ID A0A1W6WCL8_9FIRM Unreviewed; 460 AA.
AC A0A1W6WCL8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN ORFNames=B6259_03360 {ECO:0000313|EMBL:ARP50000.1};
OS Ruminococcaceae bacterium CPB6.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae.
OX NCBI_TaxID=1572656 {ECO:0000313|EMBL:ARP50000.1, ECO:0000313|Proteomes:UP000195433};
RN [1] {ECO:0000313|EMBL:ARP50000.1, ECO:0000313|Proteomes:UP000195433}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CPB6 {ECO:0000313|EMBL:ARP50000.1,
RC ECO:0000313|Proteomes:UP000195433};
RA Tao Y.;
RT "Complete genome sequence of Ruminococcaceae bacterial strain CPB6.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
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DR EMBL; CP020705; ARP50000.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W6WCL8; -.
DR STRING; 1572656.B6259_03360; -.
DR KEGG; rbp:B6259_03360; -.
DR OrthoDB; 9800864at2; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000195433; Chromosome.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd06113; citrate_synt_like_1_2; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000195433};
KW Transferase {ECO:0000256|PIRNR:PIRNR001369}.
FT ACT_SITE 337
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 396
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 460 AA; 51927 MW; 3A3C17401CE88B5C CRC64;
MVKTNTAGDF FEITPKIREL TQLSVQHDAL DPSLYMKYDV KRGLRDINGE GVLCGLTDIS
EVRAKKIVND KKVPIPGELY YRGISINDLT RGFLTENRFG FEETAYLLLF GELPSAGQLE
EFRGLLNKYR TLPTNFVRDI IMKAPSCDMM NTLARSVLTL YAYDERANDT SVENTLRQCI
EMIALFPQLA VYGYQAYAHN ADSSQPFFIH TPRDNLSTAE NILYMLRIDN KYSELEARIL
DLALVLHAEH GGGNNSTFTT HVVASSGTDS YSVIAAALSS LKGPKHGGAN IKVVQMFSDM
MEKVHDWNDE EEVGCYLRKL LHGEAFDHKG LIYGMGHAVY SISDPRALIF QKFVEKLSEE
KGRQKEYDLY AMVAQLAPKI IGQERKTYKG VSANIDFYSG FVYYMLGLPI ELFTPVFAMA
RIAGWSAHLL EERINGGKII RPAYKSVAQH RPYVPFSQRQ
//
