ID A0A1W4X4N7_AGRPL Unreviewed; 910 AA.
AC A0A1W4X4N7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Glutamate receptor ionotropic, kainate 2 isoform X2 {ECO:0000313|RefSeq:XP_018331081.1};
GN Name=LOC108741015 {ECO:0000313|RefSeq:XP_018331081.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018331081.1};
RN [1] {ECO:0000313|RefSeq:XP_018331081.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018331081.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR RefSeq; XP_018331081.1; XM_018475579.1.
DR AlphaFoldDB; A0A1W4X4N7; -.
DR STRING; 224129.A0A1W4X4N7; -.
DR EnsemblMetazoa; XM_018475579.1; XP_018331081.1; LOC108741015.
DR GeneID; 108741015; -.
DR InParanoid; A0A1W4X4N7; -.
DR OrthoDB; 1011589at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:UniProt.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF422; KAINATE-TYPE IONOTROPIC GLUTAMATE RECEPTOR SUBUNIT 1D; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_018331081.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..910
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010718261"
FT TRANSMEM 552..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 421..792
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 431..496
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 910 AA; 102922 MW; 59465D27C4920F77 CRC64;
MDSKLEIFLL ILNIHHVLLL PDVIRIGGLF HPADDKQELA FKYAVDKINN DRTILPRSKL
SAQIERMSPQ DSFHASKKVC HLLRSGVAAI FGPQSPQTAS HVQSICDTME IPHLETRWDY
RLRRESCLVN LYPHPTMLSK AYVDLVKAWG WKSFTIIYEN NEGLVRLQEL LKAHGPYEFP
ITVRQLGEGP DYRPLLKQIK NTAESHIVLD CTTEKIYDVL KQAQQIGMMS DYHSYLITSL
DIHGVDLEEF KYGGTNITAF RLVDPDGPEV RKILKVWQAM AVNDNNRNRK PESNQFVDNR
TFVKAETALM YDAVHLFAKA LHDLDTSQQI DIKPLSCDAV DTWPHGYSLI NYMKIVEMRG
LTGIIRFDHQ GFRSDFVLDI VELGREGLKK IGSWNASRGV NFTRTYGEAY TQIVEILQNK
TFVVTTILSS PYIMRKDSTE KLTGNSQFEG YAVDLIHEIS RILGFNYTIR LAPDGRYGSY
NKKTKEWDGM IKELLDQKAD LAIADLTITY DREQAVDFTM PFMNLGISIL YRKPIKQPPN
LFSFLSPLSL DVWIYMATAY LGVSVLLFIL ARFSPYEWEN PHFCIHESTV LENQFTLMNS
LWFTIGSLMQ QGSNLAPKAV STRMVAGMWW FFTLIMISSY TANLAAFLTV ERMDSPIESA
EDLAKQTKIK YGALRGGSTA AFFRDSNFTT YQRMWSFMES ARPSVFTMSN TEGVERVVKG
KGSYAFLMES TTIEYVIERN CELTQIGGLL DSKGYGIAMP PNSPFRTAIS GAILKLQEEG
KLHVLKTRWW KEKRGGGACN DETTKTSSTA NALGLANIGG VFVVLMGGMG VACVIAVCEF
VWKSRKVAIE ERISLCSQMA SELRFILKCS ESSKPVHPLK TSDATTMVDG NFPRLGSYPY
GFVLDKEPIN
//
