ID A0A1W6YJQ4_9BORD Unreviewed; 5311 AA.
AC A0A1W6YJQ4;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=CAL12_11055 {ECO:0000313|EMBL:ARP81325.1};
OS Bordetella genomosp. 8.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=1416806 {ECO:0000313|EMBL:ARP81325.1, ECO:0000313|Proteomes:UP000194151};
RN [1] {ECO:0000313|EMBL:ARP81325.1, ECO:0000313|Proteomes:UP000194151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AU19157 {ECO:0000313|EMBL:ARP81325.1,
RC ECO:0000313|Proteomes:UP000194151};
RA Spilker T., LiPuma J.;
RT "Complete and WGS of Bordetella genogroups.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP021108; ARP81325.1; -; Genomic_DNA.
DR STRING; 1416806.CAL12_11055; -.
DR OrthoDB; 8826085at2; -.
DR Proteomes; UP000194151; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd17649; A_NRPS_PvdJ-like; 1.
DR CDD; cd19543; DCL_NRPS; 2.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 1038..1112
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2143..2217
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3819..3893
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4946..5023
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 957..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1020..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1214..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2223..2272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2434..2453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3522..3544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3909..3932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4533..4554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4868..4887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1034
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2234..2250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5311 AA; 572664 MW; 48556CA28C4E44C5 CRC64;
MAYDPRELAQ RIARLDAQPR AELLRRLAEQ GVDIATLPIV PFPSVERYPL SHAQQGLWLT
WRLDPHSPAY NMAGLLSLEG RLDHPALMQA LADLADRHAV LRTVFVEHHD QLAQQVLETL
PDTFLPARDA ASFDVSGLPA QARETQARRI AAELANQPFD LAAAPAWRIG LIRLDEHTHW
LSIVVHHILA DGWSQDVLLN DLAGCYAARV AGQAPALAPL PIQFGDYALW QREWYAASRL
PAQLDYWKSV LDPAPETLRL PLDRPRPRRR DGVAAACRFT LAPETAAGLR RHARDAGASL
YMCMLALLKL TLSRYCGQDD IAVGSPVADR TRAETHGLIG YLTNMTVLRT RVDTRRDFRA
LLAAVRTTVL DAQANQDCPY DLLVSELGVP RDAGINPLFQ VKCTEQASLS AMAHGRLGDL
VLRGVPAATE HAHFDLSLDY TVDGECVECA LIYATDVWDA VTVATFADTL SACAAAVATD
AGRPLSMLAR ADASPVIAGE HALYPDSDVL ALWTRQVASH GERIAVRAED RTISYRDLDA
AAGRLSELLA AAGVAGESRV GLHAGRGCEF VIGLLAILKA GAACVPMDPD LPPERLTHLL
