ID   A0A1W5D187_9LECA        Unreviewed;      1228 AA.
AC   A0A1W5D187;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Ribonuclease H-like domain {ECO:0000313|EMBL:SLM36780.1};
OS   Lasallia pustulata.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Lecanoromycetes;
OC   OSLEUM clade; Umbilicariomycetidae; Umbilicariales; Umbilicariaceae;
OC   Lasallia.
OX   NCBI_TaxID=136370 {ECO:0000313|EMBL:SLM36780.1, ECO:0000313|Proteomes:UP000192927};
RN   [1] {ECO:0000313|Proteomes:UP000192927}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Sharma R., Thines M.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FWEW01001326; SLM36780.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W5D187; -.
DR   OrthoDB; 1615197at2759; -.
DR   Proteomes; UP000192927; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR   PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00075; RNase_H; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
FT   DOMAIN          302..577
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   DOMAIN          804..945
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
SQ   SEQUENCE   1228 AA;  140204 MW;  D5274C0ADA6E3D38 CRC64;
     MANRQYTSVL DLALTTGQLA AEIIDWQINE NEYSGSDHEV IQFSITTEDI ELVESPFNAP
     FNIQKANWAE FNQQLVQESQ PMLTELRQLE TQDLNQEQME TIACSLRDLI TKAAEQNIPR
     RKPCSRSKVW WNPNLTLLQK EMAKQSRVYK RHDQSQQQWT KFASCRAEYF YAIKTAKRNS
     WTKFLSEANG KEVFQAYKYT KPRLMEKIPP IQTADGKLCH TFNDKCQTFV KAMYPKPPEI
     NQNPDRPNAP EAQWSSLTNN EVKQAIFTSS PKKAAGPDEI GFAIIQEAYK AIAEVMNLTY
     KILIRNGFHP QCWREGTGVI LKKAGKPDYS LPKAYRIITL LNCLGKVAEK IMATRLSYLS
     QISDLLDTDQ TGGRKQRSAV DAVMALTHDI ELARNQKQTL SCLFLDVKGA FDHVSTKQLL
     RIMSELQLPR QVQNWTKSFL RKRKAGLAFD GEKQRIQRIE IGIPQGSPIS PVLFLIYIRF
     LFPKIKAKFP EVQKPSYIDD VALYTTGRNA EENAKVLQEV TKTVFTWAEE NAVQFDDSKT
     ELIHFARGQK EATAEVTLPN KTVIKPVNEV KWLGIWLDRK LTYKTHVQKK ASAATSVLHL
     IHRLMNSEWG LSAQAGKQLY TACITSISDY GAEIWWKNQR SYQDLLQKLQ NTALRKILGA
     FRTSPGAAME IEASIEPVKV RLNKKCRKYA LRVTTLPENH CIRQRIPMSY PPESSIGQEV
     PIQGNYLDWN QNAQRKSQRH PTQLIRILNS ISTLIPTGTK LDSQSAANPP WQDTFAELAD
     LSISGEDRDL VVKKHLTHIR QLIDQNHPIF YTDGSKLESN VNSQAKASLG AGIYWIFGKV
     TSSESHFLGH TQEIMDAEIY AISQALERIT DTKTRKKHFW VFTDSQSAIQ NLQKDQMETE
     VYRDMRQNLE QIKAQGRKVH IHWIPSHTFI PGNELADMAA KKGARNADPE IINSARTSIS
     RSFIKRDIAK IAREEWTQYW KTTNQGQQYS KFQTSLELKM KSKELEQADR LTFTTFTQIK
     LGHGYFKSYL TALPVLSGRL FCLGILEDDR EWVSCFTEAV LFTSGAALRT LLVTSLVHGG
     VTNPNSLWNR FHASICDDLP HCLQLFAGVP VEFEDPYYDY GLFLINALLT DFDKTLASYQ
     LPQYTLDWGR LQGNPLIQAE LQYAPDTEQA LRDEKYQQFN ADQQQAFNTI VAAIEQDPAG
     VHFLFTGPCR YWKDLSISVP LSSFPRKG
//