ID A0A1W4X335_AGRPL Unreviewed; 507 AA.
AC A0A1W4X335;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=G-protein coupled receptor Mth isoform X5 {ECO:0000313|RefSeq:XP_018327207.1};
GN Name=LOC108738325 {ECO:0000313|RefSeq:XP_018327207.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018327207.1};
RN [1] {ECO:0000313|RefSeq:XP_018327207.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018327207.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. Mth
CC subfamily. {ECO:0000256|ARBA:ARBA00008979}.
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DR RefSeq; XP_018327207.1; XM_018471705.2.
DR AlphaFoldDB; A0A1W4X335; -.
DR EnsemblMetazoa; XM_018471705.2; XP_018327207.1; LOC108738325.
DR GeneID; 108738325; -.
DR OrthoDB; 3108840at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15039; 7tmB3_Methuselah-like; 1.
DR Gene3D; 2.170.180.11; Methuselah ectodomain, domain 2; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR023311; Methusela_ecto_dom_2.
DR InterPro; IPR010596; Methuselah_N_dom.
DR InterPro; IPR036272; Methuselah_N_sf.
DR PANTHER; PTHR47154; G-PROTEIN COUPLED RECEPTOR MTH-RELATED; 1.
DR PANTHER; PTHR47154:SF2; G-PROTEIN COUPLED RECEPTOR MTH-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF06652; Methuselah_N; 1.
DR SUPFAM; SSF63877; Methuselah ectodomain; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_018327207.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..507
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010704341"
FT TRANSMEM 184..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 180..458
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 507 AA; 57813 MW; BF719CBE20C449C2 CRC64;
MAFGGGTLIA FFCIVIVIYI TAVSAENPCS EEFSVDISDG IVSQDNSIVK DGVTYSAGQY
YYYNSTNIRG CVCEVKKCIR KCCPIGEYMT NKTCLPTDQP LILPGDTPPN INDYHVLVGS
TCPENKVRTR ASEDNDDIAL QNDGTLIAFG NGYSYEDYCV DYIEDLTRSS ALVCIEPTAQ
STQHSVGMII SLPCLFITFL VYFLDPNRNF HGMCLMCYVS TLFCAYVFLI ILQLHSDFEM
SVCTALGILC YFFFLVSFFW LNIMCIHMWR IGGQQNFSRS KKANRNRFLA YSAYAWGVPL
IMTGIVVALR FSFPEESNWL PSIGIRQCWF NDDLQSLIYF YGPVTVLITI NITLFAITAI
KILKAKKDTA ILRKDEKERK TLLQRFLHRG PIKRSIQVEG FNLYSKLVLA MGVNWAMEVI
SFYFRFVDHM SPKWIWYFTD FCNACYGVFI FFVYAFKKVW TICKVRYYKM TGKPYEEKTV
TQSTPRTVTS NVSYATSNNA ESTAMIS
//
