ID   A0A1W5D0U9_9LECA        Unreviewed;      1290 AA.
AC   A0A1W5D0U9;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:SLM36757.1};
OS   Lasallia pustulata.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Lecanoromycetes;
OC   OSLEUM clade; Umbilicariomycetidae; Umbilicariales; Umbilicariaceae;
OC   Lasallia.
OX   NCBI_TaxID=136370 {ECO:0000313|EMBL:SLM36757.1, ECO:0000313|Proteomes:UP000192927};
RN   [1] {ECO:0000313|Proteomes:UP000192927}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Sharma R., Thines M.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FWEW01001308; SLM36757.1; -; Genomic_DNA.
DR   OrthoDB; 2284953at2759; -.
DR   Proteomes; UP000192927; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR   PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00075; RNase_H; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Nucleotidyltransferase {ECO:0000313|EMBL:SLM36757.1};
KW   RNA-directed DNA polymerase {ECO:0000313|EMBL:SLM36757.1};
KW   Transferase {ECO:0000313|EMBL:SLM36757.1}.
FT   DOMAIN          486..761
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   DOMAIN          957..1112
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
SQ   SEQUENCE   1290 AA;  146265 MW;  1C95BAC1DE0A599B CRC64;
     MKSRPVMEAL INDEEIGGYD VLLIQEPPLS AYYTHVSHRS WHRYEPTFDE EGTRKRSLIY
     VNKRISTSAH RQVDCMHPDV TAIKVWTENN QMLLFSVYIP PVDYHHLYEV QSMQPTLDVI
     ESTIGTHAID AATPRRTVLV IAGDFNRHHP AWSDGPVYER VMVHAGDLIN FIHAHALQWC
     LAKGNATYWS HNRPGQRSTI DLTLTNEQQR LIQCKLHHDA FGSDHRATVS EWNMQVEQRP
     ETPAKKAYDR ADWPSMGTKI QAKLQHGGQI ESRQQLDEAV AELTNLVQQE IDKCVPTARP
     SPYAKRWFTP ELKVQQVEVN KARRRWQERC ASHGRADPVA AQLFTEMHSQ RREWTRTIEK
     AKASHWREFL DQASSRTVWK ATPYLERTDN YACIPALKVG DNEYADNAGK AQALLASFFP
     TTVPPNPEMI VAPDEIAWEP ITEWEVASAL NKAKKNTAPG RDGLPTLVWR ELWPYVSTRI
     TQVFSASVRL AYFPTQWKTA KIVVLRKPGK EDYTTPKAYR PISLLNTLGK LLEAVMARRL
     SYYAETYQLL PDTQFGGRPG RTTEQALLVL VNSVDQTILR DMTVTLIAFD LKGAFNNVHA
     HTLEARLQER RIPGPARKWI RSFMQERTAS VQFDGFETEV EPLPFAGLAQ GSPLSPILFA
     FYNADLVDQV VDTQGGASAY IDDYFRWRVG KSAEENLDKI QNEDIPRITA WAERTGACFV
     PEKTELIHLT RRRKDRGKGS ITIGGQTVKA SETAKLLGVI FDTEMRWKEH VQHATKKATV
     TALGMSGLRY LRPAQMRQIY QACVLPKLDY ASTVWHSPLR DKGLLRVLAS VQRAALLRII
     SAFRTVATQT LEVECHILPT HLRLQQRAQD VIARLCTLPQ DHPMTKVVER TKQRMKRKSG
     LRFPLAESMK TMNITELNGI EIIDPRPKAP WRGLPLEQVE IIQDRDQALA RVKDLAHEPR
     KIIFTDASAR DAQLGVGVVM LGPSPEQTKT LQVGVGPATK WNVHLAELMA IWYATKMIQD
     LETQIRLRGD IDATLTTTNE ATEYTIVSDS QSALKAIIKS AAKSGQTIVQ RVLDQVQSLN
     KWDVRVRLCW VPGHANNEGN EAADQLAKQA VSSTEDHDFR TPLSAYRKTV RQTIEKEWRD
     EWTASKNGKY LKKIDSGLPN KRALRLHGCL TRHETYLFTQ LRSDHSWLFT YGKKRKFVDH
     DKCACGAVET VVHVLVDCPL LRELRQALRR KVGDAFGSIA TLLGGRNGQG QVNNGRNDRN
     VVKAVLEFAD ASKRFKSRTS AVPSSGHSRL
//