ID A0A1W4XLI2_AGRPL Unreviewed; 1116 AA.
AC A0A1W4XLI2;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=non-specific protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011903};
DE EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903};
GN Name=LOC108742563 {ECO:0000313|RefSeq:XP_018333328.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018333328.1};
RN [1] {ECO:0000313|RefSeq:XP_018333328.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018333328.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001149};
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DR RefSeq; XP_018333328.1; XM_018477826.2.
DR AlphaFoldDB; A0A1W4XLI2; -.
DR STRING; 224129.A0A1W4XLI2; -.
DR EnsemblMetazoa; XM_018477826.2; XP_018333328.1; LOC108742563.
DR GeneID; 108742563; -.
DR KEGG; apln:108742563; -.
DR InParanoid; A0A1W4XLI2; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0065008; P:regulation of biological quality; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR041155; FERM_F1.
DR InterPro; IPR041381; JAK1-3/TYK2_PHL_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
DR PANTHER; PTHR45807; TYROSINE-PROTEIN KINASE HOPSCOTCH; 1.
DR PANTHER; PTHR45807:SF7; TYROSINE-PROTEIN KINASE HOPSCOTCH; 1.
DR Pfam; PF18379; FERM_F1; 1.
DR Pfam; PF17887; Jak1_Phl; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR PRINTS; PR01823; JANUSKINASE.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM00219; TyrKc; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_018333328.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT DOMAIN 4..300
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 461..716
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 841..1109
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 877
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1116 AA; 127900 MW; 160596CEDBFABC38 CRC64;
MGEPALSVNL VLDKKVMSIS YSATTTAEDV CTTVCKKLSI GPVARHLFAL RVKDKQIFLM
PSATFTEKNP SYDLRIRFKP ASLDKLKKID INAYNYYFHQ ARNDLLENKI PDIVFDKCRR
ELVGLGVTDM YRVMLEKDIT KEIVENDYRK YMPKEVIKRH SFFVKKPVKD TLEKIRRSGH
DAWYVKSEYL KQLDNIAPEY LCEEYKALND RDGSIYSVFV RVSPYHPTDP GIRICLESRK
DQWEQICKIE DLCHISIRKD GTVEISRKNG IPFYLQFALP LMYSFVSLLD GYYRLTCKWT
FNLCKDVTTP SLKSLYSMRC HGPVGGEFSY SKLEEKRGNH PGCFILRECE TRYNVYFIDV
CIKNCSKPKT YKLEKLPNNE LIFNDDLTKY KNVFQLIKAY SDPNGSIFLQ ECLPPSEYDN
SHLLLCQNET LVGDSLTDGS SVKGLIPSSP LCINNRDIQV YKGHKKLGSE ERTMVYRSMW
KLTKGKKIEV AMKILKHEYY EEYLKEFLEL AGQWAFLQSY AIVKLFGVTL TSPVSMVLEY
MKLGNLDQYL QRNKSSLKEV DLIEAATNLA SALWHLEENG IVHGKIRCKK LLVSYHDDRV
FTVKLSDPGV RYSYSSNEVH WIPVECYSNL EFAKRSTAAD VWAFATTLWE IFMYGEQIKQ
TSHINAMKFY ASGKRLPQPA SCPNDIYQIM KECWDADPHR RKQPQAIMRD IKQIFYQVFN
SRRVHSYAKV FTSKMSKSSG SVSSLNTNAT DSTYVLPNDG LVSLSSMSEK DIDFMYGSST
NGISVEKAWI LGNLDYSDDT ESCDVSTILS NFDFSAATSA TSLNSLNSMQ SVFELDGDCN
VVLQGRIGQG FYGEVYKGTL EYLGDKDIEA KQVAVKKLKT SAVSTCLQDF EREITIMKNL
KHPNIVEIFG VLQEPEISLV MEYVPHGSLQ SYLKIYKEVL TVKQLLKYAL DIANGMEYLG
TKHNIVHRDL AARNILVVDE NHVKISDFGL AQVMGPNDYY ILKTSRELPI KWYALESLRD
GKFSSRSDVW SFGVTLCEMF SYGEEPKLPN VEVTPAEQEQ QALLNSLENG ARFPCPPMCP
QSVYVRIIYP CWTNSPHDRP TFSLLHGEIQ DMLTQY
//
