ID A0A1W6E680_9BACT Unreviewed; 867 AA.
AC A0A1W6E680;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Zinc-dependent metalloprotease {ECO:0000313|EMBL:ARK10930.1};
GN ORFNames=A6C57_11660 {ECO:0000313|EMBL:ARK10930.1};
OS Fibrella sp. ES10-3-2-2.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC Fibrella.
OX NCBI_TaxID=1834519 {ECO:0000313|EMBL:ARK10930.1, ECO:0000313|Proteomes:UP000193660};
RN [1] {ECO:0000313|Proteomes:UP000193660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ES10-3-2-2 {ECO:0000313|Proteomes:UP000193660};
RA Kim M.K., Srinivasan S., Kim E.B., Kim K.S.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP015317; ARK10930.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W6E680; -.
DR STRING; 1834519.A6C57_11660; -.
DR KEGG; fib:A6C57_11660; -.
DR OrthoDB; 9776599at2; -.
DR Proteomes; UP000193660; Chromosome.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04276; ZnMc_MMP_like_2; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR InterPro; IPR033413; DUF5117.
DR InterPro; IPR033428; DUF5118.
DR InterPro; IPR032534; EcxA_zinc-bd.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR034032; Zn_MMP-like_bac.
DR PANTHER; PTHR38478; PEPTIDASE M1A AND M12B; 1.
DR PANTHER; PTHR38478:SF1; ZINC DEPENDENT METALLOPROTEASE DOMAIN LIPOPROTEIN; 1.
DR Pfam; PF16313; DUF4953; 1.
DR Pfam; PF17148; DUF5117; 1.
DR Pfam; PF17162; DUF5118; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:ARK10930.1};
KW Metalloprotease {ECO:0000313|EMBL:ARK10930.1};
KW Protease {ECO:0000313|EMBL:ARK10930.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000193660};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..867
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012800304"
FT DOMAIN 56..104
FT /note="DUF5118"
FT /evidence="ECO:0000259|Pfam:PF17162"
FT DOMAIN 112..318
FT /note="DUF5117"
FT /evidence="ECO:0000259|Pfam:PF17148"
FT DOMAIN 452..764
FT /note="EcxA zinc-binding"
FT /evidence="ECO:0000259|Pfam:PF16313"
FT REGION 26..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 96832 MW; 0F36E0FD634F13C5 CRC64;
MNLKVTQALY ATGLALCASM TMAQNRPSAP TSATATTPVA NTASPTAAGP PRAAIRPYRE
VITRAAKTSR GLFTAHQVDD KYYLEIADSL LGREFMAITR IAKAPTGAGY GGELANRQVL
RWERGPDRRL LLRVVSYINV ATATGDTLPI SQAVRNSNVE PIAAAFDLRA VRRDTSSVID
VTDFFRNDNQ VVSLTPATKS RYRITTAAAD RSFIQTVKSY PINTEVRVTK TFNVNTTPTP
FSPIPSPQQT VSLPGGNDAG AVTMEINTSM ILLPKEPMRK RLFDSRVGFF ANNYTVYDDN
SQRTEDETFA VRWRLEPKND ADAERQKKGE LIEPKKQIVY YIDPATPTKW RPFLKAGVAD
WQKAFEKAGW KNAIIAKDWN RADTTLSLED ARYSVIRYFA SDIENAYGPN VNDPRSGEII
ESHIGWYHNV MNLLRKWYVV QGAAVDARAR KPKFDDELMG QLIRFVSSHE VGHTLGLRHN
FGSSHATPVE KLRDKAFIAQ NGHTASIMDY ARFNYVAQPE DGITDLFPRI GTYDIWAVEW
GYKPVYDTKD AAADKLVLNG WVKSHEKDPR YWFGTEINPM DPRSQSEDLG DNAMKASEYG
IKNLKRIMPN LPEWTKEEAE DYDKLREMYG EVVGQFRRYM GHVTKYVGGI YETPRTYDQT
GMMVYEPTPR ALQKEAMNFL NTQLFQTPTW ILDPKIMPLV RADQGIDYIR TLQETTLNSL
TDVGRLSRLI ETGSGSLAKA GTPSYTLIEF MGDLQNGIYS ELATGKSIDI YRRNLQKAYV
EKLIAVLNTP ASSGATVVAG GGAGFRFNAG PVTDIRKSDI MSVVRGQLTG LQRSIAAAMP
RQADTMSKYH LADIQARIQS ALDPKKG
//
