ID A0A1W4X3K3_AGRPL Unreviewed; 1369 AA.
AC A0A1W4X3K3;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=ATP-binding cassette sub-family A member 2 isoform X2 {ECO:0000313|RefSeq:XP_018330706.1};
GN Name=LOC108740753 {ECO:0000313|RefSeq:XP_018330706.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018330706.1};
RN [1] {ECO:0000313|RefSeq:XP_018330706.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018330706.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_018330706.1; XM_018475204.1.
DR EnsemblMetazoa; XM_018475204.1; XP_018330706.1; LOC108740753.
DR GeneID; 108740753; -.
DR OrthoDB; 773084at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF250; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 3; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840,
KW ECO:0000313|RefSeq:XP_018330706.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 82..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 769..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 809..835
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 847..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 877..900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..930
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 990..1008
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 230..458
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1057..1287
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1369 AA; 155049 MW; CA19051B65EC4DED CRC64;
MKIMGLPEWM YWLSWFINIL IFYVISIVFI ILLLKIQWFS NRRKVFARAN PIILFIFLFL
FACATSVFAF MISIFFKKAS NASAAAGLIW VFSYVPFLSI KTNYEGVHLG LKIFSCISSN
TALGFGMKQL VAFEAHENGL QWDNIWGRSS PDDSFVFGYV LVMLLVDCVI YIVLAICLEN
FFVGNRVKEH VLHILYKIRK KIKAPWKKET TTTSTVQNKD SNEPFPQSGI VVKKLTKVFA
GKEVVKNVSM TVYQDQITVL LGHNGAGKTT LLSMLTGSLS PTDGTATIGS RDILKEKHRQ
NLGFCPQFDI LLDELTVSEH LYLFCKIKGM VDAKLITEEI DKYVDMLSLQ PKKNARALTL
SGGMKRKLCV GIALCANSKF VIFDEPSAGM DPKAKRGLWD VLQSQKDGRT LILTTHSMDE
ADIVGDRIGI MLDGKLECID TSFALKKKYG LGYFLIVEIV PYANVTKTTA VLKTVIPDIQ
IETATSFEIK YRIQESYSKQ LPQLLKMLEE NGKTLEIIRF GVSFTTLGDV FSQVLVSPSD
QEDNKLQETG NLNMSIDGSE QLSEIFTEGS KKNSRGYSLY LYQFLAMLMK RAFLFRRSLF
LFVLQITVII TLTAIAISIG REASNIRQPA LSINLKAYKN ATTAVTGQTN NIYYKSYRRA
ALKDSSHLKD WKDGDFSDNM LHETVKNMDL VRTNYIVGAS FHSNNVTAWF NNIPLHSAPL
SLSMIINAIL EEEVDAQHHI SFVQHPVDFG SRSKLDRIFH SKSVGYQLAF YYGFAMAFIS
SFFLIVYIYE RQNKFKHLQF ISGVKLSVYW LTSILWDAII FAVMIVITII TLVCFQEDGY
STSDDFWRLS ILLGCFAFSS LSTTYVLSFA FNSSASGFVW MSVLNLFTGV TSFMVVGILR
DEIINLSDTA DSLHKIFIIF PHYALPVAMA DMHRIFSLRK VCYEMIMDCA DRLSIDSSLS
CSDLICNRAS ACCNLETDYW DWDEPGIGKI LIYQVIVGGI FFIILCMIES NILSVFRRFK
TSFVEIHREN ITDDDVNQEK NNVNFILESN IENQYAVVLK DMSKTYKGNI AVNRLNLAVM
PAECFGLLGQ NGAGKTTLFK MMTGDISITY GNAWLEGNSV KEEIGKVRKS IGYCPQYDAL
LNELTGKEIL IIFCLIKGIR LKNIKGSITK LAELFNFSEY LNKKSGKYSG GNRRKLSTAI
AFTGNPSLVY LDEPSTGMDP ASQRHIWKIL HRLRASGTSI ILTSHSMEEC EALCTRLAIM
IHGSFRCLGS IQHLKHKFMG GYILSIKVLE YKLEVVEQFV KENFKNANLK EKFVGFLRYH
IQELTVPLWK MFSLLEERKQ KTDIEDYSLG QAGLEQIFIY FVESTETQQ
//
