ID A0A1W4XPM1_AGRPL Unreviewed; 1051 AA.
AC A0A1W4XPM1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN Name=LOC108743308 {ECO:0000313|RefSeq:XP_018334340.1};
OS Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia;
OC Buprestoidea; Buprestidae; Agrilinae; Agrilus.
OX NCBI_TaxID=224129 {ECO:0000313|Proteomes:UP000192223, ECO:0000313|RefSeq:XP_018334340.1};
RN [1] {ECO:0000313|RefSeq:XP_018334340.1}
RP IDENTIFICATION.
RC TISSUE=Entire body {ECO:0000313|RefSeq:XP_018334340.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_018334340.1; XM_018478838.2.
DR AlphaFoldDB; A0A1W4XPM1; -.
DR STRING; 224129.A0A1W4XPM1; -.
DR EnsemblMetazoa; XM_018478838.2; XP_018334340.1; LOC108743308.
DR GeneID; 108743308; -.
DR KEGG; apln:108743308; -.
DR InParanoid; A0A1W4XPM1; -.
DR OrthoDB; 5477697at2759; -.
DR Proteomes; UP000192223; Unplaced.
DR GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:1902975; P:mitotic DNA replication initiation; IEA:InterPro.
DR CDD; cd05776; DNA_polB_alpha_exo; 1.
DR CDD; cd05532; POLBc_alpha; 1.
DR Gene3D; 2.40.50.730; -; 1.
DR Gene3D; 3.30.70.2820; -; 1.
DR Gene3D; 1.10.3200.20; DNA Polymerase alpha, zinc finger; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR038256; Pol_alpha_znc_sf.
DR InterPro; IPR045846; POLBc_alpha.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR015088; Znf_DNA-dir_DNA_pol_B_alpha.
DR NCBIfam; TIGR00592; pol2; 1.
DR PANTHER; PTHR45861; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45861:SF1; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF08996; zf-DNA_Pol; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000192223};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 97..383
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 452..877
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 913..1045
FT /note="Zinc finger DNA-directed DNA polymerase family B
FT alpha"
FT /evidence="ECO:0000259|Pfam:PF08996"
SQ SEQUENCE 1051 AA; 121989 MW; 15E427B761F5C1CC CRC64;
MKESGGNNVS MLPLVLNEDG KKIFRFYWWD GFEDKNRPGL VLLFGKVYSE ESSSYISCCV
SLTEMHRKIY LLPRPRHKET QKEITLVDVN QEFNDTISKE LNISSFRSKE VLKNYCFDPE
VPAKSKYLEV RYSAKYPALD SKRSGKTFSR VFGTNSSFLE IFLLECKIKG PCWLDVTNPE
LVPNRMSWCK FEVNCKMSDI SVAKNSNDIP PPPLVVAAIN MKTVVSPKHF RDEIVVISCY
VNNEYYVNKQ APNVPFQKHF CALTTPEGQM FPIDFYENVQ NYKDTKIQKL DSERSLINYF
INQFSKLDPD LIVGHDLLGY QITILCQRLL EHRVNTFSKF SRIKRNILYK EKNEQLLFTG
RLVCDIKVSA KELIKSRSFD LLTLSENVLK INENERVEID PTDIPKYYED YSNLLKLVSV
AMQDTLFILN IMYELNVIPL TLEITNITGN LLSRTLMGGR SERNEFLLLH AFYENDYIVP
DKYELTKNKY EIERVRFGKK PAYSGGLVLD PKVGFYDRLI LLMDFSSLYP SIIQEYNICF
TTVLDTQGED VVLPDKQLPP GILPKEIRKL VESRREVKKL LNNLDISNNL RVQYSIREKA
LKLTANSIYG YLGFSNSRFY AKKLAALITY KGREILTSTR DVVTKMALEV IYGDTDSIMV
NTNCLDYGQV MQIGVKIKQE VNKLYHQIEL DIDSVFKYLL LLKKKKYAAV TLTKSTSGQL
VTAQEYKGLD LVRRDWSQLA AEASKFILNC IFKNCSLDER IKNIQVHLRK LREDLEHGKV
PLRLLIITKQ LNKDPKMYAD NLQLPHVKVA HRYNKKGGKL LKAGDTVSYV ICEDGTGNSH
VQRAYHVDEL KNNELKIDVK YYLAQQIHPV VTRLCEPLEE IDAYELATCL GLDNTSLKKA
KNNNHMYNNV WSKEIVFKNV QFFSFKCISC KSVNVVKDAH KTSFLEKCTN LNCSVRPVDY
LTSVQNQLIR NIRMYIAKYH ENKFKCEDLS CLRETIDISL RSVYKYPICL PCEVKEIHRN
YSEEDLHTQL LYYHHLFDLN KHESKYVQIY N
//
