ID   A0A1W4XGN4_AGRPL        Unreviewed;       800 AA.
AC   A0A1W4XGN4;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=LOC108744053 {ECO:0000313|RefSeq:XP_018335154.1};
OS   Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC   Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX   NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018335154.1};
RN   [1] {ECO:0000313|RefSeq:XP_018335154.1}
RP   IDENTIFICATION.
RC   TISSUE=Entire body {ECO:0000313|RefSeq:XP_018335154.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   RefSeq; XP_018335154.1; XM_018479652.1.
DR   AlphaFoldDB; A0A1W4XGN4; -.
DR   EnsemblMetazoa; XM_018479652.1; XP_018335154.1; LOC108744053.
DR   GeneID; 108744053; -.
DR   KEGG; apln:108744053; -.
DR   InParanoid; A0A1W4XGN4; -.
DR   OrthoDB; 3176557at2759; -.
DR   Proteomes; UP000192223; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF84; ANOCTAMIN; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        233..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        313..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        385..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        432..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        605..626
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        656..679
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        691..710
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        751..775
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          20..219
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          223..788
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   800 AA;  94381 MW;  F368CD1A4B88E739 CRC64;
     MTTQYIILDN TEDYIPVSCC FRDKKRRIHL VIAVSAGNID EKLGVFVENL KSQGVHVEED
     FGVYDNEIKF IKLHLPDDKA AAFAKAYQID CYYERRQFWT EQNPNSYLRK FFPFHETSVV
     VNERNPMYQK STFELNKSPT SITYSEVSYV LYKLLNETHF GDKQFEFGVD RLLNKKIALS
     IYSLHEGQWQ WTVEGGVSSR QILAKYWSNS KMCYKQQPMN SVTRYFGTEV AHFFGLLGFY
     IKMVFPLAIA GILCVIWGVS SINTIENQAS LDVCKSDIVL CPRCDNNKCR YKWLHSACFN
     MHLTYLVDNA GSFVYGLFVL FWAVIFHRLW LRRKNTYTFL WNVDKEIDIA IRLEYEKKAR
     SKRTSYFTGL EEPHMPVKEK LARLALSWST LFLLVFSILS TLILSAMMRV WFELYFNQLG
     SKHELYIMES NRFYAMIINS STSSLCVILM TEFYRYLSSI LTEFETPRTK TEFGYSYIVK
     LYVLEFANHY GSLFYIAFVK GRLYTHPGDQ SSNPITYILR NDHCTIPGCL NDLNVNLLVR
     IWFFIGRSFL KPIIRRLVNC FRFKCRPKTI PFDTLPQWEA DYYMTKVPDT YLINRQLKIV
     IIHGYMTLFA LVSPLAPLFI LIYALMELRL EAKQYIKNYR RPILTKITTS TVFSDLFMLT
     AYIGVVTNAC ILAFTTSFVE REVYRYSDNS SLYGFFYSTL SVFNATQYNL DQRMALVPIP
     TNLTECYYQG KRYPPEHARQ YQRREHFWIE YFYKFLVVIV VEHLVLIVIT ILEVVSSPIP
     YHVKQRMRLE WIQKKERQRT
//