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Database: UniProt
Entry: A0A1W4XHU8_AGRPL
LinkDB: A0A1W4XHU8_AGRPL
Original site: A0A1W4XHU8_AGRPL 
ID   A0A1W4XHU8_AGRPL        Unreviewed;       378 AA.
AC   A0A1W4XHU8;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Calcitonin gene-related peptide type 1 receptor-like isoform X2 {ECO:0000313|RefSeq:XP_018335559.1};
GN   Name=LOC108744348 {ECO:0000313|RefSeq:XP_018335559.1};
OS   Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC   Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX   NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018335559.1};
RN   [1] {ECO:0000313|RefSeq:XP_018335559.1}
RP   IDENTIFICATION.
RC   TISSUE=Entire body {ECO:0000313|RefSeq:XP_018335559.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000256|ARBA:ARBA00005314}.
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DR   RefSeq; XP_018335559.1; XM_018480057.1.
DR   AlphaFoldDB; A0A1W4XHU8; -.
DR   EnsemblMetazoa; XM_018480057.1; XP_018335559.1; LOC108744348.
DR   GeneID; 108744348; -.
DR   OrthoDB; 5345963at2759; -.
DR   Proteomes; UP000192223; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   CDD; cd15260; 7tmB1_NPR_B4_insect-like; 1.
DR   Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   PANTHER; PTHR45620:SF32; DIURETIC HORMONE 31 RECEPTOR, ISOFORM C; 1.
DR   PANTHER; PTHR45620; PDF RECEPTOR-LIKE PROTEIN-RELATED; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF02793; HRM; 1.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   SUPFAM; SSF111418; Hormone receptor domain; 1.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170,
KW   ECO:0000313|RefSeq:XP_018335559.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        76..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        111..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        187..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        226..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        308..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          21..66
FT                   /note="G-protein coupled receptors family 2 profile 1"
FT                   /evidence="ECO:0000259|PROSITE:PS50227"
FT   DOMAIN          74..331
FT                   /note="G-protein coupled receptors family 2 profile 2"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
SQ   SEQUENCE   378 AA;  43450 MW;  C77D0829EBA95FD0 CRC64;
     MSAQPSELSL AEIIRSKEEH CNSTLNSTDI RTDGIAYRKC EENGDWFVHP IYNKTWSNYT
     TCVNLEELSF RQQINIVYSV GYSISLVALV ISLAILTYFK SLRCARITVH MNLFASFAMN
     NLLWLMWYNI VIGNPDVVST NKWWCRILHI VLYCFLLSNY TWMLCEGVYL HTVLVSAFIS
     ESRLLKYMYL LGWGVPGLTI VIYAFTRHFD GEATDTSECW MNDGKYNIIL QVPVCAAVCL
     NVIFLINIVR VLLIKLRNGP HLQRNNSGST RTSIQALRAT LLLVPLLGLN FLLTPFRPEE
     KHPWEHAYEI LLAITASLQG FCVAILFCFC NGEVMAQIKR KWSLVMFRPR ANSCTVTTVS
     VRKVDIFYFN FYLFLTLS
//
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