ID A0A1W5CVG3_9LECA Unreviewed; 491 AA.
AC A0A1W5CVG3;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Autophagic Serine protease alp2 {ECO:0000313|EMBL:KAA6413801.1, ECO:0000313|EMBL:SLM34816.1};
GN ORFNames=FRX48_02162 {ECO:0000313|EMBL:KAA6413801.1};
OS Lasallia pustulata.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Lecanoromycetes;
OC OSLEUM clade; Umbilicariomycetidae; Umbilicariales; Umbilicariaceae;
OC Lasallia.
OX NCBI_TaxID=136370 {ECO:0000313|EMBL:SLM34816.1, ECO:0000313|Proteomes:UP000192927};
RN [1] {ECO:0000313|EMBL:SLM34816.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000192927}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sharma R., Thines M.;
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAA6413801.1, ECO:0000313|Proteomes:UP000324767}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A1-1 {ECO:0000313|EMBL:KAA6413801.1};
RA Greshake Tzovaras B., Segers F., Bicker A., Dal Grande F., Otte J.,
RA Hankeln T., Schmitt I., Ebersberger I.;
RT "The hologenome of the rock-dwelling lichen Lasallia pustulata.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; VXIT01000003; KAA6413801.1; -; Genomic_DNA.
DR EMBL; FWEW01000417; SLM34816.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W5CVG3; -.
DR OrthoDB; 380531at2759; -.
DR Proteomes; UP000192927; Unassembled WGS sequence.
DR Proteomes; UP000324767; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..491
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036311527"
FT DOMAIN 44..138
FT /note="Inhibitor I9"
FT /evidence="ECO:0000259|Pfam:PF05922"
FT DOMAIN 175..427
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 184
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 216
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 383
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 491 AA; 52723 MW; 3B932307BA756D18 CRC64;
MKGLVAISLL PLLASASPMI GVDTIHNEAA PILSSSTSKE IPNSYMIVFK DHVSHSNAAV
HHEWVQSLHL ENEHSKTELR KRSQLPVSTD IFAGLKHTYN IAGKFLGYAG HFDEDVIERV
RRHPDVAFVE KDSEVHTMEE YETEKNAPWG LARVSHRDSL SFSTFNKYLY AADGGEGVDV
YVIDTGTNVE HVDFEGRAEW GKTIPANDED ADGNGHGTHC SGTIAGKKYG VAKKAHIKAV
KVLKSNGSGT MSDVVKGVEW AALSHENSVR AAKKGKGKKG FKGSAANMSL GGGKSVTLDI
SVNAAVDAGI HFAVAAGNDN TDSCKYSPAA AEKAVTVGAS TLADERAYFS NYGKCNDIFA
PGLNIQSTWI GSKYAVNTIS GTSMASPHVA GLLAYLLSLQ PSKDSAYAVA DVTPKQLKQN
LIAIATEGVL SDVPSNTANI LAWNGGGSSN YTEIVHKSTT NKKMVEEIEE FVEDEMKEIK
SYFDDLKKSV Q
//
