GenomeNet

Database: UniProt
Entry: A0A1W4X8M9_AGRPL
LinkDB: A0A1W4X8M9_AGRPL
Original site: A0A1W4X8M9_AGRPL 
ID   A0A1W4X8M9_AGRPL        Unreviewed;      2287 AA.
AC   A0A1W4X8M9;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   08-MAY-2019, entry version 11.
DE   SubName: Full=acetyl-CoA carboxylase isoform X4 {ECO:0000313|RefSeq:XP_018332456.1};
GN   Name=LOC108741969 {ECO:0000313|RefSeq:XP_018332456.1};
OS   Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga;
OC   Elateriformia; Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX   NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018332456.1};
RN   [1] {ECO:0000313|RefSeq:XP_018332456.1}
RP   IDENTIFICATION.
RC   TISSUE=Entire body {ECO:0000313|RefSeq:XP_018332456.1};
RG   RefSeq;
RL   Submitted (APR-2017) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=biotin; Xref=ChEBI:CHEBI:57586;
CC         Evidence={ECO:0000256|SAAS:SAAS00197451};
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DR   RefSeq; XP_018332456.1; XM_018476954.1.
DR   GeneID; 108741969; -.
DR   Proteomes; UP000192223; Genome assembly.
DR   GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   InterPro; IPR034733; AcCoA_carboxyl.
DR   InterPro; IPR013537; AcCoA_COase_cen.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR005481; BC-like_N.
DR   InterPro; IPR001882; Biotin_BS.
DR   InterPro; IPR011764; Biotin_carboxylation_dom.
DR   InterPro; IPR005482; Biotin_COase_C.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR011763; COA_CT_C.
DR   InterPro; IPR011762; COA_CT_N.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF08326; ACC_central; 1.
DR   Pfam; PF02785; Biotin_carb_C; 1.
DR   Pfam; PF00289; Biotin_carb_N; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF01039; Carboxyl_trans; 1.
DR   Pfam; PF02786; CPSase_L_D2; 1.
DR   SMART; SM00878; Biotin_carb_C; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52096; SSF52096; 2.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS50979; BC; 1.
DR   PROSITE; PS00188; BIOTIN; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS50989; COA_CT_CTER; 1.
DR   PROSITE; PS50980; COA_CT_NTER; 1.
DR   PROSITE; PS00866; CPSASE_1; 1.
DR   PROSITE; PS00867; CPSASE_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|SAAS:SAAS00234148};
KW   Biotin {ECO:0000256|SAAS:SAAS00296904};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000192223};
KW   Ligase {ECO:0000256|SAAS:SAAS00232059};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|SAAS:SAAS00234082};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192223}.
FT   DOMAIN       44    540       Biotin carboxylation.
FT                                {ECO:0000259|PROSITE:PS50979}.
FT   DOMAIN      193    388       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
FT   DOMAIN      667    741       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN     1497   1836       CoA carboxyltransferase N-terminal.
FT                                {ECO:0000259|PROSITE:PS50980}.
FT   DOMAIN     1840   2173       CoA carboxyltransferase C-terminal.
FT                                {ECO:0000259|PROSITE:PS50989}.
