ID A0A1W6L8R2_9BURK Unreviewed; 804 AA.
AC A0A1W6L8R2;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|SMART:SM00849};
GN ORFNames=A4W93_12260 {ECO:0000313|EMBL:ARN20604.1};
OS Piscinibacter gummiphilus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Piscinibacter.
OX NCBI_TaxID=946333 {ECO:0000313|EMBL:ARN20604.1, ECO:0000313|Proteomes:UP000193427};
RN [1] {ECO:0000313|EMBL:ARN20604.1, ECO:0000313|Proteomes:UP000193427}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NS21 {ECO:0000313|EMBL:ARN20604.1,
RC ECO:0000313|Proteomes:UP000193427};
RA Tabata M., Kasai D., Fukuda M.;
RT "Complete genome sequence of natural rubber-degrading, novel Gram-negative
RT bacterium, Rhizobacter gummiphilus strain NS21.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP015118; ARN20604.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W6L8R2; -.
DR STRING; 946333.A4W93_12260; -.
DR KEGG; rgu:A4W93_12260; -.
DR Proteomes; UP000193427; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000193427};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 61..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 554..747
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 804 AA; 85311 MW; 53122670284B9C51 CRC64;
MVWTRLSFSW RFAALGLAWL GGAFAHLQLA VLPDQGTLAT LLGASLAGGA VAARWPHARV
LLVPVAAVLS FALASAHASW RLADALAASL EREDLVVDGV VASLPQVSEQ GVRFRFEVES
ARFGNEAVRV PAVVQLGWFS GWGGAPQDAH GRPARAAPAD PLPEVRAGDR WRFAVRLRRP
HGLRNPHGFD HELFLFEQGV RAVGTVRPGA VRLGVSWRHP VERLRQHVRD DLIATVADRR
AAGVLAALAV GDQSAIASDD WRIFRDTGIS HLVSVSGVHV TMFAWLAGLL LNAAWARAGP
ASLWVPAPMA ARVGGVLAAA AYALFAGWGV PAQRTVLMLA TVTVLQMGGR RWPLGLTLLV
AAVVVCAADP WALNQSGFWL SFAAVALLLA ASPEGGVRQG APLRRAWLVL HDGARTQAVA
TVGLAPLTLV LFQQVSIVGF AANLVAIPAV TLVVTPLALG GVVLAPLWWL GAWVIQQSNG
LLLWLARMPG AVWTAAAAPP WAQVAGVFGA VLAVMPLPWR LRLLAVPLLV PLAAPAVPRP
AEGRYEVLAA DVGQGSAVLV RTRTRLLLYD TGPAYGGEAN AGERVLAPLL RARGEDRIDR
LVLSHRDTDH VGGAGPLLDR WPVGELLGSL EPGHRLLGLA SSDRRCDAGQ SWTWDGVRFD
VLHPPASDHA RPLKPNAKSC VVRISGPQGS VLLAGDIERA QEAGLVATGV PLASDVLLVP
HHGSRTSSTA AFLDAVRPSV AVIQSGHLNR FGHPVAEVLD RLRARGARVV ESPSCGAWHW
DGDGPPTTAR CTRPGTRRYW HHPG
//
