLQRLKR RNNDTARWVH VQRQYSRSGD FEIDNNGGMT SYDCLEKDEA
     LKKSPRNYKC EFFNDSRATN GGINSNDCVN KPSPIWCMDY VDNLIAIGCA DGTLEFWEGT
     TGKFKCLYND NSGVAITSIK IIGSRAVVVR LLGTVDFLQL QTFNHGRPVD WNFTSAYRRT
     HTRTASAGSL SEIKNATLQD ESLEEMVCLK VMSLKAHQQP ITCLDSEGGR VVTGSQDHTL
     KVFRLDNGSA LYTLHGHYGP ITSLFIDRVC PATSGSGSQD GTLCVWDLLT GACMYSNKAH
     DGAITSLTYS ASYVISLGMD ERLCIWERFQ GHLLNTINVS NSFPTKVMML TPHLVLTTRQ
     GGLVVWDVRT GECVRTIVLG RSALVFVNQM IMLRDSVLCD FGNELRIVRF PLITHKCD
//
DBGET integrated database retrieval system