CDSRACVVLS DAGGAQAPDW LGDVPRIDLR ADAHPCEHPG TTVPVHPAQA AYLIYTSGST
GTPKGVVVSR GALNNYVQGV LARLALPDDA DSMAMVSTVA ADLGHTVLFG ALCAGRTLHM
ISAARAFDPD GFAAYMAEHR IGVLKIVPGH LQALLQSARG ADVLPRHALV LGGEATGWPL
YDRIAGLAPD CRVFNHYGPT ETTVGVLTLA VAPDAPRQGD TVPVGRPLPN MSACVLDDNL
DPVPPGAEGE LYISGPAVAR GYQGRPGQTA ERFLACPHDP AQRMYRTGDR VRVLRDGNLA
FLGRADDQVK VRGYRVEPAE VATALRAIEG VGDAAVVPRA EADGRVQLHA YVTPAGRAAP
AVDGDPHVEG RTDVEGRTDV GGGPDPSVLR ASVAALLPDY MVPATFTVIA ALPRTANGKL
DRRALPEPRR ADATPDDAPV GSVEETLAEI WAEVLGVPRV GRQDNFFELG GDSILSLKVM
ARARRKNLRI APRLIFDHQT LQALAAAIAE AGPRDTPPAA DDASPAAPSR QQPVMSHAQQ
RQWFLWRMDP TSSAYHVSGA MRLRGTLDLP AVARAFDALA ARHTGLRTRF RPTADGLAVP
EVLEPARVVI RQCDLRHEPP APRDSRDPLE SGDTREARDA RARDVAQAWV AEPFDLETGP
LLRVGLITLD DREHVLLIAM HHIVSDGWSM QILVDEFSSL YRDYAQGQAP RLPDIPGEYA
DYGDYAARQR AWLEQGEGQR QLAYWKDALA GEQPVLHLPV DAPRRADGVY RAGSHGFDLP
PSLARALRRT ARERDATVYV LLLAGFQALL HRYCGETDIR VGVPIANRHR EGTEAIIGFF
VNTQVMRATI TPATTLDQLA ASTRDAARQA QAHQDLPFEH LVDALQPDRA VGQTPLFQVM
FNHQRPDYGA LRELPGLEIA DYPIGGQAAQ FELTCNTAEL PDGRIAVNLV HASELFDPRT
IEQLGRHYVA LLEQMTRDAH VRVARAPLNA DAELQRLARW GGQRGETASP DVAPAGIHRR
FEAAVRRHPH APALACGDDV LDYETLNARA NRLAHRLIAA GVGPEIRVGL AARRSAGMVV
AMLAILKAGG AYVPLDPDYP EERLRYTARD SGMTHLMLQT ELASGMAWLE DALPAGAQVI
SFDRTGVHAR CMDPADDAAI DDPDVVVDDA NLAYVIYTSG STGRPKGAQL CHGQVRRLLS
ATDPWFGFGS GDVWTLFHSY AFDFSVWEIF GALCTGGKLV VVPHDVSRSP DEFLELLRAQ
RVTVLNQTPS AFQQLMQAPG LQGRADGHGL ALRVVIFGGE ALEPRALLPW MSAFGDQSPR
LVNMYGITET TVHVTYRPIT LADADTGSSP IGIGIPDLGL CVLDAEMAPA PIGVPGELYV
SGAGLARGYL NRPGLTAERF VAHPDGNGER LYRTGDMARW THDGQLEYLG RLDQQVKIRG
FRIELGEIEA RLLAQAGVRQ CAVLAQTGTE EGQGGDHARL VAYVTPANLD PAMLRQALER
ELPAYMVPAA IVALDALPVT ANGKLDRKAL PRARFESGQD HEAPLGPVEE ALADTWRKVL
GIGRLGRHDN FFEIGGDSIL SLQIVARLRQ AGWRVTPRQM FERQSIAALA EVAVRLDGQG
RSVAGAPAAG TSAAGTSAAG TSSDGASSDA ASDDASADAA RQEDARAETV PGQEVPLLPI
QASFLEQPLP THNHWNQAVL LRSDAEIDID ALRAALAAVV AHHDALRLRY RREADGRWVQ
RYAQADTAAE IRDVPVWDVP VWDVPARDAA QIEAHCARAQ ASLDITDGPL LRAVRMQVAD
GSWRLLLVVH HLAIDGVSWR ILLEDLRLAY EQATTSTSTS TSPSNTTSTP TLPARTASYG
AWARYLREQA AAHLPDAQYW LNQPAGDFPT PDHAGAAARL CDQRRIQLSL TREQTHSLLR
QAPAAYRTQV NDLLLASLAA ALKQWRSVRA VRIDLEGHGR ESGVEPEAPD VTRTVGWFTS
IYPVVLETDG EPEQLIRRTK EQLRGVPRNG MGHGVLKQWG DPSVRDALAR APQAPILFNY
LGQFDAGVGA GGDWRVAAED VGAGQLDSAP LSHALTINGR VYDGRLTLDL GYSGGQWAES
TMRDLAACWT QALSSVIAHC TGGAQGVTPS DFPLARLTQA ELDALPIPAP VGQWQDIYPV
TPMQAGMLFH AVYEHDAAAG STAATSTAAT STVATTTAAT TTAATSTAAT STAPAAADQP
YINQLRVDVR GLDVARFQAA WDAAVARHDV LRTGFVTRAG APLQWIARQA RLPFEQLTLR
GAASDVATQL DALAAAQRAA GFDLTKPPLM RCLLVRVNDD THHFIWTHHH LLMDGWSISQ
