GenomeNet

Database: UniProt
Entry: A0A1W6B5H4_9GAMM
LinkDB: A0A1W6B5H4_9GAMM
Original site: A0A1W6B5H4_9GAMM 
ID   A0A1W6B5H4_9GAMM        Unreviewed;       646 AA.
AC   A0A1W6B5H4;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN   ORFNames=B1H58_09930 {ECO:0000313|EMBL:ARJ42299.1};
OS   Pantoea alhagi.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Pantoea.
OX   NCBI_TaxID=1891675 {ECO:0000313|EMBL:ARJ42299.1, ECO:0000313|Proteomes:UP000192900};
RN   [1] {ECO:0000313|EMBL:ARJ42299.1, ECO:0000313|Proteomes:UP000192900}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LTYR-11Z {ECO:0000313|EMBL:ARJ42299.1,
RC   ECO:0000313|Proteomes:UP000192900};
RA   Zhang L.;
RT   "Complete genome sequence of the drought resistance-promoting endophyte
RT   Pantoea alhagi LTYR-11Z.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP019706; ARJ42299.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W6B5H4; -.
DR   STRING; 1891675.B1H58_09930; -.
DR   KEGG; palh:B1H58_09930; -.
DR   OrthoDB; 9763467at2; -.
DR   Proteomes; UP000192900; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03482; MutL_Trans_MutL; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00149};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000192900}.
FT   DOMAIN          212..330
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          469..600
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
FT   REGION          338..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          440..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   646 AA;  70772 MW;  61E328EC8490C3BA CRC64;
     MPIQILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIEKGG AKLIRIRDNG
     CGIDKEELAM ALARHATSKI TSLDDLEAIM SLGFRGEALA SISSVSRLTL TSRTADQNEA
     WQAYAEGRDM TVTVKPAAHP VGTTLEVLDL FYNTPARRKF LRTEKTEFTH IDEVVRRIAL
     ARFDIAISLT HNGKLVRQYR AATQESQQLR RLGAICGATF MEHALKIEWQ HDDLILRGWV
     ADPAGARQIS ELQYCYVNGR MMRDKLINHA IRQAYQEKIS GEHQPAYVLY LHIDPHQVDV
     NVHPAKHEVR FHQSRLVHDF IYQGVICALQ ESGAESLPLA AESETQPRWQ PENRPAAGGN
     HFSSPPATPV TVRPPTQLSS RHLAPPAEHH AGQPAGAAAR ETSGGGTAHA GGGPSGWPQQ
     QPGYQKREGA LYQQLLQTPA PRTEDAAPVT SPAAGPAPLP AHSQSLGRLL TVLHDCYAVV
     ERQGGLALVA LPVAARWLRQ AQLEPGTEGL KPQPLLIPVR LKLAAPERQA MQQRTELLQQ
     FGIDLQSDGQ HVTLRAVPLP LRQQNLQNLI PELLGYLARQ QVISSGQLAQ WLARQAEAEL
     TPWNHSRAIA LLAEVERLCP ALLKSPPPGL LQPIDTETAL SALKHE
//
DBGET integrated database retrieval system