ID A0A1W4X7H7_AGRPL Unreviewed; 2777 AA.
AC A0A1W4X7H7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Protein unc-13 homolog A isoform X2 {ECO:0000313|RefSeq:XP_018331994.1};
GN Name=LOC108741634 {ECO:0000313|RefSeq:XP_018331994.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018331994.1};
RN [1] {ECO:0000313|RefSeq:XP_018331994.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018331994.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_018331994.1; XM_018476492.2.
DR STRING; 224129.A0A1W4X7H7; -.
DR EnsemblMetazoa; XM_018476492.2; XP_018331994.1; LOC108741634.
DR GeneID; 108741634; -.
DR InParanoid; A0A1W4X7H7; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF12; UNC-13, ISOFORM E; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1586..1636
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1692..1816
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 2124..2267
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 2378..2544
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 2604..2730
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 440..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1172..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1349..1523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2571..2600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 194..221
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 261..288
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2308..2335
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 440..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..753
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1032
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1200..1234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1349..1388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1421..1453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1460..1488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2571..2596
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2777 AA; 313866 MW; 848AD50CB29D4D93 CRC64;
MENITDAMAP ISADQNCDGN MDYIISDYME RLSTRLGILE TELKYAWRAL DLLSQEYIKM
WERLEKLEGL LYDQQSVISQ LLGFYTRGAD ILQEMGGDVG LKLDSRMGQL EVIREILGNG
TVEDGLEEGV DVAKPSNHSN SKISEGIDFS SELADTRDPD EAFYRSLNQA YREDLIGCEQ
MRPSPHLGMI WEEETEEVND IDKTREEIKR LEDAARYEET QEVFSAIDYK DYRGNSPCVS
EQDLAQLSSI DHITMEKLSE LDRLSSKIKE DSFNIQQLQN QLLEAEAKDE CGKPDDHMQK
FLNDSEMWKF MSSPSLSNRP SSRISLPESI VGTDNEVAET LSGGIKTPTS PRRRHQVVSC
SEPYTTVTGR LAYTTAVQNA EAAEFLQKTS ASKNPFYNSI LEMNRLNETS FPSSYASKEN
FITRAEKPLS PTLSICSVRT RQDGYIDSPT GAEQVQKNSK TPSNTPPPPP APVDALESLV
