ID A0A1W4WTH9_AGRPL Unreviewed; 508 AA.
AC A0A1W4WTH9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=G-protein coupled receptor Mth isoform X4 {ECO:0000313|RefSeq:XP_018327206.1};
GN Name=LOC108738325 {ECO:0000313|RefSeq:XP_018327206.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018327206.1};
RN [1] {ECO:0000313|RefSeq:XP_018327206.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018327206.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. Mth
CC subfamily. {ECO:0000256|ARBA:ARBA00008979}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_018327206.1; XM_018471704.2.
DR AlphaFoldDB; A0A1W4WTH9; -.
DR EnsemblMetazoa; XM_018471704.2; XP_018327206.1; LOC108738325.
DR GeneID; 108738325; -.
DR OrthoDB; 3108840at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15039; 7tmB3_Methuselah-like; 1.
DR Gene3D; 2.170.180.11; Methuselah ectodomain, domain 2; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR023311; Methusela_ecto_dom_2.
DR InterPro; IPR036272; Methuselah_N_sf.
DR PANTHER; PTHR47154; G-PROTEIN COUPLED RECEPTOR MTH-RELATED; 1.
DR PANTHER; PTHR47154:SF2; G-PROTEIN COUPLED RECEPTOR MTH-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR SUPFAM; SSF63877; Methuselah ectodomain; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_018327206.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..508
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010705304"
FT TRANSMEM 183..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 181..459
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 508 AA; 58579 MW; C9AD00472F7A6C96 CRC64;
MSSYSIRSFP FLLVLINVII NVVVSIDTNP CDEEFSVDIT DGEVFPNGTI LKDGILYSED
YYFYVNESIA KGCICELAKC VRKCCPKGEY MSKRKCVPST GPSELPINGN VRGGRIIIGN
TCSEDRVRLL QSNFSEDSDL ILEEDGSLTV FGETFTYHDY CIDFIDTFSE LRALTCFEEE
QELTHYVGMI ISLPCLFITF LVYFLDPNRN FHGMCLMCYV STLFCAYVFL IILQLHSDFE
MSVCTALGIL CYFFFLVSFF WLNIMCIHMW RIGGQQNFSR SKKANRNRFL AYSAYAWGVP
LIMTGIVVAL RFSFPEESNW LPSIGIRQCW FNDDLQSLIY FYGPVTVLIT INITLFAITA
IKILKAKKDT AILRKDEKER KTLLQRFLHR GPIKRSIQVE GFNLYSKLVL AMGVNWAMEV
ISFYFRFVDH MSPKWIWYFT DFCNACYGVF IFFVYAFKKV WTICKVRYYK MTGKPYEEKT
VTQSTPRTVT SNVSYATSNN AESTAMIS
//