FT   COILED     1118   1138       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2287 AA;  258879 MW;  3031F00FFC565AFC CRC64;
     MWKEETKRPS MSQGTVMLHN RPYEKDFTVA TPEEFVRRFN GTKVINKVLI ANNGIAAVKC
     MRSVRRWSYE MFKNERAVRF VVMVTPEDLK ANAEYIKMAD HYVPVPGGTN NHNYANVELI
     VDIAIRCQVQ AVWAGWGHAS ENPKLPELLH KNDIAFIGPP EKAMWALGDK IASSIVAQTA
     DIPTLPWSGS DLKAQYTGKR IKISSDLFSK GCVHSAEQGL AACQKIGFPV MIKASEGGGG
     KGIRKVESAD DFPSAFRQVQ AEVPGSPIFV MKLAKCARHL EVQLLADQYG NAISLFGRDC
     SIQRRHQKII EEAPAVIAKP EIFEEMEKAA VRLAKMVGYI SAGTVEYLYD VSGKYYFLEL
     NPRLQVEHPC TEMVSDVNLP AAQLQIAMGL PLHYIKDIRM LYGESPWGTF EIDFDAPLHK
     PEPWGHVIAA RITSENPDEG FKPSSGTVQE LNFRSSKNVW GYFSVAASGG LHEFADSQFG
     HCFSWGENRE QARENLVIAL KELSIRGDFR TTVEYLITLL ETKDFQENTI DTAWLDILIS
     EHVQAEKPDV MLAVMCGSLH IAEKTINNAF TEFQNSLEKG QIQGSNALTN VVDVELIHEG
     NKYKVQTTKS GPNTYFLVLN GSFKEIEVHR LSDGGILLSV DGASFTTYMK EEVDRYRIVI
     GNQTCVFEKE NDPTILRSPS AGKLIGYLVE DGGHVDKGQT YAEIEVMKMV MTLTATESGS
     IFFCKRPGAV LDAGSVIATL ELDDPSLVTK AQLYKGPFPE LDVSTPVHSN KLNHIHNTYK
     SALESILAGY CLPDPYNVPR LREIIEKFMS SLRDPSLPLL ELQEVMASIS GRIPAAVEKK
     IRRLMSLYER NITSVLAQFP SQQIASVIDS HAASMQKRAE RDGFFLATEG IVHLVQRYRN
     GIRGRMKAAI QDLLKQYYEV ESQFQQGSYD KCVATLREKN KDDMAVVLAT IFSHSQVAKK
     NLLVAMFLDH LWSKEPGLTE ELATTLNELT SLNKSEHSRV ALRARQILIA AHQPAYELRH
     NQMESIFLSA VDMYGHEFHP ENLQKLIASE TAIFDILHDF FYHANRAVCH AALEVYVRRA
     YTSYDLNCLQ HLELSTETPV VHFQFVLPPS HPNRLSRLDT LRDQLKSQEE EGTDLTKLAH
     DTFQRTGCII AFNTIQEFEE ATDEILDLLE DCASPAAISA KDLSMLESGS ESRGNSTSIN
     VSISVAESGR QKDEEEITEP NHILQVCIKD KGDTNDSSMS RMFGSYCAKH REELESRGIR
     RITFAVLKNK QYPKYFTYRH RDGYKEDRIY RHLEPASAYE LELDRMRTYN LEALPTSNQK
     MHLYLGKAKV APGQEVTDYR FFIRSIIRHP DLITKEASFE YLQNEGERAL LEAMDELEVA
     FSHPQSRRTD CNHIFLNFMP TVIMDPTKIE EAVTNMVMRY GPRLWKLRVL QAELKMPIRI
     NPNAPLQSLR LTLANDSGYY LDINMYTEIL DPEAGIMRFQ AYGTKQGPMH GLPTTTPYLA
     KDYLQQKRFQ AQSSGTTYVY DYIDMFRQMI DSHWKLYSEK RNEAVKTPDK QLDFVELVLD
     PETETRLVET KRIPGENNVG MVAWRLTLYT PEYPDGRDII VIANDITYQI GSFGPREDKV
     FGLASEVARQ LRIPRVYIAA NSGARIGLAE EVKKLFRVAW DDPNEPDKGF KYLYLTPEDY
     AKLSTLNSVR AVLIEDEGES RYKITDIIGK EDGLGVENLR YAGMIAGETS QAYNEVVTIS
     MVSCRAIGIG SYLVRLGQRV IQIENSHIIL TGYMALNKLL GREVYASNNQ LGGIQIMYNN
     GVTHKTEPTD IEGINTILKW LSFIPKDKMS PLPIINSLDP IDREVEYTPT KTPYDPRWML
     AGRENLSNPG EWESGFFDRD SFSEIMAPWA QTVVTGRARL GGIPVGVIAV ETRTVELKLP
     ADPANLDSEA KTVSQAGQVW FPDSAYKTAQ AIQDFSREDL PLIIFANWRG FSGGMKDMYE
     QVMKFGAYIV DGLRQYNQPI IIYIPPNGEL RGGAWAVVDP TINSRHMEMY ADPDSRGGVL
     EPEGIVEIKF RKKDLLKAIH RLDPEIVELN KKINEINKLQ PVERKSSITQ QVERPKNPEV
     LELEKKVAER EKILLPMYHQ VSVHFADLHD TPERMHEKGV INEVVPWRNS RKILYWRLRR
     RLLQNRVISS MTEIQPTIAV GQAESMLRRW FVEDKGPIES YKWENNESVV LWLEDQLSRP
     AEQSIIGYNL HCVSKDAALT KIQESLESCP DVALDAVVQI VQKLKDNQKA EVIRTLSLLQ
     DDQESPE
//
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