VSKDSFIITS DLTGSIFLST SAATSTTLAN HDIDRLSPRT PHSPKSPRTS PKRSKANIMA
AKSDSGLSSM SGWSSLEKSP QGSPKSAVNS KTCSLNYFLE MSLSRHQKSA SPVCQEAFVS
SAPINNDIEN NSMYANDALD NSAVLPGGHR LSAFTTVKSP CSLESSGNFV PAPAPASDIN
VSPRSKTKFR HMKANSFSYS TADSSVIYSI AATNKDEAFR SVYTMGHFDN TLSANYPDVV
EPFGDGETYN SKKYNQSQPV RNHEKRKKIN KDFSFETNPS YESQESYKQY GHRSGYPTGN
ITDALSYYPT AARYEVIPQQ RKRSQSTGNY PEENITSQNR ENVGQRPPEN TNGYMAYPDK
RLSYQYYRTN ETHHFQQPAD FNNASGNQRP DIPYLELDLK NKNVPEYITQ PSTKPYETDN
LLMTRTGYIT ITQEFNRNQK SPKKLRRGKT LKSAMNSVSN WFPDLHLTKR HRSYSLPSGA
KNSKAGEDQN KNIAQALPKK KKKNILVSTV SGLMHRGRKK DPQGQSLSDP EQSENEWSLT
MESSAASEED DSFSLLSESH AEKDDVFALI PQRTPNEVIN TREEEEEIAQ INSHSVNIQD
LDTNSVNQNS EDDELLVETA ALMFATIGDV KRSSASSETQ DEGPNTETKQ LPQVTLASME
FAVSRALGKY RQRQTSTYSD DQISDEIKIE EIFDEPDIEQ EAVTEPKASK PPNIPQLPPS
SLPEEESVTE EIQSSTNFRS NRWTNKQQQS LEIPNFRSED EDNRSTHSWR SGSRVSSRRQ
STEDSIDSED EWYRYELKKL EEMEKQSVTD FEIGEALQDV PEVDEPFEPD EHIKEKMSFV
LQELKLKTKI VEGVLDEKDY NMQVIASAKR REAEKEEFQD EPPAAEYQGE NEDEKYDTEK
DEYEEKSSSV TSGPDSPQPE EFDDGDLAAD FALCSKISQL NEDDNEPRID NQSEAQLKDF
ASDKDEKNDA QQSESSKDAT SRWKLLKALK ERKAEEKTNQ DKTSEPVPEK DNNGCGIGGD
SGGRADGHPG DNPFYSNIDS MPDIRPRRKS IPLVSDLVLK TMAATKRNAG LTSAVPRATL
NDEELKMHVY KKTLQALIYP ISSTTPHNFV LWTATSPTYC YECEGLLWGI ARQGVRCTEC
GVKCHEKCKD LLNADCLQRA AEKSSKHGAE DKANSIITAM KERMKQRERE KPEIFELIRA
VFGVEDKSHV GHMKAVKQSV LDGTSKWSAK IAITVKCAQG LIAKDKSGTS DPYVTVQVGK
VKKRTRTMPQ ELNPVWDEKF YFECHNSSDR IKVRVWDEDN DLKSKLRQKL TRESDDFLGQ
TIIEVRTLSG EMDVWYNLEK RTDKSAVSGA IRLHISVEIK GEEKVAPYHV QYTCLHENLF
HYLCEQNSGV VNLPQAKGDD AWKVYFDEAP EEIVDEFAMR YGIESIYQAM THFHCLSTKY
LCPGVPAVMS TLLANINAYY AHTTASSAVS ASDRFAASNF GKEKFVKLLD QLHNSLRIDL
SMYRNNFPAS SHEKLMDLKS TVDLLTSITF FRMKVQELSS PPRASTVVKD CVKACLRSTY
QFLFENTYEL YNREFQADPN EPKRDPEDHG PRLDSVDFWH KLIALIVSVI EEDKNSYGPV
LNQFPQELNI GQLSAATMWS LFAVDMKYAL EEHEQHRLCK SSAYMNLHFK VKWLYTNYVK
DVPPYKGAVP EYPSWFEPFV MQWLNENDDV SLEYLHGAFN RDKKDGFQKS SEHALFSNSV
VDVFTQLTQC FDVVSKLECP DPEIWKRYMK RFAKTIVKVL IAYADIVKRE FPEHLKEERI
ACILMNNIQQ LRVQLEKMFE SMGGEKLEED AANILKELQQ SLNGALDELA SLFASSLEPR
ITQSVKELGD LLLAIKGGGQ PGTLNQPAQR NAVAVEADEV LRPLMDLLDG SLSLYAQSCE
KTVLKRLLKE LWKIVMRILE KTVVLPPMTD KTMVFKSLTD NAKNLAANTK IEDMSRIFKN
HMTGKQDVKN ALSGVMDISK EVEKNLSPKQ CAVLDVALDT IKQYFHAGGN GLKKAFLDKS
SELQSLRYAL SLYTQTTDTL IKTFVTSQVN EVPLNNKETM LQRQISIERE DTETGLESLE
EPLKAKKKRE NRQDTTDSQE GCVGEVSIQV DLFTHPGTGE HKVTVKVVAA NDLKWTVVSG
MFRPFVEVNL IGPHLSDKKR KHATKSKANN WSPKYNETFH FIIGNEEQLD FYELHICVKD
YCFAREDRLV GVAVMQLKDI VDRGSCACWL SLGKRIQMDE TGWTILRILS QRTNDEVAKE
FVKLKSDIRQ ENLPPNN
//
