ID A0A1W4X7L0_AGRPL Unreviewed; 2917 AA.
AC A0A1W4X7L0;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Zinc finger homeobox protein 3 isoform X4 {ECO:0000313|RefSeq:XP_018328822.1};
GN Name=LOC108739418 {ECO:0000313|RefSeq:XP_018328822.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018328822.1};
RN [1] {ECO:0000313|RefSeq:XP_018328822.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018328822.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR RefSeq; XP_018328822.1; XM_018473320.1.
DR EnsemblMetazoa; XM_018473320.1; XP_018328822.1; LOC108739418.
DR GeneID; 108739418; -.
DR OrthoDB; 4180951at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00086; homeodomain; 4.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR Gene3D; 1.10.10.60; Homeodomain-like; 4.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45891; ZINC FINGER HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR45891:SF3; ZINC FINGER PROTEIN 2; 1.
DR Pfam; PF00046; Homeodomain; 4.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00389; HOX; 4.
DR SMART; SM00355; ZnF_C2H2; 22.
DR SMART; SM00451; ZnF_U1; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR SUPFAM; SSF46689; Homeodomain-like; 4.
DR PROSITE; PS00027; HOMEOBOX_1; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 410..439
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 892..920
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1036..1066
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1079..1101
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1107..1135
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1237..1266
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1281..1312
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1355..1384
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1448..1478
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1607..1635
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1840..1900
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 2101..2161
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 2192..2219
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 2432..2492
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 2704..2764
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 1842..1901
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 2103..2162
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 2434..2493
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 2706..2765
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1179..1206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1313..1351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1406..1443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1485..1507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1544..1605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1661..1729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1930..1949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2236..2334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2546..2565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2604..2710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..84
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1313..1344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1553..1571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1590..1605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1690..1729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2237..2269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2281..2332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2547..2565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2613..2627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2660..2674
