ID A0A1W5DDS7_9LECA Unreviewed; 863 AA.
AC A0A1W5DDS7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Nonsense-mediated mRNA decay factor {ECO:0000256|RuleBase:RU369098};
OS Lasallia pustulata.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Lecanoromycetes;
OC OSLEUM clade; Umbilicariomycetidae; Umbilicariales; Umbilicariaceae;
OC Lasallia.
OX NCBI_TaxID=136370 {ECO:0000313|EMBL:SLM41298.1, ECO:0000313|Proteomes:UP000192927};
RN [1] {ECO:0000313|Proteomes:UP000192927}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sharma R., Thines M.;
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in nonsense-mediated mRNA decay.
CC {ECO:0000256|RuleBase:RU369098}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369098}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FWEW01003821; SLM41298.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W5DDS7; -.
DR OrthoDB; 1356823at2759; -.
DR Proteomes; UP000192927; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR InterPro; IPR019458; Est1-like_N.
DR InterPro; IPR045153; Est1/Ebs1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR15696:SF0; PINC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR Pfam; PF10374; EST1; 1.
DR Pfam; PF10373; EST1_DNA_bind; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Nonsense-mediated mRNA decay {ECO:0000256|RuleBase:RU369098};
KW Nucleus {ECO:0000256|RuleBase:RU369098}.
FT DOMAIN 56..174
FT /note="Telomerase activating protein Est1-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10374"
FT DOMAIN 186..477
FT /note="DNA/RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF10373"
FT REGION 656..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 863 AA; 96038 MW; E2A537C23C4D1292 CRC64;
MAVSNEQAWT FTQRAERKLQ ATLLEKDPTF RDIDHFLTQQ CEDLIFRHFD FATWENVEAR
LWDAHIKVNN RFRKQLGRFR EGDGKKRPVE QRKVTKHYLE FIKSSQRFYR GYIQRLASYF
GGIPEVEAVA HQFHVSEQPA HNQAEVSAEV RQAILISCHH TLVRLGDLSR YRETELVTKE
RNWGPAIGYY DLAGAIYPTS GVSHNQLAVI ALADGNHLRA TYHLYRALAV EEPPPTAKGN
LEIEFKKISA AWSKGELIAQ GVQKDGQGPG QALVGWFMRL HARCYRGVEF SEHDELENEV
LSQLAIDLKE RSLEGTLNKF VLINIAAEYF AGVRLQEDPA SQESMQAFFF FQRLNVSTFF
ALLQVLQPEL ERFAVDEEVI NDASPRTTNG SDRITAVARR VLPGLRHYSS WLISNTAFLL
AQVGDTSLTV QIKEMWKIYA HTLTLLAATF PVSALPCVDY LLEEDEDTLG FKPFNNDRTK
RRYFSSDEEK PKLKWHDSGV ERQHPNIEML GRSIPMDLAE CTITFTFREE GVPSELLASP
GLAPTLSSTS IELQGIPEIS DTTAPDKVSI ADDGASQSAT ASVSMNPAMR RMVDNLVDEA
EEMGSMDDHR IINGPQELTP PNAILDDWIF HAPGNDTSYG TIGTLTAQTL LQDVPNSSSA
QQRYSTPGPI LPSIYNTPFA PLPSDATPSP QSRPSTAKRM QGHSKQNSGN FSPLQPLPNG
WSLHSSNISS MPDPSSMIFP HAPTNGQSTT FPRHLGNGTF GGGNAFMSSA VFNDSPWISG
SARDDTDTQM DYQDDKAATA NSGRNDGTSK RGSNAVNNGL RTCKRCKADV FRSNNELHKH
LKACKGRGRG RNVHATLPNG QGG
//
