ID A0A1W6LMM8_9BACT Unreviewed; 991 AA.
AC A0A1W6LMM8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=addA {ECO:0000313|EMBL:ARN57050.1};
GN ORFNames=STSP1_01445 {ECO:0000313|EMBL:ARN57050.1};
OS Sedimentisphaera salicampi.
OC Bacteria; Planctomycetota; Phycisphaerae; Sedimentisphaerales;
OC Sedimentisphaeraceae; Sedimentisphaera.
OX NCBI_TaxID=1941349 {ECO:0000313|EMBL:ARN57050.1, ECO:0000313|Proteomes:UP000193334};
RN [1] {ECO:0000313|Proteomes:UP000193334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST-PulAB-D4 {ECO:0000313|Proteomes:UP000193334};
RA Spring S., Bunk B., Sproer C.;
RT "Comparative genomics and description of representatives of a novel lineage
RT of planctomycetes thriving in anoxic sediments.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP021023; ARN57050.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W6LMM8; -.
DR STRING; 1941349.STSP1_01445; -.
DR KEGG; pbp:STSP1_01445; -.
DR Proteomes; UP000193334; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000193334}.
FT DOMAIN 2..333
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 334..642
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 808..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 23..30
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 991 AA; 110887 MW; A29A29274BE68BD0 CRC64;
MSANWTNQQK DIISSQGTVY VTASAGTGKT AVVIERVLEF ICSGGCLDEL LLITFTNAAA
GEMKERLLGK LRQRGANSSE DIRKHILAQL QLIDAAQIST IHSFCSKIVS NYFFKAGVCA
SYRISHGSEI KVLQKEALQE TMNEVWENPD LARPAAELLE NRDANISSDH SILAEVIKIS
DYCSSLPAPE EWVSNCSSPE DPTNELAKKT NISRFAFGEM LKIYRRKFAE KKRAMNVLDY
SDLEHFALKI LSDEESARQI KTQYRQIYVD EFQDTSGIQN RIIDLLANDN IFLVGDIKQS
IYGFRNARPD LFAEKISKNP EAAKSLSNNF RCRPEIISFA NDVFSEIMQP PESLVDYKGE
HMLEAAAEFQ SFSLPGKPCE QFFIATESNA PRKRELNAIL TAQKVREILS EGEIYENQSP
QSRRKIKMSD IAILKKDLKE YSTYVEQFRQ AGIELKVLGR AELKASIEYI DILSMLKFLN
NPTDQVAMAA VMRSPFYQFS EDQMLQAAVS STGGKLNIQA VEQFAEGSGE MAEKFAAFLE
DTKSLREQIH SLEIPELVWK IINHRNYLAF ASSISGASFR RDNLLKLHSL ACDYQDLSSG
QGAASLPGFI EFLDKLTDKD IGAGTPPGGD AVSLMTVHAS KGLEFPVVIL PDLDKGPKSD
NSQVIMSEKL GLAINSDNTT KEKTPLYDKI SQENSLARID EERRILYVAM TRAKEKLVLI
GADKQADKTN SKSFWNWIYP CSEPKFYSES EIKDIAKNLR AQKEKAASSE QLDLKGITDR
CSITDKIVNP ESGPLKISAS QVGHKEFKPS PVFSSAAPEE QTEADPRQKG SAVHLVFERV
IKSGRFEGID YVRNIYQNLA DEGLIEKEML TENDLSSICG FFNTSAGKNS LQNTSMSEWP
FTAYIEAEKL GIQGDQKVIV QGVIDLVIEN ENDFEIIDFK TDKVSEEQLR ERAEVYKGQL
TAYAIAAEKI LDKPASARRL YFVKNGKMLD I
//
