ID A0A1W6K060_9CREN Unreviewed; 336 AA.
AC A0A1W6K060;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=3-isopropylmalate dehydrogenase {ECO:0000313|EMBL:ARM75923.1};
GN ORFNames=B6F84_07710 {ECO:0000313|EMBL:ARM75923.1};
OS Acidianus manzaensis.
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Acidianus.
OX NCBI_TaxID=282676 {ECO:0000313|EMBL:ARM75923.1, ECO:0000313|Proteomes:UP000193404};
RN [1] {ECO:0000313|EMBL:ARM75923.1, ECO:0000313|Proteomes:UP000193404}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YN-25 {ECO:0000313|EMBL:ARM75923.1,
RC ECO:0000313|Proteomes:UP000193404};
RA Ma Y., Yang Y., Xia J.;
RT "Sulfur activation and transportation mechanism of thermophilic Archaea
RT Acidianus manzaensis YN-25.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; CP020477; ARM75923.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W6K060; -.
DR STRING; 282676.B6F84_07710; -.
DR KEGG; aman:B6F84_07710; -.
DR OrthoDB; 6813at2157; -.
DR Proteomes; UP000193404; Chromosome.
DR GO; GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0009098; P:leucine biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR InterPro; IPR011828; LEU3_arc.
DR NCBIfam; TIGR02088; LEU3_arch; 1.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 3..331
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 336 AA; 37175 MW; 598B67A84A8C674B CRC64;
MYRIALIPGD GVGPELTYKS KKIISKLVEI YKLDIQINEV EAGDIAVSKY GDPLPKDTLK
TIDKSDIILK GPVGESAMDV VVRLRQMYDM YANIRPAKSL PNVPNKYGNV DILIVRENTE
DLYKGYEYYV SEDSTVGMKI ITKKASERIA KVGLKYAKQR KNKVTCVHKA NVMRITDGLF
AKTCREILKN NVEYNEMYVD AAAANLVRNP LMFDVIVTTN VYGDILSDEA AQIAGSLGLA
PSANIGDNKA LFEPVHGAAF DIAGKDIVNP TAFLLSVSMM FDHLYSLSND KKYKDASKSL
SDAIYRVYEE GKTLTPDIGG SSKLSEIIDN IYGKIQ
//
