ID A0A1W4WTA8_AGRPL Unreviewed; 1450 AA.
AC A0A1W4WTA8;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Receptor-mediated endocytosis protein 6 homolog isoform X1 {ECO:0000313|RefSeq:XP_018323265.1};
GN Name=LOC108735689 {ECO:0000313|RefSeq:XP_018323265.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018323265.1};
RN [1] {ECO:0000313|RefSeq:XP_018323265.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018323265.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GAPVD1 family.
CC {ECO:0000256|ARBA:ARBA00008489}.
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DR RefSeq; XP_018323265.1; XM_018467763.1.
DR STRING; 224129.A0A1W4WTA8; -.
DR EnsemblMetazoa; XM_018467763.1; XP_018323265.1; LOC108735689.
DR GeneID; 108735689; -.
DR KEGG; apln:108735689; -.
DR InParanoid; A0A1W4WTA8; -.
DR OrthoDB; 20678at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|RefSeq:XP_018323265.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223}.
FT DOMAIN 144..360
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1311..1450
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 480..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1450 AA; 162203 MW; B822AF8A5A7EF948 CRC64;
MDKRKDMDNI DSKAIDIIEL ITQLRNERLF VVSELKAIKA ANEKVREIID KLTQAAWMNL
QKRIILNMLA MSSSKATAIK CWQNLNNLTN TVFVHAKDVL NQETSQFGEL LQILRSKPEM
LSHLLVLGIT ESSLQEEAKN VINSLTSGLY GALLLPEDVS LVLSLLQHLA KLELVTADNP
RRKLRRKCCA FSQLYFLFHE NLPAAKLFLT AALRKPIMQV IAKKDGYLDV DPEKTLSRFM
HKKTNTRCLS EDEEIGQFRR KTVDELVYFA TYFIRSIRES INCFPGSFAW LIGHVSDLMT
KTYGILSREV REVNTDLIFT LFICPAIVHP EAYGICDISI CEVVRHNLMQ VAQILQAIAL
FNFNDLEPKY ADFYALFEQE SVYDIIGDLL KNSTNEHELG IDHVPEVART SVLFTLEELH
NLVAFLQKAI TVANLSDDQD GPRKYLLQSI RKSTCFPSLK LITFLLNNLI TVQQQQQSSE
INRSSLITKS GGKGTQKKRS SSPNGGSGNK VKPTAVLVIP IHQDKIQHIG LLPEHKVVGI
ESTDEDNDRS PNELEPPENQ TGSTIGIASS AIGSEKRIRF SRSHDESSVG NTSDNLEAVS
EAASNHSVDS SVELENEDQN DNLSDMISAN VSGRGTPNIS GRDTPSSQVN DDEEGDVVEE
PREAIEQEAT IEVPEPPLPP ARRQVQIIDK HTQNEIDDKF CKFEIKRILE GEETRSIISD
TWSTDVLASD CETIDGNDVR GDQQNINLIM ETGTLIGSAP PSGGTPLLDM SETKSESGWS
TDVLASDSER LTEVDADDIS VARLEDAVSI GRSDDGAGAI TEANSAKVTE HLKVNVLDLP
CRSSSISQDD VNSRGRCNCQ RCVLEYSVAG TNTSATTVAY QSINNFLQDA DDGSERPEVR
SSKSSSVQDQ QRLSNNSEYN SNSSSSCSTS SLESHNKDSQ MGEKNEGNEV RVINTTPKKP
EGSFASSVLK STSLNGAIPK SISFDMTAEK GSDDEQKEKR SFLGKFRIGF RNRRAKTMRE
AEEVQMTNAN TVGPTLRRTL SEESSNFSFT GMCDDILAKY RKTVGDGTNS EVKVTVLDNA
KVTERNKSPS ASCSDEHDKN LGFSNVKKKL RLVLSNSCGY HSTIRVGGTG QVKSDLESYL
QLELAKAHKL KCRSSARIAE ALRCVKMFDE ENCHKLCTIL KEDYCQRSVY IQYLIQSRQL
LLSILAFLEG LSEQIESEKE LSSSYMATTC VKFFLERHEI EMAKFKKEFS QLTMVDEKCF
HLKEFLQTLN LLIRKETVWQ DDMELVEVAM ERSVINEVYY NALYPNGDGD KDRDSVLRDH
LQKLSKVINP NHKDLMISPC FQHECPWLPA QEALQDMASY RTPRDKVSCV LRSTMAIKDL
LSLIGSKIPT ADDFTPILVY VIIKANPPSL LSTIQYVNGF FGDWLQGEDL YWWTQFCAAV
EFTKTMDYCD
//