LLGEVLSEYA GRVVTRPAGR YKDYLHWLAT RDAKATEAYW TGQLRQLQAP TLLAETVSAA
RLAPDMQPEQ DRYGSWTLDL DDAATQSLAA CARRERVTLN TLVQAALSLV LSLHTGQDTV
AFGATTSGRP DDLAGAQHVL GLYINTLPVL VPLRATQTVG DWLRELQAGN VAAREHEHTP
LYAIQRWAGL GGQALFDTLL VFENYPVDEA LAQPLPGDVR FSGLATTEQT SYPLTVVVSH
RDHLYLRLGH DRLSFGDAEA EMLGRRLLRT LSLLAADGEA GLGTLALLAD QEGDALRSWM
VGGPLAEALA GWRDRPVHAV IAAQAARTPD AVAVSMAVDE QGSAGGTLTL TYAELERQSN
RLAHRLMSLG VGPERRVAIA AHRHPSLVVS LLAVLKTGAA YVPLDPEYPD DRLAYMVQDS
APALVLTQSW LSDRVRSWTD AVLEVDTLDL SGEPYHTPDV PVHTEQACYV IYTSGSTGKP
KGATNRHIGL GNRLAWMQQA YGLGEDDVVL QKTPFSFDVS VWEFFWPLMT GARLALAGVG
EHRDAERLLA RIVDHGVTTL HFVPSMLHAF VAHCESQVAT VKGSDARQGH DASRGQGTPP
AGDVPVLDAA RQVLRRVFCS GEALPAELCG RFQALFPNTE LHNLYGPTEA AIDVTSWDCA
NASGTGVPIG RPIAGLRTHV LDANLNEVPP GVAGELYLGG TGLGRGYLNR PGLTADRFVA
DPYGTGLRLY RTGDLARWNH EGQLEYLGRL DHQVKLRGQR IELGEIEAQL QAQAGVQQAA
VLAQAGAPPG PGNAGNAGVA STVGTAGTAS TASVRLVAYV TPADLDAAEL RQALERSLPA
YMVPSAFVLL DKLPVTANGK LDRRALPQAE FTVTDPYEPP QGQAEETLAA IWRDVLGIDQ
IGRHDNYFEV GGDSILSIQI VARARQAGLR LTPRQVFEHQ TIAELANDAV PMPVPVPTHG
FDAPVPPAAA APAPGMSTAV SQGMASRNPP VRQTLADHPG TPAAATLGLA DAGIEDVHSL
SPTQEGMLFH SIEANGKALY VNQISVRVHG ADAQRLADAW AAMVARHPTL RTSFLWQAGM
DRPLQIVHRH VDPQVRVLDW RGRPDLPEQL AAHAAAEAQA IDLARPPLSR LALIRLDADT
HQLIWTHHHL LLDGWSASRL MGEWLRAYGG DPLPPAGPAY GRYVRWLAGQ DRQASERFWQ
QALRSLDGPT LLGQCPGARQ QPGAEGYARI YTRLDAARTA SLRQFAQSQR VTLNTVIQAA
WGLLLQRCAG KDTVVFGATV SGRPAALEGV EDILGLFINT IPVPVRAAPS RTVGDFLRDL
QAENLRLREH EHAGLADIQR WAGSSGRPLF DSIIVFENYP VDRTLKGRER YGLRFEDSHG
GGLTGYVMDI QVVATDEIEL EYCYATATLP EAMVLDLRRQ MEQLLREIER DARAPVGNLG
WLDEAALGHL RDWGRDAGQP PAGERGYVHE LIAAHARRQP DALAVVMDDG AYTYAALDAA
ANRLAHRLVR AGIGPEVRVG VAMPRSLDIV VAFLAVLKAG GTYVPMDLDH PEDRLAYIAR
DSGMALLLAA SSAPAHLSRI GVPVLACDAA ITAGQPSGQP STQPPGPPST QPRVRLSPDN
LAYIIYTSGS TGKPKGVAVS HGPLAMHCQA TARIYGMTPD SRELLFMSFS FDGAHERWLT
TLTTGARLAV RGQDLWTAQE SLDALRRYGI TNGAFPPAYL AQMAEHAALH GNAPTMDLYV
FGGEAMPRAV YERVRTHLPA RSYINGYGPT ETVVTPLIWK TPADAGFDCA YAPIGKTVGE
RQLYVLDADL RPVPVGHVGE LYIGGYGVAR GYLGRMALTA ESFVADPFGD PGSRMYRSGD
MVRWLPDGNV EYIGRRDNQV KIRGFRIELG EVESRILALP GVEEAAVVVH QGPSGTQLAA
YIGAGQQSAS TGTPGTPGAT GTTGITTPGA HALAARLRTQ LAAQLPDYMV PASITVLPSL
PRLISGKLDR QSLPAPGAAA QREFVAPSTD AARQLAAIWE NVLDAPRVGQ TDNFFELGGD
SLLSLKMLSR VRALAHPDLT FTLRDLMRQP TIAGLLGLDE IQPPAPVPLN GGQGTRAPLF
CVHAGMGTLY DYQPLARDFD GIQPIYGLPC RMLLDDAHLD HSLSQMADDY CAMVVAAQPQ
GPIHLLGWSL GGTLAAMMTQ RLEAQGRTVA FLGLVDPYVS GLEQDPLRDW REDLPAYARL
MVPDIPRDRT AAIDLAGEPE LTQEAAASRL RDLLDGSTAG QAALGAQELA RIFLVARRLQ
ALSLEAGPVG KVRARPWCWW RADRDPVQRW TLSAQLGHAT GVVHRTLDAD HYAIIRAAGL
REQLAAVLAM ACDNGDAADD DAEAALVAED L
//