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2677..2710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2917 AA; 324331 MW; 613BCD4A419BC1E5 CRC64;
MPTLSAAPEL SPAGGRTEQR HKVIATSTAT STIASVSTTA PSASSSSEIR NAAATATMSP
EQEASPPPAA PGASPSPPPS TTLPSPAISQ SQEEQHGGGN SDVEQFSGKI VYNPDGSAYI
IEDSESESES ASVNVPEVVP PLQAVYVSRL LRQATRQPAE QPAVHSYRVI ALRDARPPRP
TSVPVKPILM CFVCKLSFGF ARSFANHAQS EHGVHLQDAE REILSADCSA ILQCVGADKK
PIVSLLEPFG TSSSQQVSDN HMCSVPVPVS RSEQMSPSSE ITPVSSRNTP GKSPSPPFAP
PPAFLSGTTI GVCPEHLQGR PSGVDCPRCE MILASGRLGP AGLGNVHSRN SCKTLKCPKC
NWHYKYQETL EIHMKEKHPE TETSCIYCIA GQPHPRLARG ETYTCGYKPY RCEVCNYSTT
TKGNLSIHMQ SDKHLNNMQE LQNGGAPNTE SRQASPKAPS LHHSPVSSGH KPKPSFRCDV
CNYETNVARN LRIHMTSEKH THNMLVLQQN VKHMQTLSAI HHQQQSQHME NLYGIYPGLG
DKPEAALADM AYNQALLIQM MTGGQLPGHA GPADMTSHSD LGLNPETMEP PPEPAELDPQ
KTFHCCVCNL FSTDSLEDLG RHLAQDRTRL REQEILAVIA GHYVCKLCTY KTNLKANFQL
HCKTDKHLQR LQHVNHVKEG GLRNEWKLKY ASAPGGVQIR CNACDYYTNS AHKLQLHSAG
SRHEAGVALL RFLEERSSPL RPDQPRVFHC NLCGFSAANR LPLLQHIKSL KHLHLEQLHQ
IQRRAEGKDA PAEMSEVFQV VPAPFEQRQQ RTPERRDSTN SSDLKQEQSN ESLKTEPLED
VEELNASQTT ESDSPVQMCP YCNYTSDSEM RIQAHIIAQH SENSSSSEVV VYHCPLCQDQ
FKDRPVLERH VMQIHSVNSE GLQRLLMLVD QSHWLNQVSR TSTPNQTGNN QIQTPPNQMI
SPNSVASKDS NKLDKGDVNM DDVQEVLSPN SDENTDPEVE KCGTCSKNFK NIDELCCHQN
ETGHLEIKQT PSGPGYMCWK KGCNQFFPTA HTLQMHFREV HAKNSITQMS VSEKHVYKYR
CNQCSLAFKT LEKLQLHSQY HLIRDATKCV LCGRSFRSVV ALHKHVESVH SELTDEELIA
YKQSLMNNPL LLAGLQGQVL DSSTNDILRK ESLRNDEIEP LDCDDSKELN TSQEDNNQND
GENSDDSIVY KDQQFLEDYL NSQAMAEDSY NDPNRKYKCH RCKVAFTRQN YLTAHNKTLL
HRKGEKLSYP MEKYLDPNRP YKCDVCKESF TQKNILLVHY NSVSHLHKLK RAMQEQQQQN
NNNNQPVSPI ISSQTQNLSL TPKSTSSDED DKKRYKCNIC KVAYTQGSTL DIHMRSVLHQ
TRASKLQDLA LSGQIDLSKP LIEQPEAMQS PHQTSPAPCI GGSGGEKLSP TPPSPGTGSQ
QQQQQGMMSC SKCGALFAST DQLCTHQQQC CTNTFAAPMA IFQASQEPGQ AKSPPPPSMS
SEGQHQQELL NRLNLPKKSG SYMYKQLLES FGFDLVMQYN ESHQRRQRQL NEEKQLSSSG
SCISPPSSSS IHGDVVAIEP TAAAGAKSEE EPSTDNNASG LPEVSRSTCQ HCNKEFSSVW
VLKSHCEEVH KDLVPLEFLE KYAQQFKTEY EKKSVVVTAA TSSTTHVPTT TSVGGEDPDP
EKDGDDNIKE STTTTSTIPS AEAGAVTTTA PSTPTSSTTP SASSTDSASV PSNIQAIIAQ
SMAQNPMALA QQMSEMQAAL NVMQLQQQLN FNPMMQMMGM GLPLGLNALA AMNLQPPLVP
LMMPPPPYDP ISQFAPQDQQ AMLAKQQVMM QQQVAVSAAA NQKRARTRIT DEQLKILRSH
FDINNSPSEE QIQEMAIQSG LPPKVIKHWF RNTLFKERQR NKDSPYNFNN PPSTTLNLEE
YEKTGEAKVM PLNSSGSSTD DGGKQDNLQQ PTQIKMEVKE EPAEDIHKYM DEKLHHSNEY
EDKTHIFNLP PHSQSPISYV TTSDPQNYTQ TSNSQNSFNL TSVIASQFSD VITTTSAPLS
ITPNTSTSTS PMLPPTKMNQ SNFSTPNSFQ NILPLSGNRC LSPNRGDYNP GGSVCSAGSS
TGKRANRTRF TDYQIKVLQE FFENNAYPKD DDLEYLSKLL NLSPRVIVVW FQNARQKARK
VYENQPAIEP SPGITTDEAG ANRFQRTPGL NYQCKKCLLV FQRYYELIRH QKTHCFKEED
AKRSAQAQAA AAQIAAVLSS EDSNSSTIVE QSQQQQQQQQ PQQQQQQQQQ QQPPPPPQQQ
QHNQQQSSLP MTSQSQNNPH SPMQTTNIPI TPNNSGSNFP TSPTSTPQPP DCKEGSFQCD
KCNLVFPRFD LWREHQIVHI MNPNLFPSYP PDSPFGILQQ HAQLQQLNAA NINDLNNTAS
ALQHPIMNMI NSVVGQKRKF DEDSESDVSD QPKDKRLRTT ILPEQLDYLY QKYQIESNPS
RKMLENIARE VGLKKRVVQV WFQNTRARER KGQFRAHAQV INKRCPFCPA LFKVKSALES
HLTAKHSDQC ARGEINIDAI PDEEVSLESS PNFNPNVDTK SQQSQNAAIM PQLFPPLNSD
IENSIKKYYE ESMKRYISEL QAHATASTNG DRSEVKTGKE ETGETPLDLS KPVDLSRPMK
VNMDHERSMC DPGPLTDLSE RSLCDERSDS MSETTEFFDD ESNPTSPASS TQSNQQQRQH
QNNSASKRFR TQMSSLQVKV MKSLFSDYKT PTMAECEMLG REIGLPKRVV QVWFQNARAK
EKKNKLALQK VLGGSDVDTT KTPEECRVCS FKYSHKFSIQ DHIFTKGHIA NVRLHLENTS
KDGSGSDGEF TVPPIPGVSG NVPADSTTNV APSSQNVNNN SHMQLLQMAS MQMAAASKGE
KDSQESLFQQ LYSLGSNNSY SMQNQLLQTS LFGTNGS
//
